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張惠華 Louis W. Chang

Louis W.Chang

張惠華 客座講座教授(Louis W. Chang)

E-mail:

TEL:06-2353535 ext 4226

FAX:06-2095845

 

Educations / Professional Experience

 

Educations 1987-1988

In-vitro Neuroscience/Biochem. Neurotoxicology(Professors Jean deVellis  and Anthony Verity),U.C.L.A ‑ Brain Research Institute Los Angeles,California

 

1969-1972

Ph.D., Pathology  with Minor in Neuroscience,University of Wisconsin-Madison School of Medicine Madison, Wisconsin

 

1968-1969

Ph.D. Candidate,Anatomy (CompletedQualifying Exam.),Tufts University School of Medicine,Boston, Massachusetts

 

1967‑1969

Neurocytology(Prof. Sanford Palay)、Medical Pathology(Prof. Samuel Farber),Harvard Medical School,Boston, Massachusetts

 

1966-1969

M.S., Anatomy and Histochemistry Tufts University,School of Medicine,Boston, Massachusetts

 

1962-1966

B.A., Chemistry and Biology University of Massachusetts  Amherst, Massachusetts

   

 

Current Appointments

2004 - present

Adjunct Professor, Department of Occupational Health and Safety, Chung-Shan Medical        University, Taichung, Taiwan

 

2000 - present

Emeritus Professor of Pathology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

 

1999 - present

Founding Director and Investigator, Div. of Environmental Health & Occupational Medicine, National Health Research Institutes, Taiwan

 
 
Former Appointments

1972/7-1973

Instructor in Pathology, University of Wisconsin

 

1972/7-1976

Director, Histopathology and Histochemistry Laboratories, University of Wisconsin

 

1973/7-1976/12

Assistant Professor of Pathology, Univ. of Wisconsin

 

1977/1-1978/9

Experimental Neuropathologist, Pathology Services, National Center for Toxicological Research, Jefferson, Arkansas

 

1978/10-1981

Guest Scientist, Pathology Services, National Center for Toxicological Research, Jefferson, Arkansas

 

1977/1-1980

Associate Professor of Pathology, University of Arkansas for Medical Sciences, and National Center for Toxicological Research

 

1980-2000

Professor of Pathology and Graduate Director of Experimental Pathology, University of Arkansas for Medical Sciences

 

1983-2000

Professor of Pharmacology & Toxicology, Univ. of Arkansas for Medical Sciences

 

1988‑1991

Acting Director, Division of Toxicology, Dept. of Pharmacology & Toxicology, University of Arkansas for Medical Sciences

 

1988‑1991

Director, Interdisciplinary Toxicology Program, University of Arkansas for Medical Sciences

 

1997-1999

Coordinator, Pathophysiology Ph.D. Program, Univ. of Arkansas for Medical Sciences

 

1999–2004

Director& Investigator, Div. of Environmental Health & Occupational Medicine (DEHOM), National Health Research Institutes (NHRI), Taiwan

 

1990- 1999

Visiting Professor, The Chinese Academy of Medicine, Beijing, China

 

1990-1999

Visiting Professor, Institute of Occupational & Preventive Medicine, Beijing, China

 

1990-1999

Visiting Professor, Industrial University, Xian, China

 

Expertise /Research Interests

 

Environmental Health & Occupational Medicine

Toxicological Risk Assessment/Regulatory Guideline Development

Neuroscience/Neurotoxicology/Neuropathology

Heavy Metal Toxicology/Persistent Organic Pollutants (POPs) Research

Developmental & Reproductive Toxicology/Endocrine Disrupters Research

Histochemistry/Microanatomy/Ultrastructural Cytology

Cellular and Molecular Biology/Toxicogenomics

   

Honors & Awards

 
  • "Golden Forceps Award," first runner‑up for the best contribution of the year in histologicaltechniques. 

  • AFIP 10th Annual Symposium on Histopathological Techniques.  Silver Springs, Maryland, 1974.

  •  "Golden Forceps Award," recipient for the best contribution of the year in histological techniques. 

  • First National Society of Histotechnology Symposium, Silver Springs, Maryland, 1975.

  • Who’s Who in Wisconsin, 1975

  • American Men and Women in Science, 1976

  • Outstanding Young Men of America, 1979

  • Who’s Who in the South and Southwest, 1982

  • Who’s Who in Frontier of Science and Technology, 1983

  • Personality of the South, 1974

  • Distinguished Leadership and Service Award (The American-Chinese   Toxicology Society), 1987/89

  • Who’s Who in Science and Engineering, 1993

  • Who’s Who Among Asian Americans, 1993

  • Who’s Who in the World, 1994

  • International Man of the Year on Medicine and Education, 1994/95

  • Principles of Neurotoxicology, edited by Dr. Chang was selected as one of the 250 Best Health Science

  • Books of the year, 1994/1995

  • The 20th Century Award of Achievement on Toxicology and Medicine, 1995

  • Who’s Who in American Education, 1995

  • The Most Admired Men and Women of the Year, 1995

  • International Directory of Distinguished Leadership, 1995

  • 2000 Notable American Men, 1995

  • 5000 Personalities of the World for Outstanding Achievement, 1996

  • Who’s Who in Sciences and Engineering, 1996/1997

  • 2000 Outstanding people of the 20th Century, 1997/98

  • Golden Scroll of Excellence in Environmental Health and Toxicology, 1997

  • Who’s Who in Medicine and Healthcare, 1999

  • International Scientist of the Year, 2003

 
Books and Book Chapters (1994-2010)
 
  1. Lin, P., Yang R S.H., Yang, C.S., Lin, C.H., Chang, L,W. Toxicology & Safety Evaluation of Quantum Dots, In: Semiconductor Nanomaterials for Life Sciences, Vol. 6: Quantum Dots. (C. Kumar, editor), Wiley Publisher, (in press), 2010.
  2. Chang, L.W. Preface. In: Toxicology of Metals, pp. 1198, Lewis Publishers, CRC Press, Inc., Boca Raton, FL., 1996.
  3. Chang, L.W. Toxico-neurology and neuropathology induced by metals. In: Toxicology of Metals, (L.W. Chang, ed.), Lewis Publishers, CRC Press, Inc., Boca Raton, FL., pp. 511-536, 1996.
  4. Chang, L.W. An introduction to bioresponses and reactivities of metals. In: Toxicology of Metals, (L.W. Chang, ed.), Lewis Publishers, CRC Press, Boca Raton, FL., pp. 111-112, 1996.
  5. Chang, L.W. An introduction to metal effects on other organ systems. In: Toxicology of Metals, (L.W. Chang, ed.) Lewis Publishers, CRC Press, Boca Raton, Fl., pp. 885-886, 1996.
  6. Chang, L.W., and Dyer, R. (editors). Handbook of Neurotoxicology, Marcel Dekker, Inc., N.Y. (1103 pp.), 1995.
  7. Chang, L.W., and Verity, M.A. Mercury Neurotoxicity: Effects & Mechanisms. In: Handbook of Neurotoxicology (L.W. Chang and R. Dyer, eds.), Marcel Dekker, Inc. N.Y., pp. 31-60, 1995.
  8. Chang, L.W. Neurotoxicology of organotin and organolead compounds. In: Handbook of Neurotoxicology (L.W. Chang and R. Dyer, eds.), Marcel Dekker, Inc., N.Y., pp. 171-212, 1995.
  9. Chang, L.W., and Slikker, W. Jr. (editors). Neurotoxicology: Approaches and Methods. Academic Press, Inc., CA, (pp. 824), 1995.
  10. Chang, L.W. Selected histopathological and histochemical methods for neurotoxicity assessment. In: Neurotoxicology: Approaches and Methods (L.W. Chang and W. Slikker, Jr., eds.), Academic Press, Inc., CA, pp. 5-26, 1995.
  11. Fan, A.M., and Chang, L.W. (editors). Toxicology and Risk Assessment. pp. 859, Marcel Dekker, Inc., N.Y., 1995.
  12. Chang, L.W. (editor). Principles of Neurotoxicology, Marcel Dekker, Inc., N.Y. (824 pp.),1994.
  13. Chowdhury, P., Montague, D.C., Rayford, P., Chang, L.W., and Lyn-Cook,B. Nicotine alters pancreatic gene (Ha-ras) expression and induce point mutation and exocrine pancreatic injury. In: Proc. XVI International Cancer Congress, New Delhi, India. Monduzzi Editoire, Bologna Publisher (Italy), pp.369-373, 1994.
     
 
Invited Lectures, Seminars and Symposia (2007-2009)
 
  1. Chang, L.W., Lee, H.L., Lin, P. Enhancement of NNK metabolism by arsenic as the mechanism for increased cigarette smoke lungcarcinogenicity by arsenic. Soc. Of Toxicology Meeting, Baltimore, MD. March 15-19, 2009.

  2. Chang, L.W., Liao, W.T., Yu, H.S., and Lin, P. Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells. 7th ERS Lung Science Conference, Estoril, Portugal, March 27-29, 2009.

  3. Chang, L.W. and Lin, P. Enhancement of cigarette smoke-induced lung carcinogenesis by arsenic. Lung Research Group, University of California-Davis, April 16-17, 2009.

  4. Chang, L.W., Liao, W.T., Yu, H.S., Lin, P. Interaction of cigarette smoke component NNK and arsenic in enhancement of lung carcinogenic risk. AACR 100th Annual Meeting, Denver, CO. (abstract #1217), April 18-22, 2009.

  5. Chang, L.W. Enhancement of cigarette-induced lung carcinogenesis by arsenic. Institute of Molecular Medicine, National Cheng-Kung University, June 12, 2009

  6. Chang, L.W. Synergistic interaction of arsenic and cigarette smoke components, BaP and NNK, in enhancement of carcinogenesis. China Medical University, Taiwan. March, 2008.

