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蘇五洲 Wu-Chou Su

Wu-Chou,Su

蘇五洲  內科學科 教授(Wu-Chou Su)

E-mail:sunnysu@mail.ncku.edu.tw

電話:06-2353535 分機3107

傳真:06-2084112

 

學經歷

 

學歷 1976/07 - 1983/06   國立台灣大學醫學系醫學士
   

 

現職 2019/02 - now   成大醫院腫瘤醫學部 主任
  2018/01 - now   國立成功大學 奈米醫學研究中心 主任
  2017/08 - now   成大醫院內科部 主任
  2004/08 - now   國立成功大學醫學系內科學科 教授
  2004/07 - now   成大醫院內科部血液腫瘤科 主任
  1990/08 - now   成大醫院內科部 主治醫師
 
 
經歷 2019/02 - now   成大醫院腫瘤醫學部 主任
  2018/01 - now   國立成功大學奈米醫學研究中心 主任
  2017/08 - now   成功醫院內科部 主任
  2011/10 - 2017/07   成大醫院癌症中心 主任
  2006/01 - 2011/09   成大醫院臨床試驗中心 主任
  2004/08 - now   國立成功大學醫學系內科學科 教授
  2004/07 - now   成大醫院內科部血液腫瘤科 主任
  1997/07 - 2004/07   國立成功大學醫學系內科學科 副教授
  1995/08 - 1997/05   美國耶魯大學病理部 研究員
  1990/08 - now   成大醫院內科部 主治醫師
  1988/08 - 1990/07   中央研究院生物醫學科學研究所腫瘤專科醫師訓練
  1987/08 - 1990/07   成大醫院內科部 住院醫師
  1985/08 - 1989/07   台大醫院內科部 住院醫師
 

專長

   

肺癌、細胞內訊息傳遞、奈米醫學

研究興趣

   

 

  1. 研究IL6/Jak/Stat pathway和肺癌病態生理學的關係
  2. IL6醣化與肺癌轉移的關係
  3. 發展以奈米材料攜帶藥物和基因進行癌症的治療
 

榮譽獎項

   

 

  1. 第九屆 奈米產業科技菁英獎-學術類:「臨床導向奈米生技之轉譯研發,由微觀智慧型與診療一體到個人化醫療的實踐」
  2. 第十三屆 國家新創獎-學研新創組:「具CT/MRI雙顯影與癌細胞放射治療敏感度偵測並?敏功能之創新奈米粒子」
  3. 第十四屆 國家新創獎-學研新創組:「光學基因剪切技術:分子、細胞及活體之多層次基因編輯應用」


近五年代表作
:

  1. Roy S. Herbst, Edward B. Garon, Dong-Wan Kim, Byoung Chul Cho, Jose L. Perez-Gracia, Ji-Youn Han, Catherine Dubos Arvis, Margarita Majem, Martin D. Forster, Isabelle Monnet, Silvia Novello, Zsuzsanna Szalai, Matthew A. Gubens, Wu-Chou Su, Giovanni Luca Ceresoli, Ayman Samkari, Erin H. Jensen, Gregory M. Lubiniecki, Paul Baas. Long-term outcomes and retreatment among patients with previously treated, programmed death-ligand 1-positive, advanced non-small-cell lung cancer in the KEYNOTE-010 Study. Journal of Clinical Oncology (2020 in press)
  2. Lecia V Sequist, Ji-Youn Han, Myung-Ju Ahn, Byoung Chul Cho, Helena Yu, Sang-We Kim, James Chih-Hsin Yang, Jong Seok Lee, Wu-Chou Su, Dariusz Kowalski, Sergey Orlov, Geoffrey Oxnard et al. Osimertinib plus savolitinib in patients with EGFR mutation-positive, MET-amplified, non-small-cell lung cancer after progression on EGFR tyrosine kinase inhibitors: interim results from a multicentre, open-label, phase 1b study. The Lancet Oncology 2020; 21(3): 373-386.
  3. Po-Lan Su, Szu-Chun Yang, Yi-Lin Chen, Yi-Lin Wu, Chia-Ying Lin, Wei-Yuan Chang, Yau-Lin Tseng, Wu-Wei Lai, Chung-Liang Ho*, Chien-Chung Lin*, Wu-Chou Su*. Real-world outcomes of NSCLC patients receiving tissue or circulating tumor DNA-guided osimertinib treatment. Cancer Medicine 2019; 8(13): 5939-5947.
  4. Li-Xing Yang, Ya-Na Wu, Pei-Wen Wang, Wu-Chou Su*, Dar-Bin Shieh*. Iron release profile of Silica-modified zero-valent iron NPs and their implication in cancer therapy. International Journal of Molecular Sciences 2019; 20(18): 4336.
  5. Fang Wei, Charles M. Strom, Jordan Cheng, Chien-Chung Lin, Ching-Yun Hsu, Guy W. Soo Hoo, David Chia, Yong Kim, Feng Li, David Elashoff, Tristan Grognan, Michael Tu, Wei Liao, Rena Xian, Wayne W. Grody, Wu-Chou Su*, David T.W. Wong*. Electric field-induced release and measurement liquid biopsy for noninvasive early lung cancer assessment. Journal of Molecular Diagnostics 2018; 20(6): 738-742.
  6. Kundan Sivashanmugana#, Wei-Lun Huang#, Chen-Hsueh Lin, Jiunn-Der Liao, Chien-Chung Lin, Wu-Chou Su*, Ten-China Wen*. Bimetallic nanoplasmonic gap-mode SERS substrate for lung normal and cancer-derived exosomes detection. Journal of the Taiwan Institute of Chemical Engineers 2017; 80: 149-155.
  7. Tsung-Lin Tsai, Hao-Chen Wang, Chun-Hua Hung, Peng-Chan Lin, Yi-San Lee, Helen H.W. Chen*, Wu-Chou Su*. Wheat germ agglutinin-induced paraptosis-like cell death and protective autophagy is mediated by autophagy-linked FYVE inhibition. Oncotarget 2017; 8(53): 91209-91222.
  8. Tsung-Ju Li, Chen-Min Chang, Po-Yang Chang, Yu-Chun Chuang, Chih-Chia Huang*, Wu-Chou Su*, Dar-Bin Shieh*. Handheld energy-efficient magneto-optical real-time quantitative PCR device for target DNA enrichment and quantification. NPG Asia Materials 2016; 8, e277.
  9. Chien-Chung Lin, Wei-Lun Huang, Fang Wei, Wu-Chou Su*, David T. Wong*. Emerging platforms using liquid biopsy to detect EGFR mutations in lung cancer. Expert Review of Molecular Diagnostics 2015; 15(11): 1427-1440.
  10. Wei-Lun Huang, Fang Wei, David T. Wong, Chien-Chung Lin*, Wu-Chou Su*. The emergent landscape of detecting EGFR mutations using circulating tumor DNA in lung cancer. BioMed Research International (formerly titled Journal of Biomedicine and Biotechnology) 2015; 2015: 340732.
  11. I-Fang Cheng, Wei-Lun Huang, Tzu-Ying Chen, Chien-Wei Liu, Yu-De Lin, Wu-Chou Su*. Antibody-free isolation of rare cancer cells from blood based on 3D lateral dielectrophoresis. Lab on a Chip 2015; 15(14): 2950-2959.
  12. Fang Wei, Chien-Chung Lin, Aron Joon, Ziding Feng, Gabriel Troche, Maruja E Lira, David Chia, Mao Mao, Chung-Liang Ho, Wu-Chou Su*, David T.W. Wong*. Non-invasive saliva-based EGFR gene mutation detection in lung cancer patients. American Journal of Respiratory and Critical Care Medicine 2014; 190(10): 1117-1126.
  13. Wei-Hsin Chiu, Helen Hai-Wen Chen, Jang-Yang Chang, Sheng-Jie Luo, Chia-Ling Li, Chia-Ling Chen, Wu-Chou Su*, Chiou-Feng Lin*. Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells. Cancer Letters 2014; 349(2): 144-151.
 
 

研究成果 (Publications) -- Wu-Chou Su

 
  1. Makoto Nishio, Enriqueta Felip, Sergey Orlov, Keunchil Park, Chong-Jen Yu, Chun-Ming Tsai, Manuel Cobo, Mark McKeage, Wu-Chou Su, Tony Mok, Giorgio V. Scagliotti, David R. Spigel, Kalyanee Viraswami-Appanna, Zhe Chen, Vanessa Q. Passos, Alice T. Shaw. Final overall survival and other efficacy and safety results from ASCEND-3: phase II study of Ceritinib in ALKi-naive patients with ALK-rearranged NSCLC. Journal of Thoracic Oncology (2020 in press)
  2. Roy S. Herbst, Edward B. Garon, Dong-Wan Kim, Byoung Chul Cho, Jose L. Perez-Gracia, Ji-Youn Han, Catherine Dubos Arvis, Margarita Majem, Martin D. Forster, Isabelle Monnet, Silvia Novello, Zsuzsanna Szalai, Matthew A. Gubens, Wu-Chou Su, Giovanni Luca Ceresoli, Ayman Samkari, Erin H. Jensen, Gregory M. Lubiniecki, Paul Baas. Long-term outcomes and retreatment among patients with previously treated, programmed death-ligand 1-positive, advanced non-small-cell lung cancer in the KEYNOTE-010 Study. Journal of Clinical Oncology (2020 in press)
  3. Hsin-Yi Wu, Yu-Yi Pan, Arthur T. Kopylov, Victor Zgoda, Mi-Chia Ma, Ching-Hsun Wang, Wu-Chou Su, Wu-Wei Lai, Pin-Nan Cheng, Pao-Chi Liao. Assessment of serological early biomarker candidates for lung adenocarcinoma by using multiple reaction monitoring-mass spectrometry. Proteomics Clinical Application (2020 in press)
  4. Yuh-Min Chen, James Chih-Hsin Yang, Wu-Chou Su, Inn-Wen Chong, Te-Chun Hsia, Meng-Chih Lin, Gee-Chen Chang, Chao-Hua Chiu, Chao-Chi Ho, Shang-Yin Wu, Jen-Yu Hung, Chin-Chou Wang, Tsung-Ying Yang, Chong-Jen Yu. Nivolumab safety and efficacy in advanced, platinum-resistant, non-small cell lung cancer, radical radiotherapy-ineligible patients: A phase II study in Taiwan. Journal of the Formosan Medical Association (2020 in press)
  5. Lecia V Sequist, Ji-Youn Han, Myung-Ju Ahn, Byoung Chul Cho, Helena Yu, Sang-We Kim, James Chih-Hsin Yang, Jong Seok Lee, Wu-Chou Su, Dariusz Kowalski, Sergey Orlov, Mireille Cantarini, Remy B Verheijen, Anders Mellemgaard, Lone Ottesen, Paul Frewer, Xiaoling Ou, Geoffrey Oxnard. Osimertinib plus savolitinib in patients with EGFR mutation-positive, MET-amplified, non-small-cell lung cancer after progression on EGFR tyrosine kinase inhibitors: interim results from a multicentre, open-label, phase 1b study. The Lancet Oncology 2020 Mar; 21(3): 373-386.
  6. Jason Y.Y. Wong, Han Zhang, Chao A. Hsiung, Kouya Shiraishi, Wu-Chou Su, Qing Lan et al. Tuberculosis infection and lung adenocarcinoma: mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women. Genomics 2020 Mar; 112(2): 1223-1232.
  7. YungJue Bang, WuChou Su, Martin Schuler, DoHyun Nam, Wan Teck Lim, Todd M. Bauer, Analia Azaro, Ronnie Tung Ping Poon, David Hong, ChiaChi Lin, Mikhail Akimov, Samson Ghebremariam, Sylvia Zhao, Monica Giovannini, Brigette Ma. Phase 1 study of capmatinib in METpositive solid tumor patients: Dose escalation and expansion of selected cohorts. Cancer Science 2020 Feb; 111(2): 536-547.
  8. Li-Hsin Chien, Chung-Hsing Chen, Tzu-Yu Chen, Gee-Chen Chang, Ying-Huang Tsai, Chin-Fu Hsiao, Kuan-Yu Chen, Wu-Chou Su, Wen-Chang Wang, Ming-Shyan Huang, Yuh-Min Chen, Chih-Yi Chen, Sheng-Kai Liang, Chung-Yu Chen, Chih-Liang Wang, Mei-Hsuan Lee, Ren-Hua Chung, Fang-Yu Tsai, Jia-Wei Hu, Hormuzd A. Katki, Nilanjan Chatterjee, Stephen J. Chanock, Nathaniel Rothman, Qing Lan, Pan-Chyr Yang, Chien-Jen Chen, I-Shou Chang, Chao A. Hsiung. Predicting lung cancer occurrence in never-smoking females in Asia: TNSF-SQ, a prediction model. Cancer Epidemiology Biomarkers & Prevention 2020 Feb 29(2): 452-459.
  9. Szu-Chun Yang, Chin-Wei Kuo, Wu-Wei Lai, Chien-Chung Lin, Wu-Chou Su, Sheng-Mao Chang, Jung-Der Wang. Dynamic changes of health utility in lung cancer patients receiving different treatments: a 7-year follow-up. Journal of Thoracic Oncology 2019 Nov; 14(11): 1892-1900.
  10. Jhanelle E. Gray, Isamu Okamoto, Virote Sriuranpong, Johan F. Vansteenkiste, Fumio Imamura, Jong-Seok Lee, Yong-Kek Pang, Manuel Cobo, Kazuo Kasahara, Ying Cheng, Naoyuki Nogami, Eun Kyung Cho, Wu-Chou Su, Guili Zhang, Xiangning Huang, Xiaocheng Li-Sucholeiki, Brian Lentrichia, Simon P. Dearden, Suzanne Jenkins, Matilde Saggese, Yuri Rukazenkov, Suresh Ramalingam. Tissue and plasma EGFR mutation analysis in the FLAURA trial: Osimertinib vs comparator EGFR-TKI as first-line treatment in patients with EGFR mutated advanced NSCLC. Clinical Cancer Research 2019 Nov; 25(22): 6644-6652.
  11. Po-Lan Su, Szu-Chun Yang, Yi-Lin Chen, Yi-Lin Wu, Chia-Ying Lin, Wei-Yuan Chang, Yau-Lin Tseng, Wu-Wei Lai, Chung-Liang Ho*, Chien-Chung Lin*, Wu-Chou Su*. Real-world outcomes of NSCLC patients receiving tissue or circulating tumor DNA-guided osimertinib treatment. Cancer Medicine 2019 Oct; 8(13): 5939-5947.
  12. Li-Xing Yang, Ya-Na Wu, Pei-Wen Wang, Wu-Chou Su*, Dar-Bin Shieh*. Iron release profile of Silica-modified zero-valent iron NPs and their implication in cancer therapy. International Journal of Molecular Sciences 2019 Sep; 20(18): 4336.
  13. Chia-Ying Lin, Chao-Chun Chang, Po-Lan Su, Chien-Chung Lin, Yau-Lin Tseng, Wu-Chou Su, Yi-Ting Yen. Brain MRI imaging characteristics predict treatment response and outcome in patients with de novo brain metastasis of EGFR-mutated NSCLC. Medicine 2019 Aug; 98(33): e16766.