  7. Lin P. and Chang, L.W. Potential of tt-DDE in cooking oil fumes in the induction of lung carcinogenesis. Department of Occupational Medicine, National Taiwan University, Taiwan. May, 2008.

  8. Liao, W.T. and Chang, L.W. Enhancement of arsenic on centrosome abnormality in NNK-treated or p53 compromised human lung bronchiolar epithelial cells. Div. of Environmental Health & Occupational Medicine, National Health Research Institutes. June, 2008.

  9. Chang, L.W., Lee H.L., Wu, J.P., Lin, P. Synergistic enhancement of carcinogenic risk via interaction of arsenic and cigarette smoke components. 14th International Charles Heidelberger Symposium on Cancer Research, Urumqi, Xinjiang, China. September 19-25, 2008.

  10. Chang, LW. Enhancement of NNK and BaP metabolisms by arsenic:interaction of cigarette smoke components and arsenic in carcinogenesis. NHRI P.I. Retreat Conference. Long-Tan, Taiwan, September, 2008.

  11. Chang, L.W. Interrelationship between p53, NNK, and arsenic inenhancement of lung carcinogenic risk. International Arsenic Symposium, Kaohsiung Medical University, December 1, 2008.

  12. Chang, L.W. Arsenic Research Program at the National Health ResearchInstitutes. Div. of Environmental Health & Occupational Medicine, NHRI,December 11-12, 2008.

  13. Lee, H.L. and Chang, L.W. Alteration of NNK metabolism in arsenic / cigarette smoke interaction in the enhancement of lung cancer risk. Academia Sinica, Taiwan. March, 2007.

  14. Chang, L.W. Mercury and cardiovascular disease. In: Heavy Metal Toxicology Symposium. International Academy of Oral Medicine and Toxicology (IAOMT) Annual Meeting, Las Vegas, September, 2007

  15. Chang, L.W. Safety evaluation on the nano-material Quantum Dot 705: a pharmacokinetic and pathological study. Department of Environmental Health & Occupational Safety, National Yang Ming University, Taiwan. October, 2007.

 

 

研究成果 Publications -- Louis W. Chang

  1. Chen, R.J., Chang, L.W., Lin, P. and Wang, Y.-J. Epigenetic Effects and Molecular Mechanisms of Tumorigenesis Induced by Cigarette Smoke: An Overview,, Special Issue on Cigarette Smoke and Cancer, Journal of Oncology, (in press), 2011

  2. Lin, C.-H., Yang, M.-H., Chang, L. W., Yang, C.-S., Chang, H., Chang, W.H., Tsai, M-H., Wang,M.-H,, Lin, C.-J., and Lin, P.* Cd/Se/Te-based quantum dot 705 modulated redox homeostasis with hepatotoxicity in mice. Nanotoxicology, (In press), 2011

  3. Chen, J.K., Shih, M.H., Peir, J.J., Liu, C.H., Chou, F.I., Lai, W.H., Chang, L.W., Lin, P., Liu, P., Wang, M.Y., Yang, M.H., Yang, S.C. Radioactive zinc oxide nanoparticles from neutron activation for in vitro tracing and bio-distribution study. Nanotechology, (in press), 2011

  4. Liao, W.T., Lin, P., Yu, H.S., Chang, L.S., Lee, C.H., Chang, L.W. NNK reduced arsenite-induced apoptosis and promote anchorage-independent growth in BEAS-2B cells. TAAP, (revised), 2011.

  5. Lin, P., Wei, Y.H., Wu, S.B., Yang, S.C., Chang, W.H., Chen, Y.T., Lin, C.H., and Chang, L.W. Mitochondria are the target for Cd/Se/Te-based quantum dot (QD-705) toxicity. Nanotoxicology (submitted), 2011.

  6. R-J Chen, L-W Chang, P Lin, Y-J Wang. Epigenetic Effects and Molecular Mechanisms of
    Tumorigenesis Induced by Cigarette Smoke: An Overview. Journal of Oncology. Volume 2011, Article ID 654931, 14 pages (2011)

  7. Liao, W.T., Lin, P., Yu, H.S., and Chang, L.W. Arsenite promotes centrosome abnormalities under a p53 compromised status induced by NNK. TAAP 243, 55-62, 2010.

  8. Lin, P., Yang, R.S.H., Yang, C.S., Lin, C.H., Chang, L.W. Toxicology and Biosafety Evaluation of Quantum Dots, In: Semiconductor Nanomaterials, Volume 6: Quantum Dots. Wiley Publisher, pp. 429 - pp. 463, 2010.

  9. Yang, R.S.H., Chang, L.W., Yang, C.S., and Lin, P. Pharmacokinetics and physiologically-based pharmacokinetic modeling of nanoparticles. J. Nanosci. Nanotechnol. 10. 1-8, 2010.

  10. Wang, C.K., Chang, L.W., Chang, H., Yang, C.H., Tsai, M.H., Tsai, H.T., and Lin, P. Pulmonary changes induced by tt-DDE, a component of cook oil fume. European Respiratory J. 35. 667-675, 2010.

  11. Young, S.C., Chang, L.W., Lee, H.L., Tsai, L.H., Liu, Y.C., Lin, P. Characterization on DNA damage induced by tt-DDE, a component of cooking-oil fume, in human lung epithelial cells. Environ. Mol. Mutagenesis 51, 315-321, 2010.

  12. Wang, Y.J., Chang, H., Kuo, Y.C., Wang, C.K., Siaoa, S.H., Chang, L.W., and Lin, P. Synergism between TCDD and NNK on lung tumor incidence in mice. J. Hazardous Materials (in press), 2010

  13. Liao, W.-T., Yu, H.-S., Lin, P. and Chang, L. W* (2010). Arsenic promotes centrosome abnormalilties under a p53 compromised status induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Toxicol. Appl. Pharmacol. 243, 55–62.

  14. Wang, C.-K., Chang, L.W., Chang, H., Yang, C.-H., Tsai, M.-H., Tsai, H.-T., and Lin, P.(2010) Pulmonary changes induced by trans, trans-2, 4-decadienal, a component of cooking oil fume. European Respiratory Journal 35: 667-675.

  15. Young, S.-C., Chang, L. W., Lee, H.-L., Tsai, L.-H., Liu, Y.-C. and Lin, P. (2010) DNA damages induced by trans, trans-2,4-decadienal (tt-DDE), a component of cooking oil fume, in human bronchial epithelial cells. Environmental and Molecular Mutagenesis 51: 315-321.

  16. Liao, W.T., Lin, P., Yu, H.S., and Chang, L.W. Enhancement of centrosome abnormality by NNK and arsenic in human bronchiolar epithelial cells. (in preparation), 2009.

  17. Lin, P., Wei, Y.H., Wu, S.B., Yang, S.C., Chang, W.H., Chen, Y.T., Lin, C.H., and Chang, L.W.Mitochondria are the target for Cd/Se/Te-based quantum dot (QD-705) toxicity. Nature Nanotechnology,(submitted), 2009.

  18. Liao, W.T., Yu, C.L., Lan, C.C., Lee, C.H., Chang, C.S., Chang, L.W., You, H.L., Yu, H.S.Differential effects of arsenic on cutane4ous and systemic immunity: focusing on CD4+ cell apoptosis in patients with arsenic-induced Bowen’s disease. Carcinogenesis, submitted, 2009.

  19. Wu, J.P., Chang, L.W., Yao, H.T., Chang, H., Tsai, H.T., Tsai, M.H., Yeh, T.K., and Lin, P.Oxidative stress and activation of AhR are the basis of CYP1A1 induction and increased BaP metabolism by arsenic. Toxicol. Sci. 107, 385-393, 2009.

  20. Chang, L.W., Lin, P. Arsenic lung carcinogenesis. Genomic Medicine Research Center, UC-Davis, April 15, 2009.

  21. Chang, L.W., Lin, P. Interaction of cigarette smoke component NNK and arsenic in enhancement of lung carcinogenic risk. AACR 100th Annual Meeting, Abstract #1217, Denver, CO, April, 2009.

  22. Wu, J.-P., Chang, L. W., Yao, H.-T., Chang, H., Tsai, H.-T., Tsai, M.-H., Yeh, T.-K. and Lin, P.(2009) Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study. Toxicol. Sciences 107(2), 385–393.

  23. Lin, C.-H., Chang, L. W., Chang, H., Yang, M.-H., Yang, C.-S., Lai, W.-H., Chang, W.-H., and Lin, P.* (2009) Chemical fate of Cd/Se/Te-based quantum dot 705 in the biological system: toxicity implications. Nanotechnology 20, 115-201.

  24. Yao, H.-T., Lin, P., Chang L.-W., Chen, C.T., Chiang, M.-T., Chang, L., Kuo, Y.-C., Tsai, H.-T., and Yeh, T.-K.(2009) Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes. Food and Chemical Toxicology 47, 1703–1709.

  25. Wu, J.P., Chang, L.W., Yao, H.T., Chang, H., Tsai, H.T., Tsai, M.H., Yeh, T.K., and Lin, P. Oxidative stress and activation of AhR are the basis of CYP1A1 induction and increased BaP metabolism by arsenic. Toxicol. Sci. 107, 385-393, 2009.

  26. Lin, C.H., Chang, L.W., Chang, H. Yang, M.H., Yang, C.S., Lai, W.H. Chang and Lin, P. Chemical fate of Cd.Se/Te-based quantum dot 705 in the biological system: toxicity implications. Nanotoxicology 20, 101 -115, 2009.

  27. Liao, W.T., Yu, C.L., Lan, C.C., Lee, C.H., Chang, C.S., Chang, L.W., You, H.L., Yu, H.S. Differential effects of arsenic on cutane4ous and systemic immunity: focusing on CD4+ cell apoptosis in patients with arsenic-induced Bowen’s disease. Carcinogenesis 30, 1064-1072, 2009.