  14. Yi-Lin Chen, Chien-Chung Lin, Shu-Ching Yang, Wan-Li Chen, Jian-Rong Chen, Yi-Hsin Hou, Cheng-Chan Lu, Nan-Haw Chow, Wu-Chou Su, Chung-Liang Ho. Five technologies for detecting the EGFR T790M mutation in the circulating cell-free DNA of patients with non-small cell lung cancer: a comparison. Frontiers in Oncology 2019 Jul; 9: 631.
  15. Chia-Chi Lin, Hendrik-Tobias Arkenau, Sharon Lu, Jasgit Sachdev, Javier de Castro Carpeno, Monica Mita, Rafal Dziadziuszko, Wu-Chou Su, Dmitri Bobilev, Lorraine Hughes, Jian Chan, Zhi-Yi Zhang, Glen J. Weiss. A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas. British Journal of Cancer 2019 Jul; 121(2): 131-138.
  16. James Chih-Hsin Yang, Shirish M. Gadgeel, Lecia Van Dam Sequist, Chien-Liang Wu, Vassiliki A. Papadimitrakopoulou, Wu-Chou Su, Joseph Fiore, Sanatan Saraf, Harry Raftopoulos, Amita Patnaikh. Brief report: Pembrolizumab in combination with Erlotinib or Gefitinib as first-line therapy for advanced non-small-cell lung cancer with sensitizing EGFR mutation. Journal of Thoracic Oncology 2019 Mar; 14(3): 553-559.
  17. Helen H. W. Chen, Wu-Chou Su, How-Ran Guo, Bi-Fang Lee, Nan-Tsing Chiu. Prognostic value of volumetric metabolic parameter changes determined by during and after radiotherapy-based 18F-FDG PET/CT in stage III non-small cell lung cancer. Kaohsiung Journal of Medical Sciences 2019 Mar; 35(3): 151-159.
  18. Chung-Ying Lin, Jing-Shiang Hwang, Wen-Chung Wang, Wu-Wei Lai, Wu-Chou Su, Tzu-Yi Wu, Grace Yao, Jung-Der Wang. Psychometric evaluation of the WHOQOL-BREF, Taiwan version, across five kinds of Taiwanese cancer survivors: Rasch analysis and confirmatory factor analysis. Journal of the Formosan Medical Association 2019 Jan; 118(1): 215-222.
  19. Thomas John, Hiroaki Akamatsu, Angelo Delmonte, Wu-Chou Su, Jong Seok Lee, Gee-Chen Chang, Xiangning Huang, Suzanne Jenkins, Yi-Long Wu. EGFR mutation analysis for prospective patient selection in AURA3 phase III trial of osimertinib versus platinum-pemetrexed in patients with EGFR T790M-positive advanced non-small-cell lung cancer. Lung Cancer 2018 Dec; 126: 133-138.
  20. Yu-Feng Wei, Chang-Yao Chu, Chao-Chun Chang, Sheng-Hsiang Lin, Wu-Chou Su, Yau-Lin Tseng, Chien-Chung Lin, Yi-Ting Yen. Different pattern of PD-L1, IDO, and FOXP3 Tregs expression with survival in thymoma and thymic carcinoma. Lung Cancer 2018 Nov; 125: 35-42.
  21. Fang Wei, Charles M. Strom, Jordan Cheng, Chien-Chung Lin, Ching-Yun Hsu, Guy W. Soo Hoo, David Chia, Yong Kim, Feng Li, David Elashoff, Tristan Grognan, Michael Tu, Wei Liao, Rena Xian, Wayne W. Grody, Wu-Chou Su*, David T.W. Wong*. Electric field-induced release and measurement liquid biopsy for noninvasive early lung cancer assessment. Journal of Molecular Diagnostics 2018 Nov; 20(6): 738-742.
  22. Yi-Long Wu, Li Zhang, Dong-Wan Kim, Xiaoqing Liu, Dae Ho Lee, James Chih-Hsin Yang, Myung-Ju Ahn, Johan F. Vansteenkiste, Wu-Chou Su, Enriqueta Felip, Vincent Chia, Sabine Glaser, Philippe Pultar, Sylvia Zhao, Bin Peng, Mikhail Akimov, Daniel S.W. Tan. Phase Ib/II Study of Capmatinib (INC280) plus Gefitinib after failure of Epidermal Growth Factor Receptor (EGFR) inhibitor therapy in patients with EGFR-mutated, MET factor-dysregulated non-small-cell lung cancer. Journal of Clinical Oncology 2018 Nov; 36(31): 3101-3109.
  23. Hong-Tai Tzeng, Ching-Chin Su, Chih-Peng Chang, Wu-Wei Lai, Wu-Chou Su, Yi-Ching Wang. Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages towards tumor-suppressing phenotype. International Journal of Cancer 2018 Oct; 143(7): 1753-1763.
  24. Po-Lan Su, Yi-Lin Wu, Wei-Yuan Chang, Chung-Liang Ho, Yau-Lin Tseng, Wu-Wei Lai, Wu-Chou Su, Chien-Chung Lin, Szu-Chun Yang. Preventing and treating brain metastases with three first-line EGFR-tyrosine kinase inhibitors in patients with EGFR mutation-positive advanced non-small cell lung cancer. Therapeutic Advances in Medical Oncology 2018 Sep; 10: 1758835918797589.
  25. Yan-Wei Wu, Chiou-Feng Lin, Yee-Shin Lin, Wu-Chou Su, Wei-Hsin Chiu. Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells. Cell Death Discovery 2018 Sep; 4: 96.
  26. Shu-Huei Cho, I-Ying Kuo, Pei-Jung Frank Lu, Hong-Tai Tzeng, Wu-Wei Lai, Wu-Chou Su, Yi-Ching Wang. Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness. Cell Death & Disease 2018 Aug; 9(9): 868.
  27. David E Gerber, Leora Horn, Michael Boyer, Rachel Sanborn, Ronald Natale, Ramon Palmero, Paolo Bidoli, Igor Bondarenko, Paul Germonpre, Doru Ghizdavescu, Athanasio Kotsaki, Herve Lena, György Losonczy, Kyunghee Park, Wu-Chou Su, Min Tang, Jennifer Lai, Niko Letta Kallinteris, Joseph S Shan, Martin Reck, David R Spigel. Randomized phase 3 study of docetaxel plus bavituximab in previously treated advanced non-squamous non-small-cell lung cancer. Annals of Oncology 2018 July; 29(7): 1548-1553.
  28. Chih-Chieh Yen, Hui-Chen Su, Chang-Yao Chu, Shi-Jie Lai, Jing-Jou Yana, Wen-Pin Su*, Wu-chou Su*. Excellent treatment response with pembrolizumab in a lung cancer patient who developed immune-mediated acute motor/sensory axonal polyneuropathy. Lung Cancer 2018 Jun; 120: 149-151.
  29. Szu-Chun Yang, Chien-Chung Lin, Wu-Wei Lai, Sheng-Mao Chang, Jing-Shiang Hwang, Wu-Chou Su, Jung-Der Wang. Dynamic changes in quality of life after three first-line therapies for EGFR mutation-positive advanced non-small-cell lung cancer. Therapeutic Advances in Medical Oncology 2018 Feb; 10: 1-11.
  30. Wei-Yuan Chang, Yi-Lin Wu, Po-Lan Su, Szu-Chun Yang*, Chien-Chung Lin*, Wu-Chou Su*. The impact of EGFR mutations on the incidence and survival of stages I to III NSCLC patients with subsequent brain metastasis. PLoS One 2018 Feb; 13(2): e0192161.
  31. Jean-Charles Soria, Yuichiro Ohe, Johan Vansteenkiste, Thanyanan Reungwetwattana, Busyamas Chewaskulyong, Ki Hyeong Lee, Arunee Dechaphunkul, Fumio Imamura, Naoyuki Nogami, Takayasu Kurata, Isamu Okamoto, Caicun Zhou, Byoung Chul Cho, Ying Cheng, Eun Kyung Cho, osimPei Jye Voon, David Planchard, Wu-Chou Su, Jhanelle E. Gray, Siow-Ming Lee, Rachel Hodge, Marcelo Marotti, Yuri Rukazenkov, Suresh S. Ramalingam, for the FLAURA Investigators. Osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer. New England Journal of Medicine 2018 Jan; 378(2): 113-125.
  32. Myung-Ju Ahn, Dong-Wan Kim, Byoung Chul Cho, Sang-We Kim, Jong Seok Lee, Jin-Seok Ahn, Tae Min Kim, Chia-Chi Lin, Hye Ryun Kim, Thomas John, Steven Kao, Jonathan W Goldman, Wu-Chou Su, Ronald Natale, Sarit Rabbie, Bryony Harrop, Philip Overend, Zhenfan Yang, James Chih-Hsin Yang. Activity and safety of AZD3759 in EGFR-mutant non-small-cell lung cancer with CNS metastases (BLOOM): a phase 1, open-label, dose-escalation and dose-expansion study. The Lancet Respiratory Medicine 2017 Nov; 5(11): 891-902.
  33. Kundan Sivashanmugana#, Wei-Lun Huang#, Chen-Hsueh Lin, Jiunn-Der Liao, Chien-Chung Lin, Wu-Chou Su*, Ten-China Wen*. Bimetallic nanoplasmonic gap-mode SERS substrate for lung normal and cancer-derived exosomes detection. Journal of the Taiwan Institute of Chemical Engineers 2017 Nov; 80, 149-155.
  34. Tsung-Lin Tsai, Hao-Chen Wang, Chun-Hua Hung, Peng-Chan Lin, Yi-San Lee, Helen H. W. Chen*, Wu-Chou Su*. Wheat germ agglutinin-induced paraptosis-like cell death and protective autophagy is mediated by autophagy-linked FYVE inhibition. Oncotarget 2017 Oct; 8(53): 91209-91222.
  35. Kenneth S. Thress, Vivien Jacobs, Helen K. Angell, James Chih-Hsin Yang, Lecia V. Sequist, Fiona Blackhall, Wu-Chou Su, Martin Schuler, Jurgen Wolf, Kathryn A. Gold, Mireille Cantarini, J. Carl Barrett, Pasi A. Jänne. Modulation of biomarker expression by osimertinib: Results of the paired tumor biopsy cohorts of the AURA Phase I trial. Journal of Thoracic Oncology 2017 Oct; 12(10): 1588-1594.
  36. Yu-Min Yeh, Shan-Ju Hsu, Peng-Chan Lin, Keng-Fu Hsu, Pei-Ying Wu, Wu-Chou Su, Jang-Yang Chang, Meng-Ru Shen. The c.1085A>G genetic variant of CSF1R gene regulates tumor immunity by altering the proliferation, polarization, and function of macrophages. Clinical Cancer Research 2017 Oct; 23(20): 6021-6030.
  37. Wen-Pin Su, Yen-Chih Ho, Cheng-Kuei Wu, Sen-Huei Hsu, Jia-Lin Shiu, Jheng-Cheng Huang, Song-Bin Chang, Wen-Tai Chiu, Jan-Jong Hung, Tsung-Lin Liu, Wei-Sheng Wu, Pei-Yu Wu, Wu-Chou Su, Jang-Yang Chang, Hungjiun Liaw. Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways. Scientific Reports 2017 Jun; 7: 3879.
  38. Szu-Chun Yang, Wu-Wei Lai, Chien-Chung Lin, Wu-Chou Su, Li-Jung Ku, Jing-Shiang Hwang, Jung-Der Wang. Cost-effectiveness of implementing computed tomography screening for lung cancer in Taiwan. Lung Cancer 2017 Jun; 108: 183-191.
  39. Chien-Wei Chen, Chin-Wei Kuo, Yi-Lin Chen, Chung-Liang Ho, Wu-Chou Su, Chien-Chung Lin. Successful AZD9291 therapy in advanced non-small cell lung cancer after failure of HM61713. Journal of Thoracic Oncology 2017 Jun; 12(6): e72-e74.
  40. Shao-An Wang, Yi-Chang Wang, Yun-Pei Chuang, Yi-Han Huang, Wu-Chou Su, Wen-Chang Chang, Jan-Jong Hung. EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis. Oncogene 2017 May; 36(21): 2930-2945.
  41. Jian-Ying Chuang, Wei-Lun Lo, C-Y Ko, S-Y Chou, R-M Chen, K-Y Chang, Jan-Jong Hung, Wu-Chou Su, Wen-Chang Chang, Tsung-I Hsu. Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma. Oncogenesis 2017 May; 6(5): e339.
  42. Chia-Sing Lu, Gia-Shing Shieh, Chung-Teng Wang, Bing-Hua Su, Yu-Chu Su, Yi-Cheng Chen, Wu-Chou Su, Pensee Wu, Wen-Horng Yang, Ai-Li Shiau, Chao-Liang Wu. Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer. Oncotarget 2017 May; 8(19): 30844-30858.
  43. Hong-Tai Tzeng, Chung-Han Tsai, Yi-Ting Yen, Hung-Chi Cheng, Yi-Chieh Chen, Shih-Wen Pu, Yu-Shiuan Wang, Yan-Shen Shan, Yau-Lin Tseng, Wu-Chou Su, Wu-Wei Lai, Li-Wha Wu*, Yi-Ching Wang*. Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via Thrombospondin-1 promotes tumor neovasculature and metastasis. Clinical Cancer Research 2017 May; 23(9): 2335-2345.
  44. James Chih-Hsin Yang, Myung-Ju Ahn, Dong-Wan Kim, Suresh S. Ramalingam, Lecia V. Sequist, Wu-Chou Su, Sang-We Kim, Joo-Hang Kim, David Planchard, Enriqueta Felip, Fiona Blackhall, Daniel Haggstrom, Kiyotaka Yoh, Silvia Novello, Kathryn Gold, Tomonori Hirashima, Chia-Chi Lin, Helen Mann, Mireille Cantarini, Serban Ghiorghiu, Pasi A. Janne. Osimertinib in pretreated T790M-positive advanced non-small-cell lung cancer: AURA study phase II extension component. Journal of Clinical Oncology 2017 Apr; 35(12): 1288-1296.
  45. Chung-Ying Lin, Szu-Chun Yang, Wu-Wei Lai, Wu-Chou Su, Jung-Der Wang. Rasch models suggested the satisfactory psychometric properties of the World Health Organization Quality of Life-Brief among lung cancer patients. Journal of Health Psychology 2017 Mar; 22(4): 397-408.