  28. Lee, H.L., Wu, J.P., Chang, L.W., Ueng, T.H., Tsai, M.F., Hsieh, D.P.H., and Lin, P. Enhancement of metabolic activation of NNK in mouse liver by arsenic. Toxicol. Appl. Pharmacology 227, 108-114 2008.

  29. Ho, C.C., Ling, Y.C., Chang, L.W., Tsai, H.T., Tsai, M.H., and Lin P. 17 beta-estradiol and hydroxyestradiols interact via the NF-kappa B pathway to elevate cyclo-oxygenase 2 expression and prostaglandin E2 secretion in human bronchiole epithelial cells. Toxicol. Sci. 104, 294-302, 2008.

  30. Chang, H. and Chang, L.W. Deposition of nano-particles in the biological system. Science Development (National Science Council, Taiwan) 431, 24-27, 2008.

  31. Lin, P., Chang, L.W., Chen, J.W., Wu, J.P., Tsai, M.H., Wang, H.J., Kuo, Y.C., Yeh, T.K., Yang, C.S., and Yang, R.S.H. A physiological based pharmacokinetic model for nanoparticles, Quantum Dot 705, in mice. Environ. Sci. Tech., 42, 6264-6270, 2008.

  32. Lin, P., Yang, M.H., Liao, P.C., Wu, H.Y., Chang, L.W., Tsai, H.T., and Tyan, Y.C. Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells. Biochem. Biophysical Res. Communications, 376,519-524, 2008.

  33. Chao, M.R., Wang, C.J., Wu, M.T., Pan, C.H., Kuo, C.Y., Yang, H.J., Chang, L.W., Hu C.W. Repeated measurements of urinary methylated/oxidative DNA lesions, acute toxicity, and mutagenicity in coke-oven workers. Cancer Epidem. Biomarkers & Prevention 17(12), 3381-3389, 2008.

  34. Lee, H.L., Hsueh, Y.M., Chung, C.J., Pu, Y.S., Chang, L.W., Hsieh, D.P., Liou, S.H. Correlation between the urin profile of 4-(methylnitrosamino)-1 butanone metabolites and 7-methylguanine in urethral carcinoma patients. Cancer Epidem. Biomarkers & Prevention, 17(12), 3390-3395, 2008.

  35. Hong, C.H., Lee, C.H., Chang, L.W., Chiou, M.H., Hsieh, M.C., Kao, Y.H., and Yu, H.S. Anti-endothelial cell IgG from patients with chronic arsenic poisoning induces endothelial proliferation and VEGF-dependent angiogenesis. Microvascular Research 76, 194-201, 2008.

  36. Liao, W.T., Lin, P., Cheng, T.S., Yu, H.S., and Chang, L.W. Arsenic promotes centrosome  abnormalities and cell colony formation in p53 compromised human lung cells. Toxicol. Appl. Pharmacology, 225, 162-170, 2007.

  37. Yang, R.S.H., Chang, L.W., Wu, J.P., Tsai, M.H., Wang, H.J., Kuo, Y.C., Yeh, T.K., Yang, C.S., and Lin, P. Persistent tissue kinetics and redistribution of nanoparticles, Quantum Dot 705, in mice: ICP-MS quantitative assessment. Environmental Health Perspectives 115, 1339-1343, 2007.

  38. Cheng, Y.H., Chang, L.W., Cheng, L.C., Tsai, M.H., Lin, P. 4-Methoxyestradiol induced oxidative injuries in human lung epithelial cells, Toxicol. Appl. Pharmacol. 220, 271-277, 2007.

  39. Chang, L.W., Chang, Y.C., Ho, C.C., Tsai, M.H., and Lin, P. Increase of carcinogenic risk via enhancement of COX-2 expression and hydroxyestradiol accumulation in human lung cells as a result of interaction between BaP and 17-beta estradiol. Carcinogenesis 28, 1606-1612, 2007.

  40. Chen, S.C., Tsai, M.H., Wang, H.J., Yu, H.S., Chang, L.W. Involvement of substance P and neurogenic inflammation in arsenic-induced early vascular dysfunction. Toxicol. Sci. 95(1), 82-88, 2007.

  41. Chao, M.R., Wang, C.J., Yen, C.C., Yang, H.H., Lu, Y.C., Chang, L.W., Hu, C.W. Simultaneous determination of N7-alkylguanines in DNA by isotope-dilution LC-tandem MS coupled with automated solid-phase extraction and its application to a small fish model. Biochemical Journal 402, 483-490, 2007.

  42. Hu, C.W., Wang, C.J., Chang, L.W., and Chao, M.R. Clinical-scale high throughput analysis of urinary 8 oxo-G by isotope-dilution liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction. Clinical Chemistry 52, 1381-1388, 2006.

  43. Cheng, Y., Chang, L.W., Tsou, T.C. Mitogen-activated protein kinases mediated arsenic-induced down-regulation of surviving in human lung adenocarcinoma cells. Arch Toxicol. 80, 310-318, 2006.

  44. Tsou, T.C., Tsai, F.Y., Yeh, S.C. and Chang, L.W. ATM/ATR-related checkpoint signals mediate arsenite-induced G2/M arrest in primary aortic endothelial cells. Arch Toxicol.80(2), 804-810, 2006.

  45. Chang, F.H., Wang, H.J., Wang, S.L., Wang, Y.C., Hsieh, D.P.H., Chang, L.W., Ko, Y.C. Survey of urinary nickel in residents of areas with high density of electroplating factories. Chemosphere 65,1723-1730,2006.

  46. Chang, F.H., Wang, S.L., Huang, Y.L., Tsai, M.H., Yu, S.T., and Chang, L.W. Biomonitoring of chromium for residents living in areas with a high density of electroplating factories. Journal of Exposure Analysis and Environmental Epidemiology 16, 138–146, 2006.

  47. Hu, C.W., Pan, C.H., Huang, Y.L., Wu, M.T., Chang, L.W., Wang, C.J., and Chao, M.R. Effects of arsenic exposure among semiconductor workers: A cautionary note on urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine. Free Radical Biology & Medicine 40, 1273-1278 2006.

  48. Chao, M.R., Wang, C.J., Chang. L.W., and Hu, C.W. Quantitative determination of urinary N7-eyhylguanine in smokers and non-smokers using an isotope dilution liquid chromatography/tandem mass spectrometry with on-line analyte enrichment. Carcinogenesis 27, 146 – 151, 2006.

  49. Chao, M.R., Wang, C.J., Chang. L.W., and Hu, C.W. Quantitative determination of urinary N7-eyhylguanine in smokers and non-smokers using an isotope dilution liquid chromatography/tandem mass spectrometry with on-line analyte enrichment. Carcinogenesis 27, 146 – 151, 2006.

  50. Cheng, Y., Chang, L.W., and Tsou, T.C.  Mitogen-activated protein kinases mediate arsenic-induced down-regulation of survival in human lung adenocarcinoma cells.  Arch Toxicol. 19, 1-9, 2005.

  51. Chen, S.C., Tsai, M.H., Wang, H.J., Yu, H.S., and Chang, L.W. A mouse model for the study of vascular permeability changes induced by arsenic. Toxicology Mechanism & Methods 15, 433 – 437, 2005

  52. Chang, L.W., Lo, W.S., and Lin, P.  Trans, trans-2,4-decadienal, a product found in cooking oil fumes, induces cell proliferation and cytokine production due to reactive oxygen species in human bronchial epithelial cells. Toxicol. Sci. 87, 337-343, 2005.

  53. Tsou, T.C., Yeh, S.C., Tsai, E.M., Tsai, F.Y., Chao, H.R., and Chang LW. Arsenite enhances tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1.  Toxicol. &  Appl Pharmacol. 209,10-8, 2005.

  54. Tsou, T.C., Tsai, F.Y., Hsieh, Y.W., Li, L.A., Yeh, S.C., and Chang, L.W. Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthesis. Toxicol. &  Appl Pharmacol. 208, 277-84, 2005.

  55. Ueng, T.H., Hung, C.C., Kuo, M.L., Chan, P.K., Hu, S.H., Yang, P.C. and Chang, L.W. Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells. Toxicol Sci. 87, 483-496, 2005.

  56. Chang, H., Wang, Y.J., Chang, L.W., and Lin, P.  A histochemical and pathological study on the interrelationship between TCDD-induced AhR expression, AhR activation, and hepatotoxicity in mice. J Toxicol Environ Health 68, 1567-1579, 2005.

  57. Chao, M.R., Wang, C.J., Yang, H.H., Chang, L.W., and Hu, C.W. Rapid and sensitive quantification of urinary N7-methylguanine by isotope-dilution liquid chromatography/electron spray ionization tandem mass spectrometry with on-line solid-phase extraction.  Rapid Commun Mass Spectrom.  19, 2427-2432, 2005.

  58. Wang, S.L., Lin, C.Y., Guo, Y.L., Lin, L.Y., Chou, W.L., Chang, L.W. Infant exposure to polychlorinated dibenzo-p-dioxins, dibenzsofurans and biphenyls (PCDD/Fs, PCBs: correlation between prenatal and postnatal exposure. Chemosphere, 54, 1459-1473, 2004.

  59. Chen, S.C., Tsai, M.H., Wang, H.J., Yu, H.S., and Chang, L.W. Vascular permeability alterations induced by arsenic. Human & Expt’l. Toxicology 23(1), 1-7, 2004.

  60. Chao, M.R., Hu, C.W., Chen, Y.L., Chang-Chien, G.P., Lee, W.J., and Chang, L.W. Approaching gas-particle partitioning equilibrium of atmospheric PCDD/Fs with increasing distance from an incinerator:   measurements and observations on modeling. Atmospheric Environ.  38,1501-1510, 2004.