  46. Robin Kate Kelley, Chris Verslype, Allen L. Cohn, Tsai-Sheng Yang, Wu-Chou Su, Howard Burris, Fadi Braiteh, Nicholas Vogelzang, Alex Spira, Paul Foster, Y Lee, Eric Van Cutsem. Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinu-ation study. Annals of Oncology 2017 Mar; 28(3): 528-534.
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  110. Her-Shyong Shiah, Chang-Yi Chen, Chia-Yen Dai, Chin-Fu Hsiao, Yih-Jyh Lin, Wu-Chou Su, Jang-Yang Chang, Jacqueline Whang-Peng, Pin-Wen Lin, Jin-Ding Huang, Li-Tzong Chen. Randomised clinical trial: comparison of two everolimus dosing schedules in patients with advanced hepatocellular carcinoma. Alimentary Pharmacology & Therapeutics 2013 Jan; 37(1):62-73.
  111. Yi-Hsien Huang, Ming-Ping Wu, Shin-Chen Pan, Wu-Chou Su, Yi-Wen Chen, Li-Wha Wu. STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production. Angiogenesis 2013 Jan; 16(1):207-222.
  112. Wei-Pang Chung, Hsiang-Lin Song, Chung-Liang Ho, Nan-Tsing Chiu, Wu-Chou Su*. Gastric perforation secondary to regression of lung adenocarcinoma after gefitinib treatment. Journal of Clinical Oncology 2013 Jan; 31(1):e6-e8.
  113. Tsung-I Hsu, Mei-Chun Wang, Szu-Yu Chen, Shih-Ting Huang, Yu-Min Yeh, Wu-Chou Su, Wen-Chang Chang, Jan-Jong Hung. Betulinic acid decreases Sp1 level via increasing the sumoylation of Sp1 to inhibit lung cancer growth. Molecular Pharmacology 2012 Dec; 82(6):1115-1128.
  114. Wei-Hsin Chiu, Helen Hai-Wen Chen, Wu-Chou Su*. Oral vinorelbine: a better choice for concurrent chemoradiotherapy in stage III non-small cell lung cancer. Journal of Solid Tumors 2012 Nov; 2(6):4-15.
  115. Qing Lan, Chao A Hsiung, Keitaro Matsuo, Yun-Chul Hong, Wu-Chou Su, Nathaniel Rothman et al. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nature Genetics 2012 Nov; 44(12): 1330-1335.
  116. Wen-Pin Su, Ya-Chin Lo, Jin-Jou Yan, I-Chuang Liao, Pei-Jane Tsai, Hao-Chen Wang, Hsuan-Heng Yeh, Chien-Chung Lin, Helen H.W. Chen, Wu-Wei Lai, Wu-Chou Su*. Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells. Carcinogenesis 2012 Nov; 33(11):2065-2075.
  117. Shang-Yin Wu, Yu-Min Yeh, Ya-Ping Chen, Wu-Chou Su, Tsai-Yun Chen. Low incidence of thromboembolism in relapsed/refractory myeloma patients treated with thalidomide without thromboprophylaxis in Taiwan. Annals of Hematology 2012 Nov; 91(11):1773-1778.
  118. Tsung-Lin Tsai, Chia-Cheng Hou, Hao-Chen Wang, Zih-Syuan Yang, Chen-Sheng Yeh, Dar-Bin Shieh, Wu-Chou Su*. Nucleocytoplasmic transport blockage by SV40 peptide-modified gold nanoparticles induces cellular autophagy. International Journal of Nanomedicine 2012 Oct; 7:5215-5234.
  119. Chi-Yun Wang, Chia-Ling Chen, Yau-Lin Tseng, Yi-Ting Fang, Yee-Shin Lin, Wu-Chou Su, Chien-Chin Chen, Kung-Chao Chang, Yi-Ching Wang, Chiou-Feng Lin. Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms. Journal of Biological Chemistry 2012 Sep; 287(39):32512-32524.
  120. Wen-Pin Su, Fong-Yu Cheng, Dar-Bin Shieh, Chen-Sheng Yeh, Wu-Chou Su*. PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells. International Journal of Nanomedicine 2012 Aug; 7:4269-4283.
  121. Helen H.W. Chen, Nan-Tsing Chiu, Wu-Chou Su, How-Ran Guo, Bi-Fang Lee. Prognostic value of whole-body total lesion glycolysis at pretreatment FDG PET/CT in non-small cell lung cancer. Radiology 2012 Aug; 264(2):559-566.
  122. Tsung-I Hsu, Mei-Chun Wang, Szu-Yu Chen, Yu-Min Yeh, Wu-Chou Su, Wen-Chang Chang, Jan-Jong Hung. Sp1 expression regulates lung tumor progression. Oncogene 2012 Aug; 31(35):3973-3988.
  123. H. Dean Hosgood III, Wen-Chang Wang, Yun-Chul Hong, Jiu-Cun Wang, Wu-Chou Su, Qing Lan et al. Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia. Human Genetics 2012 Jul; 131(7): 1197-1203.
  124. Wei-Hsin Chiu, Sheng-Jei Luo, Chia-Ling Chen, Jai-Hong Cheng, Chia-Yuan Hsieh, Chi-Yun Wang, Wei-Ching Huang, Wu-Chou Su*, Chiou-Feng Lin. Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. Biochemical Pharmacology 2012 May; 83(9):1159-1171.
  125. Vincent A Miller, Vera Hirsh, Jacques Cadranel, Yuh-Min Chen, Keunchil Park, Sang-We Kim, Caicun Zhou, Wu-Chou Su, Mengzhao Wang, Yan Sun, Dae Seog Heo, Lucio Crino, Eng-Huat Tan, Tsu-Yi Chao, Mehdi Shahidi, Xiuyu Julie Cong, Robert M Lorence, James Chih-Hsin Yang. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncology 2012 May; 13(5):528-538.
  126. James Chih-Hsin Yang, Jin-Yuan Shih, Wu-Chou Su, Te-Chun Hsia, Chun-Ming Tsai, Sai-Hong Ignatius Ou, Chung-Jen Yu, Gee-Chen Chang, Ching-Liang Ho, Lecia V Sequist, Arkadiusz Z Dudek, Mehdi Shahidi, Xiuyu Julie Cong, Robert M Lorence, Pan-Chyr Yang, Vincent A Miller. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncology 2012 May; 13(5):539-548.
  127. Helen H.W. Chen, Jiang-Jou Yan, Wen-Chung Chen, Macus Tien Kuo, Yu-Hsuan Lai, Wu-Wei Lai, Hsiao-Sheng Liu, Wu-Chou Su*. Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy. Lung cancer 2012 Feb; 75(2):228-234.
  128. Helen H.W. Chen, Cheng-Yang Chou, Yuan-Hua Wu, Wei-Ting Hsueh, Chiung-Hui Hsu, How-Ran Guo, Wen-Ying Lee, Wu-Chou Su*. Constitutive STAT5 activation correlates with better survival in cervical cancer patients treated with radiation therapy. International Journal of Radiation Oncology Biology Physics 2012 Feb; 82(2):658-666.