  61. Li, L.A., Wang, P.W., and Chang, L.W. PCB126 stimulates basal and inducible aldosterone biosynthesis of human adrenocortical H295R cells. Toxicol. Appl. Pharmacol. 195, 92-102, 2004.

  62. Tsou, T.C., Yeh, S.C., Tsai, F.Y., and Chang, L.W. The protective role of intracellular GSH status in the arsenite-induced vascular endothelial dysfunction. Chem. Res. Toxiocol. 17, 208-217, 2004

  63. Lin, P., Chang, Y.C., Chen, C.H., Yang, W.J., Cheng, Y.H., and Chang, L.W. A comparative study on the effects of 2,3,7,8- tetracholordibenzo-p-dioxin (TCDD), polychlorinated biphenyl 126, and estrogen in human bronchial epithelial cells. Toxicol. & Appl. Pharmacol. 195(1), 83-91, 2004.

  64. Liao, W.T., Chiang, K.L., Yu, C.L., Chen, G.S., Chang, L.W., and Yu, H.S. Arsenic induces human keratinocyte apoptosis by the FAS/FAS ligand pathway which correlates with alterations in nuclear factor-kB and activator protein-1 activity. J. Investigative Dermatol. 122(1), 125-130, 2004.

  65. Kao, Y.H., Yu CL, Chang, L.W., and Yu, H.S. Low concentrations of arsenic induce vascular endothelial growth factor and nitric oxide release and stimulate angiogenesis in vitro. Chem Res Toxicol. 16(4),460-468, 2003.

  66. Hu, C.W., Chao, M.R., Wu, K.Y., Chang-Chien, G.P., Lee W.J., Chang, L.W., and Lee, W.S. Characterization of multiple airborne particulate metals in the surroundings of a municipal waste incinerator in Taiwan. Atmospheric Environment 37(1),2845-2852, 2003.

  67. Chang, K.L., Liao, W.T., Yu, C.L., Lan, C.C.E., Chang, L.W., and Yu, S.H. Effects of gallium on immune stimulation and apoptosis induction in human peripheral blood mononuclear cells. Toxicol. & Appl.Pharmacol. 193(2), 209–217, 2003.

  68. Kao, Y.H., Yu, C.Y., Chang, L.W., and Yu, H.S. Low concentrations of arsenic induce vascularendothelial growth factor and nitric oxide release and stimulate angiogenesis in vitro. Chem Res.Toxicol.16, 460-468, 2003

  69. Tsou, T.C., Tsai, F.Y., Wu, M.C. and Chang, L.W. The protective role of NF-kB and AP-1 in arsenite-induced apoptosis in aortic endothelial cells. Toxicol. & Appl. Pharmacology 191(2), 177-187, 2003.

  70. Chao, M.R., Wu, K.Y., Hu, C.W., Ma, H.W., Lee, W.S., Chang, G.P., Lee, W.J., and Chang, L.W. Size distribution of particle-bound PCDD/Fs In ambient air of a municipal incinerator. Atmospheric Environment 37, 4945-4954, 2003

  71. Wang, S.L., Lin, C.Y., Guo, Y.L., Chou, W.L., Chang, L.W. Infant exposure to PCDD/Fs, PCBs-correlation between parental and postnatal exposure. Chemosphere 54, 1459-1473, 2003.

  72. Chang, Y.C., Li, C.M., Li, L.A., Jong, S.B., Liao, P.C., and Chang, L.W. Quantitative measurement of male steroid hormones using automated on-line solid phase extraction-liquid chromatography/tandem mass spectrometry and comparison with radioimmunoassay. The Analyst 128, 363-368, 2003.

  73. Hu, C.W., Chao, M.R., Wu, K.Y., Chang-Chien, G.P., Lee, W.J., and Chang, L.W. Characterization of multiple airborne particulate metals in the surroundings of a municipal waste incinerator in Taiwan.  Atmospheric Environment 30 (20), 2845-2852, 2003.

  74. Wang, S.L., Chen, T.T., Hsu, J.F., Hsu, C.C., Chang, L.W., Ryan, J.J., Guo, Y.L., and Lambert, G.H.Neonatal and childhood teeth in relation to perinatal exposure to PCBs/PCDFs: observations from Yuchang children in Taiwan. Environmental Research 93, 131-137, 2003.

  75. Chao, H.R., Wang, S.L., Lin, L.Y., Yu, H.Y., Lu, Y.K., Chou, W.L., Guo, Y.L., and Chang, L.W. PCBs in Taiwanese primipara human milk and associated factors. Bull.of Environ. Contamination and Toxicology 70, 1097-1103, 2003.

  76. Wang, S.L., Chiou, J.M., Chen, C.J., Tseng, C.H., Chou, W.L., Wang, C.C., Wu, T.N., and Chang, L.W. Prevalence of non-insulin dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and non-endemic areas in Taiwan. Environmental Health Perspectives 111, 155-159,2003.

  77. Yeh, J,Y., Cheng, L.C., Ou, B.R., Whanger, P.D., and Chang, L.W. Differential influences of various arsenic compounds on glutathione redox status and antioxidative enzymes in porcine endothelia cells. Cell and Molecular Life Sciences 59, 1972-1982, 2002.

  78. Wu, M.T., Simpson, C.D., Christiani, D.C., Chang, L.W., and Hecht, S.S. Relationship of exposure to coke-oven emissions and urinary metabolites of benzo(a)pyrene in coke-oven workers. Am. J. Ind.Med.,33, 18-25, 2001.

  79. Chiang, S.Y., Huang, T.H., Tseng, Y.S., Kuo, H.W., Wu, K.Y., and Chang, L.W. The formation of N-(2-hydroxyethyl)-valine in Taiwanese smokers and non-smokers. Mutation Research 21, 78-82, 2001.

  80. Sorenson, J.R.J., Soderberg, L.S.F., Chang, L.W., and Walker, R.B. Essential metalloelement chelates facilitate repair of radiation Injury. Metal Based Drugs 8 (4), 215-234, 2001

  81. Chang, L.W., Furst, A., and Fan, A.M.   Metal Toxicology,In: Encyclopedia of Environmental Analysis and Remediation, (R.A.Meyers, ed.)  pp 2750-2761, John Wiley & Sons, Inc., N.Y., 1998.


           N.B.

     

           Between 1995-1998, I have focused large part of my efforts in the organization and production of a series of major textbooks (6) in Neurotoxicology,Toxicology, and Risk Assessment (see Section on “Books & Book Chapters”). These textbooks have become important and major reference sources for toxicologists world wide.

            

           Since 1999, I have made a major change in my career

           and become the Founding Director of the Division of Environmental

            Health and Occupational Medicine (DEHOM) at the National Healt

    Research Institutes (NHRI), a major governmental research

    organization in Taiwan. Since then, I have devoted most of my time

    and effort, as a scientist-administrator, in the development and

    management of the Division. My change of “focus”and career

    development at these time periods required a sacrifice on my own

    research activities and publication productivity. Thus an apparent

    “drop” in publications can be noted between 2000 – 2004. However,

    I am happy that, in lieu of “personal research publications”, I

    have the opportunity to contribute to the scientific world in a different

    way: in producing a series of important texts to the field of

    toxicology(esp. neurotoxicology) and in helping the Taiwan government

    to establish a research institute on Environmental Health &

    Occupational Medicine, which is very much needed in Taiwan.

     

           Since 2004, I have retired from the Directorship and administrative

    duties in DEHOM  and “re-activated” my research. New scientific

    activities and productivity have resumed again in my laboratory.

    These changes are representatively reflected in the amount of research

    publications and manuscripts generated as listed below.  

  82. Chowdhury, P., Rayford, P.L. and Chang, L.W.  Pathophysiological effects of nicotine in pancreas.  Proc. For Soc. Experimental Biology and Medicine, 168-172, 1998.

  83. Chang, L.W., Hsia, S.M.T., Chan, P.C. and Hsieh, L.L.  Addotti Macromolecolari, Enciclopedia Medica Italiana, Aggio. II, Tomo 1, 51-64, 1998.

  84. Chang, L.W. and Guo, G.L.  Fetal Minamata disease.  In: Handbook of Developmental Neurotoxicology, (W.Slikker and L.W. Chang, eds.) Chapter 29, pp 507-516, Academic Press, San Diego, CA, 1998.

  85. Chang, L.W. Cellular and molecular morphogenesis of the nervous system: an introductory overview. In: Handbook of Developmental Neurotoxicology, (W. Slikker and L.W. Chang, eds.) pp. 1-2, Academic Press, Inc., CA. 1998

  86. Chang, L.W. and Guo, G.L.  Neurotoxicology of metals. In: Comprehensive Toxicology, Vol. 11 (H. Lowndes and K. Reuhl, eds,), Chapter 29, pp 495-506, Elsevier Science, Publ., Amsterdam, 1997.

  87. Chang, L.W.  Mercury-related neurological disorders.  In: Mineral and Metal Neurotoxicology (M. Yasui, K. Ota, M. Strong, and M.A. Verity, eds.), CRC Press, Inc., Boca Raton, FL., Chap. 17, pp 169-176, 1996.

  88. Chang, L.W., Hsia, S., Chan, P.C., and Hsieh, L.L.  Macro-molecular adducts as biomarkers.  Italian Medical Encyclopedia, 1996.

  89. Soderberg, L.S.F., Chang, L.W. and Barnett, J.B.  Elevated TNF-a and inducible nitric oxide production by alveolar macrophages after exposure to a nitrite inhalant.  J. Leukocyte Biol. 60,459-464, 1996.

  90. Soderberg, Lee, S.F., Sorenson, J.R., and Chang, L.W.  Modulation of immune system by organometallic complexes.  In: Toxicology of Metals, (L.W. Chang, ed.), Lewis Publishers, CRC Press, Inc., FL., pp 871-884, 1996.

  91. Chang, L.W.  An introduction to metal effects on other organ systems.  In: Toxicology of Metals,(L.W. Chang, ed), Lewis Publishers, CRC Press, Boca Raton, FL., pp 885-886, 1996.

  92. Chang, L.W.  An introduction to bioresponses and reactivities of metals.  In: Toxicology of Metals, (L.W. Chang, ed.), Lewis Publishers, CRC Press, Boca Raton, FL., pp 111-112, 1996.

  93. Chang, L.W.  Toxico-neurology and neuropathology induced by metals. In: Toxicology of Metals.  (L.W. Chang, ed.), Lewis Publishers, CRC    Press, Inc., Boca Raton, FL., pp 511-536, 1996.

  94. Chang, L.W.  An introduction to neuropathology of metals.  In: Toxicology  of Metals, (L.W.Chang, ed.), Lewis Publishers, CRC Press, Inc., Boca Raton, FL., pp 509-511, 1996.

  95. Chang, L.W.  Preface.  In: Toxicology of Metals.  Lewis Publishers, CRC Press, Inc., Boca Raton,FL., 1996.

  96. Fan, A.M. and Chang, L.W.  Preface.  In: Toxicology Risk Assessment (A.M. Fan and L.W. Chang, eds.), Marcel Dekker, Inc., N.Y., 1996.

  97. Chang, L.W.  Selected histopathological and histochemical methods for neurotoxicity assessment.  In: Neurotoxicology: Apaproaches and Methods (L.W. Chang and W. Slikker, Jr., eds.), Academic Press, Inc., CA, pp. 5-26, 1995.

  98. Chang, L.W.  Introductory overviews on neuromorphological and neuropathological approaches.  In: Neurotoxicology: Approaches and Methods (L.W. Chang and W. Slikker, Jr., eds.), Academic Press, Inc., CA, pp. 3-4, 1995.

  99. Chang, L.W.  Preface.  In: Neurotoxicology: Approaches and Methods (L.W. Chang and W. Slikker, eds.), Academic Press, Inc., CA, 1995.

  100. Chang, L.W.  Neurotoxicology of organotin and organolead compounds. In: Handbook of Neurotoxicology (L.W. Chang and R. Dyer, eds.), Marcel Dekker, Inc., N.Y., pp. 171-212, 1995.

  101. Chang, L.W., and Verity, M.A.  Mercury Neurotoxicity: Effects & Mechanisms.  In: Handbook of Neurotoxicology (L.W. Chang and R. Dyer, eds.), Marcel Dekker, Inc., N.Y., pp. 31-60, 1995.

  102. Chang, L.W.  Introductory overview: Metal neurotoxicology.  In:  Handbook of Neurotoxicology, (L.W. Chang and R. Dyer, eds.), Marcel Dekker, Inc., N.Y., pp. 29-30, 1995.

  103. Chang, L.W.  Preface.  In: Handbook of Neurotoxicology (L.W. Chang and R Dyer, eds.), Marcel Dekker, Inc., N.Y., 1995.

  104. Chowdhury, P., Montague, D.C., Rayford, P., Chang, L.W., Lyn-Cook, B., Nicotine alters pancreaticgenes (Ha-ras)expression and induce point mutation and exocrine pancreatic injury. In: Proc. XVI International Cancer Congress, New Delhi, India, Monduzzi Editoire Publisher, pp 369-373, 1994.

  105. Chang, L.W., and Abou-Donia, M.B.:  Introductory overview: Neurotoxicology of the PNS.  In: Principles of Neurotoxicology (L.W. Chang, ed.), Marcel Dekker, Inc., NY, pp. 111-112, 1994.

  106. Chang, L.W.  Preface.  In: Principles of Neurotoxicology, (L.W. Chang, ed.), Marcel Dekker, Inc., N.Y., 1994.

  107. Chowdhury, P., Montague, D., Rayford, P., Chang, L.W., and Lyn-Cook, B. Nicotine alters pancreatic gene expression and induces point mutations and exocrine pancreatic injury.  Proceedings of International Cancer Congress XVI (Eds: R.S. Rao, M.G. Deo, and L.D. Sanghvi), pp. 369-373, 1994.

  108. Hsieh, L.L., Hsia, S.M.T., Chan, P.C., and Chang, L.W.  Macromolecular adducts: biomarkers for toxicity and carcinogenesis. Annual Rev. of Pharmacol. & Toxicol. 34, pp. 41-67, 1994.

  109. Chang, L.W.  Neurotoxicity of Organotins and Organoleads.  In:  Handbook of Clinical Neurology, Part 1.  Intoxications of the Nervous System. (F. de Wolff, ed.), Elsevier Publ., Amsterdam, 1994.

  110. Chang, L.W.  Introductory Overview:  CNS  Neurotoxicity.  In:  Principles of Neurotoxicology.  (L.W. Chang, ed.), Marcel Dekker, Inc., N.Y., pp. 1-2, 1994.

  111. Chang, L.W.  Introduction to Basic Principles of Neurocytology and General Concepts on Neurotoxicopathology.  In: Principles of Neurotoxicology.  (L.W. Chang, ed.), Marcel Dekker, Inc., N.Y., pp. 3-4, 1994.

  112. Chang, L.W., and Cockerham, L.  Metal in the Environment and neurotoxicity.  In: Environ Toxicity (L. Cockerham, ed.).  CRC Press, FL, pp. 109-132, 1994.

  113. Montague, D.C., Lyn-Cook, B., Chowdhury, P., and Chang, L.W., et al., Retrieval and amplification of DNA from unstained histopathological sections. Biom. & Environmental Sciences 6, 221-216, 1993.

  114. Chowdhury, P., Doi, R., Chang, L.W., et al., Tissue distribution of 3H-nicotine in rats. Biomed. & Environmental Sciences 6, 59-64, 1993.

  115. Tangoku, A., Doi, R., Chowdhury, P., Chang, L.W., et al., Exogenous administration of cholecystokinin and estradiol alters exocrine of pancreatic function in rats. Int. J. Pancreatology 13(2), 1-6, 1993

  116. Tangoku, A., Doi, R., Chowdhury, P., Blevins, G.T., Pasley, J.N., Chang, L.W., and Rayford, P.L.  Humoral factors that induce alterations of the pancreas in obstructive jaundice rats.  Pancreas     8:103-108, 1993.

  117. Sorenson, J.R.J., Soderberg, L.S.F., Chang, L.W., Willingham, W.M., Baker, M.L., Barnett, J.B., Salari, H., and Bond, K.  Copper, iron, maganese, and zinc 3,5-Diisopropylsalicylate complexes increase survival of gamma irradiated mice.  Medicinal Chemistry  28:221-229, 1993.

  118. Chang, L.W.  The concept of direct and indirect neurotoxicity and the concept on toxic metal/essential element interactions as a common biomechanism underlying metal toxicity.  In:  The Vunerable Brain:  Vol. I. Malnutrition and Toxins (Eds: R.L. Isaacson, K.Jensen), Plenum Press, N.Y., Chapter 5, pp. 61-82, 1992

  119. Chang, L.W.  Basic histopathologicl alterations in the central and peripheral nervous system:  classification, identification, approaches, and techniques.  In:  Neurotoxicology (edited by M.B. Abou-Donia).  CRC Press, FL, pp. 223-252, 1992.

  120. Chowdhury, P., Rayford, P.L., and Chang, L.W.  Induction of pancreatic acinar via inhalation of nicotine.  Proc. Soc. Exp. Biol. Med. 201:159-164, 1992.

  121. Chang, L.W., Yang, C.M., Deng, J.F., and Chen, C.F.  Toxicity of Bajiaolan (podophyllum).  CAPASUS Proceedings 16:25-39, 1992.

  122. Chang, L.W., Yang, C.M., Chen, C.F., and Deng, J.F.  Experimental podophyllotoxin (Bajiaolian) poisoning: II. Effects on the liver, intestine, kidney, pancreas, and testis.  Biomed. Environ. Sciences 5:293-302, 1992.

  123. Chang, L.W., Yang, C.M., Chen, C.F., and Deng, J.F.  Experimental podophyllotoxin (Bajiaolian) poisoning: I. Effects on the nervous    system.  Biomed. Environ. Sciences 5:283-292. 1992.

  124. Chang, L.W., and Fan, A.M.  Cadmium contamination: environmental aspects, health effects, clinical and land managements.  In:  Proc. Symp. on Health Risk Assessment on Environmental, Occupational, and Life Style Hazards, Institute of Biomedicl Sciences, Academia Sinica, pp. 199-230,Taipei,Taiwan, 1991.

  125. Soderberg, L.S.F., Barnett, J.B., and Chang, L.W.  Inhaled isobutyl nitrite impairs T cell reactivity.   In:  Drugs of Abuse: Immunity and Immunodeficiency (Ed. H. Friedman), Plenum Press, N.Y., pp. 265-268, 1991.

  126. Ali, S.F., Chang, L.W., and Slikker, W.  Biogenic amines as biomarkers for neurotoxicity.  In:  Recent Advances in Biomarker Research (L.W. Chang and R.W. Hart, eds.), Biomed. & Environ,Sciences (special issue), Vol. 4, Academic Press, pp. 207-216, 1991.

  127. hang, L.W. and Hart, R.W. (Editors).  Recent Advances in Biomarker Research, Biomed. & Environ. Sciences, Vol. 4, No. 1-2, Academic Press, N.Y., 1991.

  128. Fan, A.M. and Chang, L.W.  Human exposures and biological monitorings: Methylmercury and Selenium.  In: Biological Monitoring of Exposure to Chemicals-Metals (H.K. Dillon, Ed.), John Wiley Publ., N.Y., Chapter 18, pp. 223-242. 1991.

  129. Chang, L.W.  Neurotoxicity of trimethyltinin the hippocampus:  a hyperexcitatory toxicity.  Korean JToxicol. 6:191-204, 1990.