  129. Peter Mu-Hsin Chang, Cheng-Hwai Tzeng, Ming-Huang Chen, Chao-Jung Tsao, Wu-Chou Su, Wei-Shuo Hwang, Yi-Fang Chang, Shyue-Yih Chang, Muh-Hwa Yang. Triweekly reduced-dose docetaxel combined with cisplatin in recurrent/metastatic head and neck squamous cell carcinoma: a multicenter phase II study. Cancer Chemotherapy and Pharmacology 2011 Dec; 68(6): 1477-1484.
  130. Chun-Hsiang Yu, Szu-Chun Yang, Wu-Wei Lai, Yi-Chuang Liao, Chung-Liang Ho, Wu-Chou Su, Hang-Yu Chang. Germ cell tumor with somatic-type malignancy presenting as right facial swelling in a young woman. Journal of Clinical Oncology 2011 Aug; 29(24):e699-e701.
  131. Hao-Chen Wang, Hsuan-Heng Yeh, Wei-Lun Huang, Chien-Chung Lin, Wen-Pin Su, Helen H. W. Chen, Wu-Wei Lai, Wu-Chou Su*. Activation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-β expression in lung adenocarcinoma cells. Molecular Endocrinology 2011 Jul; 25(7):1145-1158.
  132. Yun-Ju Chen, Wei-Chien Huang, Ya-Ling Wei, Sheng-Chieh Hsu, Ping Yuan, Heather Y. Lin, Ignacio I. Wistuba, J. Jack Lee, Chia-Jui Yen, Wu-Chou Su, Kwang-Yu Chang, Wen-Chang Chang, Tse-Chuan Chou, Chao-Kai Chou, Chang-Hai Tsai, Mien-Chie Hung. Elevated BCRP/ABCG2 expression confers acquired resistance to Gefitinib in wild-Type EGFR-expressing cells. PLoS One 2011 Jun; 6(6):e21428.
  133. Yen-Li Lo, Chin-Fu Hsiao, Yuh-Shan Jou, Gee-Chen Chang, Ying-Huang Tsai, Wu-Chou Su, Kuan-Yu Chen, Yuh-Min Chen, Ming-Shyan Huang, Wan-Shan Hsieh, Chien-Jen Chen, Chao A. Hsiung. Polymorphisms of MLH1 and MSH2 genes and the risk of lung cancer among never smokers. Lung Cancer 2011 Jun; 72(3):280-286.
  134. Kuo-Hsuan Hsu, Kun-Chieh Chen, Tsung-Ying Yang, Yi-Chen Yeh, Teh-Ying Chou, Hsuan-Yu Chen, Chi-Ren Tsai, Chih-Yi Chen, Chung-Ping Hsu, Jiun-Yi Hsia, Cheng-Yen Chuang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Chao A. Hsiung, Gee-Chen Chang, Chien-Jen Chen, Pan-Chyr Yang. Epidermal growth factor receptor mutation status in stage I lung adenocarcinoma with different image patterns. Journal of Thoracic Oncology 2011 Jun; 6(6):1066-1072.
  135. Chien-Chung Lin, Lien-Chin Chen, Vincent S. Tseng, Jing-Jou Yan, Wu-Wei Lai, Wen-Pin Su, Chi-Hung Lin, Chi-Ying F. Huang, Wu-Chou Su*. Malignant pleural effusion cells show aberrant glucose metabolism gene expression. European Respiratory Journal 2011 Jun; 37(6):1453-1465.
  136. Shi-Yi Yang, Tsung-Ying Yang, Kun-Chieh Chen, Yao-Jen Li, Kuo-Hsuan Hsu, Chi-Rne Tsai, Chih-Yi Chen, Chung-Ping Hsu, Jiun-Yi Hsia, Cheng-Yen Chuang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Chao Agnes Hsiung, Chen-Yang Shen, Gee-Chen Chang, Pan-Chyr Yang, Chien-Jen Chen. EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients. Clinical Cancer Research 2011 Apr; 17(8):2149-2158.
  137. Pei Kan, Chih-Wan Tsao, Ae-June Wang, Wu-Chou Su, Hsiang-Fa Liang. A liposomal formulation able to incorporate a high content of paclitaxel and exert promising anticancer effect. Journal of Drug Delivery 2011 Apr; 2011:629234.
  138. Shu-Yi Tsao, Kung-Chao Chang, Ya-Ping Chen, Yu-Min Yeh, Wu-Chou Su, Tsai-Yun Chen. Cytomegalovirus and Epstein-Barr virus-associated post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation. Annals of Hematology 2011 Jan; 90(1):113-114.
  139. Wen-Pin Su, Yen-Ting Chen, Wu-Wei Lai, Chien-Chung Lin, Jing-Jou Yan, Wu-Chou Su*. Apolipoprotein E expression promotes lung adenocarcinoma proliferation and migration and as a potential survival marker in lung cancer. Lung Cancer 2011 Jan; 71(1):28-33.
  140. Wei-Lun Huang, Hsuan-Heng Yeh, Chien-Chung Lin, Wu-Wei Lai, Jang-Yang Chang, Wen-Tsan Chang, Wu-Chou Su*. Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells. Molecular Cancer 2010 Dec; 9:309.
  141. Chien-Chung Lin, Wei-Lun Huang, Wen-Pin Su, Helen H. W. Chen, Wu-Wei Lai, Jing-Jou Yan, Wu-Chou Su*. Single cell phospho-specific flow cytometry can detect dynamic changes of phospho-Stat1 level in lung cancer cells. Cytometry Part A 2010 Nov; 77A(11):1008-1019.
  142. Tsung-Lin Tsai, Dar-Bin Shieh, Chen-Sheng Yeh, Yonhua Tzeng, Khant Htet, Kao-Shu Chuang, Jih Ru Hwu, Wu-Chou Su*. The down regulation of target genes by photo activated DNA nanoscissors. Biomaterials 2010 Sep; 31(25): 6545-6554.
  143. Chao Agnes Hsiung, Qing Lan, Yun-Chul Hong, Chien-Jen Chen, Wu-Chou Su, Dongxin Lin et al. The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genetics 2010 Aug; 6(8): e1001051.
  144. Yu-Min Yeh, Yi-Lin Chen, Hsieh-Yin Cheng, Wu-Chou Su, Nan-Haw Chow, Tsai-Yun Chen, Chung-Liang Ho. High percentage of JAK2 exon 12 mutation in Asian patients with polycythemia vera. American Journal of Clinical Pathology 2010 Aug; 134(2):266-270.
  145. Yen-Li Lo, Chin-Fu Hsiao, Yuh-Shan Jou, Gee-Chen Chang, Ying-Huang Tsai, Wu-Chou Su, Yuh-Min Chen, Ming-Shyan Huang, Hui-Ling Chen, Pan-Chyr Yang, Chien-Jen Chen, Chao A. Hsiung. ATM polymorphisms and risk of lung cancer among never smokers. Lung Cancer 2010 Aug; 69(2):148-154.
  146. Chi-Long Chen, Jan-Show Chu, Wu-Chou Su, Soon-Cen Huang and Wen-Ying Lee. Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX. Virchows Archiv 2010 Jul; 457(1):53-61.
  147. Ching-Liang Ho, Wu-Chou Su, Ruey-Kuen Hsieh, Zhong-Zhe Lin, Tsu-Yi Chao. A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone injection for the prevention of acute chemotherapy-induced nausea and vomiting. Japanese Journal of Clinical Oncology 2010 Apr; 40(4):294-301.
  148. Chi-Yun Wang, Yee-Shin Lin, Wu-Chou Su, Chia-Ling Chen, Chiou-Feng Lin. Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis. Molecular Biology of the Cell 2009 Oct; 20(19):4153-4161.