  130. Chang, L.W.  Organometal toxicity in the nervous system.  In: Proceedings of the Sino-US Bi-National Conference on Toxicology, pp. 107-138, Taipei, Taiwan, 1990.

  131. Sorenson, J.R.J., Soderberg, L.S.F., Baker,M.L., Barnett, J.B., Chang, L.W., Salari, H., and Willingham, W.M.  Radiation recovery agents: Cu(II), MN(II), Zn(II), or FE(III) 3,5-Diisopropyl salicylate complexes facilitate recovery from ionized radiation      induced radical mediated tissuedamage.  In: Antioxidants in     Therapy and Preventive Medicine (Ed. I. Emerit, et al.), PlenumPress, N.Y., 1990.

  132. Chang, L.W.  The neurotoxicology and pathology of organomercury, organotin, and organolead.  J. Toxicol. Sci. 15 (Suppl. IV):125-151, 1990.

  133. Sorenson, J.R.J., Soderberg, L.S.F., Baker, M.L., Barnett, J.B., Chang, L.W., and Willingham, W.M.  Radiation recovery with Cu(II), Fe(III), Zn(II), and Mn(II) 3,5-DIPS complexes and tissue distribution of 67Cu(II)2 [3,5-DIP (Carboxy-14C)S]4Proceedings of Radiation Research Society, pp. 7-12, 1990.

  134. Chowdhury, P., R. Hosotani, L. Chang, and P.L. Rayford.  Metabolic and pathologic effects of nicotine on gastrointestinal tract and pancreas of rats.  Pancreas 5:222-229, 1990.

  135. Chang, L.W. and C.S. Fu.  Neuropathology of heavy metals and its modulation by nutritional influences.  In:  Heavy Metal Toxicology, (ed. E.C. Foulks) pp. 69‑96, CRC Press, 1990.

  136. Chang, L.W. and C.S. Fu. Influences on Heavy Metal Toxicity by Nutritional Elements.  In:  Heavy Metal Toxicity (L.W. Chang, editor Comments on Toxicology Series, Vol. III, No. 3, pp. 239‑249.  Gordon and Breach Science Publ., N. Y. 1989.

  137. Chang, L.W. and A.M. Fan.  Mercury Toxicity:  Pathological aspects and biological monitoring.  IntJBiosocial & Medical Res. 11:57‑73, 1989.

  138. Christ, D., L.W. Chang and D.E. McMillan.  Neurotoxicological effects of trimethyltin on the stellate ganglion.  Neurotoxicol.Teratol. 11:453‑460, 1989.

  139. Chang, L. W., Hough, A. J., Bivens, F., and Cockerill, D.  Effects of adrenalectomy and corticosterone on hippocampal lesion induced by trimethyltin.  Biomedical & Environ. Sci. Res. 2: 54‑64, 1989.

  140. Mattsson, J.L., R.R. Albee, D.L. Eisenbrandt and L.W. Chang.  Subchronic neurotoxicity in rats of the structural funigant, sulfuryl fluoride. Neurotoxicol. Teratol. 10:127‑133., 1988.

  141. Soderberg, L.S.F., Barnett, J.B., Baker, M.L., Chang, L.W., Salari, H., and Sorenson, J.R.J.  Copper (II)2 (3,5‑Diisopropylsalicylate)4 stimulates hemopoiesis in normal and inadiated mice.  Experimental Hematol. 16:577‑580, 1988.

  142. Chang, L.W.  Experimental neuropathology of organic mercurials.  In:  The Toxicity of Methylmercury.  Eds. Z. Annau and C. Eccles. Baltimore:  The Johns Hopkins Univ. Press, pp. 54‑72, 1987.

  143. Frith, C.H., L.W. Chang, D.L. Lattin, R.C. Walls, T. Hamm, and R. Doblin. Toxicity of methylenedionymethamphetamine (MDMA) in dogand rat.  FundApplToxicol. 9:110‑119, 1987.

  144. Torrogrosa, D., S.L. Kasemeier, J.R.J. Sorenson, and L.W. Chang.  Effects of Cu(II) (3,5‑DIPS)2 on solid Ehrlich cell tumor in mice:  a pathological study.  In: Biology of Copper Complexes.  Humana Press, Clifton, NJ, pp. 371‑386, 1987.

  145. Cockerill, D., L.W. Chang, A. Hough, and F. Bivins.  Effects of    trimethyltin on the mouse hippocampus and adrenal cortex. ToxicolEnvironHealth 22:149‑161, 1987.

  146. Chang, L.W.  A proposed pathogenic mechanism on trimethyltin induced lesions in the hippocampus of adult and neonatal rats.  In:  Biol. Trace Element Res., pp. 77‑88, Humana Press, Inc., New York, 1987.

  147. Albee, R.R., J.L. Mattsson, B.L. Yano and L.W. Chang.  Neurobehavioral effects of dietary restriction.  Neurotoxicol. Teratology9:203‑212, 1987.

  148. Chang, L.W.  Central nervous system changes: selective and non‑selective effects.  In: Structural and Functional Effects of Neurotoxicants: Organometals.  Eds. H.A. Tilson and S.B. Sparber pp. 82‑116.  New York: John Wiley & Sons, Publ., 1987.

  149. McMillan, D.E., G.R. Wenger, M.J. Brocco, S.O. Idemudia and L.W. Chang. Effects of Tri‑alkyltins on the schedule‑controlled behavior of the pigeon.  Neurotoxicol. Teratol. 9:67‑74, 1987.

  150. Walsh, T.J., R.L. McLamb, S.C. Bondy, H.A. Tilson and L.W. Chang.  Triethyl and trimethyl lead:  Effects on behavior, central nervous system morphology and concentrations of lead in blood and brain of rat. Neurotox. 7:21‑34, 1986.

  151. Wenger, G.R., D.E. McMillan, and L.W. Chang.  Effects of triethyltin on responding of mice under a multiple schedule of food    presentation.  ToxicolApplPharmacol. 8:659‑665, 1986

  152. McMillan, D.E., L.W. Chang, S.O. Ideumdia and G.R. Wenger.  Effects of trimethyltin and triethyltin on lever pressing, water drinking and running in an activity wheel:  associated neuropathology.  NeurobehavToxicolTeratol. 8:499‑507, 1986.

  153. Baba, M.D., T. Suzuki, T. Tobe, K. Inoue, P. Chowdhury, L.W. Chang and P.L. Rayford.  Influence of obstructive jaundice on the growth of pancreas and basal plasma levels of choletystokinin and gastrin in rats. Digestive Disease & Sci. 31:1233‑1241, 1986.

  154. Chang, L.W.  Neuropathology of trimethyltin: a proposed pathogenetic mechanism.  FundApplToxicol. 6:217‑232, 1986.

  155. Chang, L.W. and Dyer, R.S. Early effects of trimethyltin on the dentate gyrus basket cells: a morphological study.  JToxicolEnvironHlth. 16:641‑653, 1985.

  156. Rastogi, S.K., G.R. Wenger, L.W. Chang and D.E. McMillan.  Effects of triethyltin and its interaction with d‑amphetamine and chlorpromazine on responding under a multiple schedule of food presentation in rats.  NeurobehavToxicolTeratol. 7:239‑242, 1985.

  157. Chang, L.W. and R.S. Dyer.  Septotemporal gradients of trimethyltin‑induced hippocampal lesions.  NeurobehavToxicol.  Teratol. 7:43‑49, 1985.

  158. Chang, L.W.  Neuropathological effects of toxic metal ions.  In: Metal Ions in Neurology and Psychiatry.  Alan R. Liss Series in Neurology and Neurobiology.  Eds. S. Gabay, J. Harris and B.T. Ho.  New York: Alan R. Liss, Inc., Publ. pp. 207‑230, 1985.

  159. Zimmer, L., D. Woolley and L.W. Chang.  Does phenobarbital protect against trimethyltin‑induced neuropathology of limbic structures?  Life Sci. 36:851‑858, 1985

  160. Chang, L.W.  Trimethyltin induced hippocampal lesions at various neonatal ages.  BullEnvironContamToxicol. 33:295‑301, 1984.

  161. Wenger, G.R., D.E. McMillan and L.W. Chang.  Behavioral effects of TMT in two strains of mice.  II. Multiple fixed‑ratio, fixed‑interval. ToxicolApplPharmacol. 73:89‑96, 1984.

  162. Wenger, G.R., D.E. McMillan and L.W. Chang.  Behavioral effects of TMT in two strains of mice.  I. Spontaneous motor activity.  Toxicol. Appl. Pharmacol. 73:78‑88, 1984.

  163. Sorenson, J.R.J., T.M. Rolniak and L.W. Chang.  Preliminary chronic toxicity study of copper aspirinate.  Inorganica ChimicaActa 91:31‑34, 1984.

  164. Chang, L.W. and R.S. Dyer.  Trimethyltin induced zinc depletion in rat hippocampus.  In: Neurobiology of Zinc, Vol. II.  Alan R. Liss Series in Neurology and Neurobiology.  Eds. C. Frederickson and G. Howell.  New York: Alan R. Liss, Inc., Publ., pp. 275‑290, 1984.

  165. Chang, L.W.  Hippocampal lesions induced by TMT in the neonatal rat brain.  Neurotoxicology 5(2):205‑216, 1984.

  166. Chang, L.W. and Z. Annau.  Developmental neuropathology and behavioral teratology of methylmercury.  In: Neurobehavioral Teratology.  Ed. J. Yanai.  Amsterdam: Elsevier Publ., pp. 405‑432, 1984

  167. Chang, L.W.  Developmental toxicology of methylmercury.  In: Toxicology and the Newborn.  Eds. S. Kacew and M.J. Reasor.  Amsterdam: Elsevier Publ. pp. 175‑197, 1984

  168. Chang, L.W., J.H. Menna, P.M. Wang, A.E. Kalderon, J.R.J. Sorenson and D.E. Wennerstrom.  The potential oncogenic activity of influenza type A virus in lungs of mice.  ExpPathol. 25:223‑231, 1984.