  149. Chin-Hao Chang, Chin-Fu Hsiao, Gee-Chen Chang, Ying-Huang Tsai, Yuh-Min Chen, Ming-Shyan Huang, Wu-Chou Su, Wan-Shan Hsieh, Pan-Chyr Yang, Chien-Jen Chen, Chao A. Hsiung. Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan. American Journal of Epidemiology 2009 Sep; 170(6):695-702.
  150. I-Lin Hsu, Wu-Chou Su, Jing-Jou Yan, Jia-Ming Changd, Wu-Wei Lai. Angiogenetic biomarkers in non-small cell lung cancer with malignant pleural effusion: correlations with patient survival and pleural effusion control. Lung Cancer 2009 Sep; 65(3):371-376.
  151. Yuh-Shan Jou, Yen-Li Lo, Chin-Fu Hsiao, Gee-Chen Chang, Ying-Huang Tsai, Wu-Chou Su, Yuh-Min Chen, Ming-Shyan Huang, Hui-Ling Chen, Chien-Jen Chen, Pan-Chyr Yang,Chao A. Hsiung. Association of an EGFR intron 1 SNP with never-smoking female lung adenocarcinoma patients. Lung Cancer 2009 Jun; 64(3):251-256.
  152. Kwang-Yu Chang, Meng-Ru Shen, Mei-Yi Lee, Wen-Lin Wang, Wu-Chou Su, Wen-Chang Chang, Ben-Kuen Chen. Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1β signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. Journal of Biological Chemistry 2009 Apr; 284(15):9908-9916.
  153. Hsuan-Heng Yeh, Raghavaraju Giri, Tsuey-Yu Chang, Cheng-Yang Chou, Wu-Chou Su*, Hsiao-Sheng Liu. Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell. DNA and Cell Biology 2009 Mar; 28(3):131-139.
  154. Shih-Chuan Hsiao, Wu-Chou Su*. Modified, weekly dosing with docetaxel and cisplatin as first-line therapy in advanced non-small cell lung cancer. National Medical Journal of India 2009 Mar; 22(2):67-69.
  155. Yu-Min Yeh, Ya-Ping Chen, Hung-Chang Wu, Wu-Chou Su, Tsai-Yun Chen. Cytomegalovirus-related neutropenic enterocolitis with negative CMV antigenemia as the initial presentation in an acute myeloid leukemia patient. Annals of Hematology 2009 Mar; 88(3):279-280.
  156. Yen-Li Lo, Yuh-Shan Jou, Chin-Fu Hsiao, Gee-Chen Chang, Ying-Huang Tsai, Wu-Chou Su, Kuan-Yu Chen, Yuh-Min Chen, Ming-Shyan Huang, Chi Yuan Hu, Chien-Jen Chen, Chao A. Hsiung. A polymorphism in the APE1 gene promoter is associated with lung cancer risk. Cancer Epidemiology, Biomarkers and Prevention 2009 Jan; 18(1):223-229.
  157. Jih Ru Hwu, Yu Sern Lin, Thainashmuthu Josephrajan, Ming-Hua Hsu, Fong-Yu Cheng, Chen-Sheng Yeh, Wu-Chou Su, Dar-Bin Shieh. Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles. Journal of the American Chemical Society 2009 Jan; 131(1):66-68.
  158. Ya-Ping Chen, Kung-Chao Chang, Wu-Chou Su, Tsai-Yun Chen. The expression and prognostic significance of platelet-derived growth factor receptor alpha in mature T- and natural killer-cell lymphomas. Annals of Hematology 2008 Dec; 87(12):985-990.
  159. Ping-Ching Wu, Chia-Hao Su, Fong-Yu Cheng, Jun-Cheng Weng, Jyh-Horng Chen, Tsung-Lin Tsai, Chen-Sheng Yeh, Wu-Chou Su, Jih Ru Hwu, Yonhua Tzeng, Dar-Bin Shieh. Modularly assembled magnetite nanoparticles enhance in vivo targeting for magnetic resonance cancer imaging. Bioconjugate Chemistry 2008 Oct; 19(10):1972-1979.
  160. Reury-Perng Perng, Chih-Hsin Yang, Yuh-Min Chen, Gee-Chen Chang, Meng-Chih Lin, Ruey-Kuen Hsieh, Nei-Min Chu, Ruay-Sheng Lai, Wu-Chou Su, Chao-Jung Tsao, Te-Chun Hsia, Hao-Cheng Chen, Chih-Hung Chen, Ming-Shyan Huang, Jui-Long Wang, Ming-Lin Ho, Chih-Yuan Chung, Chong-Jen Yu, Wen-Cheng Chang, Han-Pin Kuo, Chih-Teng Yu, Zhong-Zhe Lin, Woei-Yau Kao. High efficacy of erlotinib in Taiwanese NSCLC patients in an expanded access program study previously treated with chemotherapy. Lung Cancer 2008 Oct; 62(1):78-84.
  161. Chih-Chia Huang, Yi-Wei Lo, Wen-Shuo Kuo, Jih-Ru Hwu, Wu-Chou Su, Dar-Bin Shieh, Chen-Sheng Yeh. Facile preparation of self-assembled hydrogel-like GdPO4*H2O nanorods. Langmuir 2008 Aug; 24(15):8309-8313.
  162. Kuo-Wei Hu, Chih-Chia Huang, Jih-Ru Hwu, Wu-Chou Su, Dar-Bin Shieh, Chen-Sheng Yeh. A new photothermal therapeutic agent: core-free nanostructured Au x Ag1-x dendrites. Chemistry-A European Journal 2008 Mar; 14(10):2956-2964.
  163. Hsuan-Heng Yeh, Chin-Han Wu, Raghavaraju Giri, Ken Kato, Kimitoshi Kohno, Hiroto Izumi, Cheng-Yang Chou, Wu-Chou Su*, Hsiao-Sheng Liu. Oncogenic Ras-induced morphologic change is through MEK/ERK signaling pathway to downregulate Stat3 at a posttranslational level in NIH3T3 cells. Neoplasia 2008 Jan; 10(1):52-60.
  164. Jen-Hui Tsou, Kwang-Yu Chang, Wei-Chiao Wang, Joseph T. Tseng, Wu-Chou Su, Liang-Yi Hung, Wen-Chang Chang, Ben-Kuen Chen. Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2alpha in phorbol ester-treated non-small cell lung cancer A549 cells. Nucleic Acids Research 2008 Jan; 36(1):217-227.
  165. Kuan-Yu Chen, Chin-Fu Hsiao, Gee-Chen Chang, Yin-Huang Tsai, Wu-Chou Su, Reury-Perng Perng, Ming-Shyan Huang, Chao A. Hsiung, Chien-Jen Chen, Pan-Chyr Yang. Hormone replacement therapy and lung cancer risk in Chinese. Cancer 2007 Oct; 110(8):1768-1775.
  166. Chueh-Chuan Yen, Shu-Ching Liang, Yiin-Jeng Jong, Yann-Jang Chen, Chi-Hung Lin, Yuh-Min Chen, Yu-Chung Wu, Wu-Chou Su, Chi-Ying F. Huang, Szu-Wen Tseng, Jacqueline Whang-Peng. Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: different cytogenetic changes are correlated with genders and smoking habits. Lung Cancer 2007 Sep; 57(3):292-301.