  169. Chang, L.W., G.R. Wenger and D.E. McMillan.  Neuropathology of trimethyltin intoxication.  IV. Changes in the spinal cord.EnvironRes. 34:123‑134, 1984.

  170. Gilbert, M.M., J. Sprecher, L.W. Chang and L.F. Meisner.  Protective effect of vitamin E on genotoxicity of methylmercury.  JToxicolEnvironHealth 12:767‑773, 1983.

  171. Chowdhury, P., K. Inoue, L.W. Chang and P.L. Rayford.  Distribution and retention of cadmium by gastrointestinal tract and other organs following intraperitoneal cadmium exposure.  BullEnvironContamToxicol. 31:399‑406, 1983.

  172. Chowdhury, P., L.W. Chang and P.L. Rayford.  Catabolism and tissue distribution of cadmium in rats.  BullEnvironContamToxicol. 31:391‑398, 1983.

  173. Chowdhury, P., L.W. Chang, R.C. Bone and P.L. Rayford.  Potentiation of Cd‑induced pulmonary injury in α‑antitrypsin suppressed rats.  EnvironRes. 30:313‑321, 1983.

  174. Chang, L.W. and R.K. Yip.  Corn oil induced changes in the dorsal root ganglia of rat.  EnvironRes. 30:50‑57, 1983.

  175. Chang, L.W., G.R. Wenger, D.E. McMillan and R.S. Dyer.  Species and strain comparison of acute neurotoxic effects of trimethyltin in mice and rats.  NeurobehavToxicolTeratol. 5:337‑350, 1983.

  176. Reuhl, K.R., E.A. Smallridge, L.W. Chang and B.A. Mackenzie.  Developmental effects of trimethyltin intoxication in the neonatal mouse.  I. Light microscopic studies.  Neurotoxicology 4(1):19‑28, 1983.

  177. Chang, L.W., T.M. Tiemeyer, G.R. Wenger and D.E. McMillan.  Neuropathology of trimethyltin intoxication.  III. Changes in the brain stem neurons.  EnvironRes. 30:399‑411, 1983.

  178. Chang, L.W. and K.R. Reuhl.  Mercury effects on human and animal health.  In: Trace Elements and Health.  Ed. J. Rose. London:    I.P.C. Sci. Technol. Press, Ltd., pp. 132‑149, 1983.

  179. Chang, L.W. and R.S. Dyer.  Trimethyltin induced pathology in sensory neurons.  In: Disease and Chemically Induced Neurological Dysfunction. NeurobehavToxicolTeratol. 5:673‑696, 1983.

  180. Chang, L.W. and R.S. Dyer.  A time‑course study of trimethyltin induced neuropathology in rats.  NeurobehavToxicolTeratol. 5:443‑459, 1983.

  181. Chang, L.W.  Protective effects of selenium against methylmercury neurotoxicity: a morphological and biochemical study.  ExpPathol. 23:143-156, 1983.

  182. Yip, R.K. and L.W. Chang.  Protective effects of vitamin E on methylmercury toxicity in the dorsal root ganglia.  EnvironRes.

  183. Wenger, G.R., D.E. McMillan and L.W. Chang.  Behavioral toxicology of acute trimethyltin exposure in the mouse.  Neurobehav.ToxicolTeratol. 4:157‑161, 1982.

  184. Chowdhury, P., D.B. Louria, L.W. Chang and P.L. Rayford.  Cadmium induced pulmonary injury in mouse: a relationship with serum antitrypsin activity.  BullEnvironContamToxicol. 28:446‑451, 1982.

  185. Chang, L.W., T.M. Tiemeyer, G.R. Wenger, D.E. McMillan and K.R. Reuhl. Neuropathology of trimethyltin intoxication. II. Electron microscopy study of the hippocampus.  EnvironRes. 29:445‑458, 1982.

  186. Chang, L.W., T.M. Tiemeyer, G.R. Wenger, D.E. McMillan and K.R. Reuhl. Neuropathology of trimethyltin intoxication.  I. Light microscopy study. EnvironRes. 29:435‑444, 1982.

  187. Chang, L.W., T.M. Tiemeyer, G.R. Wenger and D.E. McMillan.  Neuropathology of mouse hippocampus in acute trimethyltin intoxication. NeurobehavToxicolTeratol. 4:149‑156, 1982.

  188. Chang, L.W. and R. Suber.  Protective effect of selenium on methylmercury toxicity: a possible mechanism.  BullEnviron.ContamToxicol. 29:285‑289, 1982.

  189. Chang, L.W.  Pathogenetic mechanisms of the neurotoxicity of methylmercury.  In: Mechanisms of Neurotoxic Substances.  Eds. K.N. Prasad and A. Vernadakis.  New York: Raven Press, pp. 51‑66, 1982.

  190. Yip, R.K. and L.W. Chang.  Vulnerability of dorsal root neurons and fibers toward methylmercury toxicity: a morphological evaluation.  EnvironRes. 26:152‑167, 1981.

  191. Reuhl, K.R., L.W. Chang and J.W. Townsend.  Pathological effects of in utero methylmercury exposure on the cerebellum of the golden hamster. II. Residual effects on the adult cerebellum.  EnvironRes. 26:307‑327, 1981.

  192. Reuhl, K.R., L.W. Chang and J.W. Townsend.  Pathological effects of in utero methylmercury exposure on the cerebellum of the golden hamster. I. Early effects upon the neonatal cerebellar cortex.  Environ. Res. 26:281‑306, 1981.

  193. Chang, L.W., P.R. Wade and G.W. Lee.  An ultrastructural re-evaluation on lead induced pathology in the kidney.  EnvironRes. 26:136‑151, 1981.

  194. Chang, L.W., K.R. Reuhl and P.R. Wade.  Pathological effects of cadmium. In: Biogeochemistry of Cadmium.  II. Health Effects.  Ed. J.O. Nriagu. New York: Elsevier Publ., pp. 783‑840, 1981

  195. Chang, L.W., P.R. Wade, K.R. Reuhl and M.J. Olson.  Ultrastructural changes in renal proximal tubules after tetraethyl lead intoxication. EnvironRes. 23:208‑223, 1980.

  196. Chang, L.W., J.G. Pounds, K.R. Reuhl and P.R. Wade.  Prenatal and neonatal toxicity and pathology of heavy metals.  In:Advances in Pharmacology and Chemotherapy, Vol. 17.  Eds.  A. Goldin, F.      Hawking, I.J. Kopin, and R.J. Schnitzer.  New York: Academic Press,    pp. 195‑231, 1980.

  197. Chang, L.W. and C.C. Kao.  An ultrastructural study on the reactive oligodendrocytes, myeloclasts, and myelophages in transected dog spinal cord.  NeurolRes. 1:349‑367, 1980.

  198. Chang, L.W.  Neurotoxic effects of mercury.  In: Experimental and Clinical Neurotoxicology.  Eds. P.S. Spencer and H.H. Schaumberg.  Baltimore: Williams and Wilkins Publ., pp. 508‑526, 1980.

  199. Chang, L.W. and H.M. Payan.  Cobalt‑induced epilepsy ‑ an ultrastructural study.  NeurolRes. 1:19‑29, 1979.

  200. Reuhl, K.R. and L.W. Chang.  Effects of methylmercury on the development of the nervous system ‑ a review.  Neurotoxicology1:21‑55, 1979.

  201. Chang, L.W.  Pathological effect of mercury poisoning.  In: Biogeochemistry of Mercury.  Ed. J.O. Nriagu.  New York: Elsevier Publ., pp. 519‑580, 1979.

  202. Chang, L.W. and P.A. Desnoyers.  Methylmercury induced biochemical and microsomal changes in the rat liver.  JEnvironPatholToxicol. 1:569‑579, 1978.

  203. Chang, L.W., M.M. Gilbert and J.A. Sprecher.  Modification of the neurotoxic effects of methylmercury by vitamin E.  Environ.Res. 17:356‑366, 1978.

  204. Bozelka, B.E., P.M. Burkholder and L.W. Chang.  Cadmium ‑ a metallic inhibitor of antibody mediated immunity in mice.  Environ.Res. 17:390‑402, 1978.

  205. McDonel, J.L., L.W. Chang, J.G. Pounds and C.L. Duncan.  The effects of clostridium perifringens enterotoxin on rat and rabbit ilium: an electron microscopic study.  LabInvest. 39:210‑218, 1978.

  206. Chang, L.W.  Pathological changes following halothane exposure ‑ a review.  EnvironHealth Perspec. 21:195‑210, 1977.

  207. Dudley, A.W., Jr., L.W. Chang, M.A. Dudley, R. Bowman and J. Katz. Review of effects of chronic exposure to low levels of halothane.  In: Neurotoxicology.  Eds. L. Roizin, H. Shiraki and N. Grcevic.  New York: Raven Press, pp. 137‑145, 1977.

  208. Chang, L.W., A.W. Dudley, Jr., M.A. Dudley, H.E. Ganther and M.L. Sunde. Modification of the neurotoxic effects of methylmercury by selenium. In: Neurotoxicology.  Eds. L. Roizin, H. Shiraki and N. Grcevic.  New York: Raven Press, pp. 275‑285, 1977.

  209. Chang, L.W.  Neurotoxic effects of mercury ‑ a review.  EnvironRes. 14:329‑373, 1977.

  210. Chang, L.W., K.R. Reuhl and G.W. Lee.  Electron microscopic evidence of degenerative changes in the developing nervous system as a result of in utero exposure to methylmercury.  Environ. Res. 14:414‑423, 1977.

  211. Chang, L.W., K.R. Reuhl and J.M. Spyker.  Ultrastructural study of the long‑term effects of methylmercury on the nervous system after prenatal exposure.  EnvironRes. 13:171‑185, 1977.

  212. Kao, C.C., L.W. Chang and J.M.B. Bloodworth.  Axonal regeneration across transected, mammalian spinal cords: an electron microscopic study of delayed nerve grafting.  Exp. Neurol. 54:591‑615, 1977.

  213. Kao, C.C., L.W. Chang and J.M.B. Bloodworth.  The mechanism of spinal cord cavitation following spinal cord transection.  Part III. Delayed grafting with and without spinal cord transection.  JNeurosurg. 46:757‑766, 1977.

  214. Kao, C.C., L.W. Chang and J.M.B. Bloodworth.  The mechanism of spinal cord cavitation following spinal cord transection.  Part II. Electron microscopic observations.  JNeurosurg. 46:745‑756, 1977.

  215. Kao, C.C., L.W. Chang and J.M.B. Bloodworth.  Electron microscopic observations of the mechanisms of terminal club formation in transected spinal cord axons.  JNeuropathExpNeurol. 36:140‑156, 1977.

  216. Kao, C.C. and L.W. Chang.  The mechanism of spinal cord cavitation following spinal cord transection.  Part I. A correlated histochemical study.  JNeurosurg. 46:197‑209, 1977.

  217. Chang, L.W., H.E. Ganther, A.W. Dudley and M.L. Sunde.  Modification of neuropathology of methylmercury by dietary selenium.  Food ResInstAnnual Report, Univ. of Wisconsin, pp. 382‑383, 1976.

  218. Ganther, H.E., L.W. Chang, A.W. Dudley and M.L. Sunde.  Modification of methylmercury toxicity and metabolism in cats fed tuna compared to pike.  Food ResInstAnnual Report, Univ. of Wisconsin, pp. 374‑381, 1976.

  219. Chang, L.W. and J. Katz.  Pathological effects of chronic halothane inhalation ‑ an overview.  Anesthesiology 4:640‑655, 1976.

  220. Chang, L.W. and J.A. Sprecher.  Hyperplastic changes in the rat renal tubular epithelial cells following in utero exposure to methylmercury.  EnvironRes. 12:218‑223, 1976.

  221. Chang, L.W. and J.A. Sprecher.  Degenerative changes in the neonatal kidney following in utero exposure to methylmercury.  Environ. Res. 11:392‑406, 1976.

  222. Chang, L.W., L.M. Mak and A.H. Martin.  Dose‑dependent effects of methylmercury on limb regeneration of newts (Triturus Viridescens). EnvironRes. 11:305‑309, 1976.

  223. Chang, L.W. and J.A. Sprecher.  Pathological changes in the kidney after methylcadmium intoxication.  EnvironRes. 12:92‑109, 1976.

  224. Chang, L.W., A.W. Dudley, Jr. and J. Katz.  Pathological changes in the nervous system following in utero exposure to halothane.  EnvironRes. 11:40‑51, 1976.

  225. Chang, L.W., A.W. Dudley, Jr., Y.K. Lee and J. Katz.  Ultrastructural studies of the hepatocytes after chronic exposure to low levels of halothane.  ExpMolecular Pathol.  23:35‑42, 1975.

  226. Chang, L.W., Y.K. Lee, A.W. Dudley, Jr. and J. Katz. Ultrastructural evidence of hepatotoxicity of halothane in rats following in utero exposure. CanadAnesthSoc. J. 22:330‑338,    1975.

  227. Dudley, A.W., L.W. Chang, H.E. Ganther and M.L. Sunde.  Modification of methylmercury toxicity in cats by varying the intake of dietary selenium of fish origin.   Food ResInstAnnual Report, Univ. of Wisconsin, pp.350‑353, 1975.

  228. Ganther, H.E., A.W. Dudley, L.W. Chang and M.L. Sunde.  Mercury, selenium and glutathione peroxidase in cats fed pike or tuna diets with and without supplemental methylmercury.  Food ResInstAnnual Report, Univ. of Wisconsin, pp. 346‑349, 1975.

  229. Desnoyers, P.A. and L.W. Chang.  Ultrastructural changes of the liver after chronic exposure to methylmercury.  EnvironRes. 10:59‑75, 1975.

  230. Chang, L.W., A.W. Dudley, Jr., Y.K. Lee and J. Katz.  Ultrastructural studies on the pathological changes in the neonatal kidney following in utero exposure in halothane.  EnvironRes. 10:174‑189, 1975.

  231. Ware, R.A., P.M. Burkholder and L.W. Chang.  Ultrastructural changes in renal proximal tubules after chronic organic and inorganic mercury intoxication.  EnvironRes. 10:121‑140, 1975.

  232. Desnoyers, P.A. and L.W. Chang.  Ultrastructural changes in the hepatocytes following acute methylmercury intoxication.  Environ.Res. 9:224‑239, 1975.

  233. Chang, L.W., A.W. Dudley, Jr., Y.K. Lee and J. Katz.  Ultrastructural changes in the kidney following chronic exposure to low levels of halothane.  AmJPathol. 78:225‑242, 1975.

  234. Ware, R.A., L.W. Chang and P.M. Burkholder.  An ultrastructural study in the blood‑brain barrier dysfunction in mercury intoxication.  Acta Neuropath. 30:211‑242, 1975.

  235. Chang, L.W., A.W. Dudley, Jr., Y.K. Lee and J. Katz.  Ultrastructural changes in the nervous system after chronic exposure to halothane.  ExpNeurol. 45:209‑210, 1974.

  236. Ware, R.A., L.W. Chang and P.M. Burkholder.  Ultrastructural evidence for fetal liver injury induced by in utero exposure to small doses of methylmercury.  Nature 251:236‑237, 1974.

  237. Quimby, K.L., L.J. Aschkenase, R.E. Bowman, J. Katz and L.W. Chang.  Enduring learning deficits and cerebral synaptic malformation from exposure to 10 ppm halothane.  Science 185:625‑627, 1974.

  238. Chang, L.W., A.W. Dudley, Jr. and C.E. Potter.  A silver method for the study and demonstration of cellular injury.  Histo‑Logic 4:47‑48, 1974.

  239. Chang, L.W.  A proposed pathogenetic mechanism for the neurotoxicity of mercury, recent findings and a review.  First Internat'lCongress of Mercury.  Barcelona, Spain, pp. 1‑30, 1974.

  240. Chang, L.W., K.R. Reuhl and A.W. Dudley, Jr.  Effects of methylmercury on Rana Pipiens tadpoles.  EnvironRes. 8:82‑91, 1974.

  241. Chang, L.W. and S. Yamaguchi.  Ultrastructural changes in the liver following long‑term diet of mercury contaminated tuna. EnvironRes. 7:133‑148, 1974.

  242. Chang, L.W., J.J. Lalich and A.W. Dudley, Jr.  Demonstration of lipids in paraffin sections.  Histo‑Logic 4:43‑44, 1974.

  243. Chang, L.W., J.M. Opitz, P.D. Pallister, E.F. Gilbert and C. Viseskul.  Minamata Disease ‑ a case report and a comparative study.  Acta Neuropath. 26:275‑284, 1973.

  244. Potter, C., L.W. Chang and A.W. Dudley, Jr.  Differential staining methods for cells in CNS.  Histo‑Logic 3:30‑31, 1973.

  245. Chang, L.W., E. Gilbert, W. Tanner and H.L. Moffat.  Reye's Syndrome ‑ Light and electron microscopic studies.  ArchPathol. 96:127‑132, 1973.

  246. Chang, L.W., P.A. Desnoyers and H.A. Hartmann.  Quantitative cytochemical studies of RNA in experimental mercury poisoning. II. Changes in base composition and ratios.  Acta Neuropathol. 23:77‑83, 1973.

  247. Chang, L.W., R.A. Ware and P.A. Desnoyers.  A histochemical study on some enzymatic changes in the kidney, liver, and brain after chronic mercury intoxication.  Food CosmetToxicol. 11:283‑286, 1973.

  248. Chang, L.W., A.H. Martin and H.A. Hartmann.  Quantitative autoradiographic  study on the RNA synthesis in the neurons after mercury intoxication.  ExpNeurol. 37:62‑67, 1972.

  249. Chang, L.W., P.A. Desnoyers and H.A. Hartmann.  Quantitative cytochemical studies of RNA in experimental mercury poisoning.  I.Changes in RNA content.  J. Neuropathol. Exp. Neurol. 32:489‑501,    1972.

  250. Chang, L.W. and H.A. Hartmann.  Ultrastructural studies of the nervous system after mercury intoxication.  II. Pathological changes in the nerve fibers.  Acta Neuropathol. 20:316‑334, 1972.

  251. Chang, L.W. and H.A. Hartmann.  Ultrastructural studies of the nervous system after mercury intoxication.  I. Pathological changes in the nerve cell bodies.  Acta Neuropathol. 20:122‑138, 1972.

  252. Chang, L.W. and H.A. Hartmann.  Blood‑brain barrier dysfunction in experimental mercury intoxication.  Acta Neuropathol.21:179‑184, 1972.

  253. Chang, L.W. and H.A. Hartmann.  Electron microscopic histochemical study on the localization and distribution of mercury in the nervous system after mercury intoxication.  ExpNeurol. 35:122‑137, 1972.

  254. Chang, L.W.  A thermal study of metachromasia.  M.S. Thesis, Tufts University, Medford, Massachusetts, 1969.

  255. Kelly, J.W., L.W. Chang and F. Rothstein.  Thermal analysis of polyanion metachromasia.  Temperature effect on metachromatic solutions of nucleic acids and acid mucopolysaccharides.  J. Histochem. Cytochem. 17:658‑667, 1969.

  256. Kelly, J.W. and L.W. Chang.  Thermal analysis of polyanion metachomasia.Temperature effect on stained cells, tissue and models.  J. Histochem. Cytochem. 17:651‑657, 1969.

 

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