  167. Helen H. W. Chen, Wu-Chou Su, Pin-Wen Lin, How-Ran Guo, Wen-Ying Lee. Hypoxia-inducible factor-1alpha correlates with MET and metastasis in node-negative breast cancer. Breast Cancer Research and Treatment 2007 Jun; 103(2):167-175.
  168. Wen-Pin Su, I-Hwi Tu, Shiao-Wen Hu, Hsuan-Heng Yeh, Dar-Bin Shieh, Tsai-Yun Chen, Wu-Chou Su*. HER-2/neu raises SHP-2, stops IFN-gamma anti-proliferation in bladder cancer. Biochemical and Biophysical Research Communications 2007 Apr; 356(1):181-186.
  169. Ying-Chih Pu, Jih Ru Hwu, Wu-Chou Su, Dar-Bin Shieh, Yonhua Tzeng, Chen-Sheng Yeh. Water-dissolvable sodium sulfate nanowires as a versatile template for the fabrication of polyelectrolyte- and metal-based nanotubes. Journal of the American Chemical Society 2006 Sep; 128(35):11606-11611.
  170. Yuanqing Chao, Cui-Ping Li, Tzu-Yuan Chao, Wu-Chou Su, Ruey-Kuen Hsieh, Ming-Fang Wu, Kun-Huei Yeh, Woei-Yau Kao, Li-Tzong Chen, Ann-Lii Cheng. An open, multi-centre, phase II clinical trial to evaluate the efficacy and safety of paclitaxel, UFT, and leucovorin in patients with advanced gastric cancer. British Journal of Cancer 2006 Jul; 95(2):159-163.
  171. Hsuan-Heng Yeh, Wu-Wei Lai, Helen H.W. Chen, Hsiao-Sheng Liu, Wu-Chou Su*. Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion. Oncogene 2006 Jul; 25(31):4300-4309.
  172. Chih-Chia Huang, Jih Ru Hwu, Wu-Chou Su, Dar-Bin Shieh, Yonhua Tzeng, Chen-Sheng Yeh. Surfactant-assisted hollowing of Cu nanoparticles involving halide-induced corrosion-oxidation processes. Chemistry-A European Journal 2006 May; 12(14):3805-3810.
  173. Helen H.W. Chen, Wu-Chou Su, Cheng-Yang Chou, How-Ran Guo, Sheng-Yow Ho, Jenny Que, Wen-Ying Lee. Increased expression of nitric oxide synthase and cyclooxygenase-2 is associated with poor survival in cervical cancer treated with radiotherapy. International Journal of Radiation Oncology Biology Physics 2005 Nov; 63(4):1093-1100.
  174. Yu-Chang Tyan, Hsin-Yi Wu, Wu-Wei Lai, Wu-Chou Su, Pao-Chi Liao. Proteomic profiling of human pleural effusion using two-dimensional nano liquid chromatography tandem mass spectrometry. Journal of Proteome Research 2005 Jul; 4(4):1274-1286.
  175. Tsai-Yun Chen, Jiann-Shiuh Chen, Wu-Chou Su, Ming-Shiuan Wu, Chao-Jung Tsao. Expression of DNA repair gene Ku80 in lymphoid neoplasm. European Journal of Haematology 2005 Jun; 74(6):481-488.
  176. Wen-Ying Lee, Helen H.W. Chen, Nan-Haw Chow, Wu-Chou Su, Pin-Wen Lin, How-Ran Guo. Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients. Clinicaal Cancer Research 2005 Mar; 11(6):2222-2228.
  177. Yu-Chang Tyan, Hsin-Yi Wu, Wu-Chou Su, Pang-Wei Chen, Pao-Chi Liao. Proteomic analysis of human pleural effusion. Proteomics 2005 Mar; 5(4): 1062-1074.
  178. Wen-Ying Lee, Wu-Chou Su, Pin-Wen Lin, How-Ran Guo, Tsai-Wang Chang, Helen H.W. Chen. Expression of S100A4 and Met: potential predictors for metastasis and survival in early-stage breast cancer. Oncology 2004 Sep; 66(6): 429-438.
  179. Shiang-Jiin Leaw, Chia-Jui Yen, Wen-Tsung Huang, Tsai-Yun Chen, Wu-Chou Su, Chao-Jung Tsao. Preemptive use of interferon or lamivudine for hepatitis B reactivation in patients with aggressive lymphoma receiving chemotherapy. Annals of Hematology 2004 May; 83(5):270-275.
  180. Yen-Chien Lee, Kung-Chia Young, Wu-Chou Su, Chao-Jung Tsao, Tsai-Yun Chen. Emergence of YMDD mutant hepatitis B virus after allogeneic stem cell transplantation from a HBsAG-positive donor during lamivudine prophylaxis. Haematologica-The Hematology Journal 2004 Apr; 89(3):e30-e31.
  181. Wen-Tsung Huang, Tsai-Yun Chen, Wu-Chou Su, Chia-Jui Yen, Chao-Jung Tsao. Implantable venous port-related infections in cancer patients. Supportive Care in Cancer 2004 Mar; 12(3):197-201.
  182. Yin-Hsun Feng, Chia-Jui Yen, Wen-Tsung Huang, Wu-Chou Su, Tsai-Yun Chen, Chao-Jung Tsao. Clinical response of antilymphocyte globulin-based treatment in patients in taiwan with aplastic anemia: positive hepatitis C antibody may represent a response predictor. International Journal of Hematology 2004 Feb; 79(2):133-137.
  183. Helen H. W. Chen, Wu-Chou Su, How-Ran Guo, Bi-Fang Lee, Wei-Ren Su, Pei-Shan Wu, Nan-Tsing Chiu. Clinical significance and outcome of one or two rib lesions on bone scans in breast cancer patients without known metastases. Nuclear Medicine Communications 2003 Nov; 24(11):1167-1174.
  184. Tsui-Lien Hung, Fen-Fen Chen, Jacqueline M. Liu, Wu-Wei Lai, Ai-Li Hsiao, Wen-Tsung Huang, Helen H.W. Chen, Wu-Chou Su*. Clinical evaluation of HER-2/neu protein in malignant pleural effusion-associated lung adenocarcinoma and as a tumor marker in pleural effusion diagnosis. Clinical Cancer Research 2003 Jul; 9(7):2605-2612.
  185. Tasi-Yun Chen, Jen-Shi Chen, Wen-Tsung Huang, Wu-Chou Su, Chao-Jung Tsao. Rapid engraftment of mast cells of donor origin in a case of acute myeloid leukemia with mast cell leukemia after allogeneic stem cell transplantation. Bone Marrow Transplantation 2003 Jul; 32(1):111-114.
  186. Jenn-Ren Hsiao, Ying-Tai Jin, Sen-Tien Tsai, Ai-Li Shiau, Chao-Liang Wu, Wu-Chou Su*. Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis. British Journal of Cancer 2003 Jul; 89(2):344-349.
  187. Tsai-Yun Chen, Helen H. W. Chen, Wu-Chou Su, Chao-Jung Tsao. High-dose chemotherapy and hematopoietic stem cell transplantation for patients with nasopharyngeal cancer: a feasibility study. Japanese Journal of Clinical Oncology 2003 Jul; 33(7):331-335.
  188. Ming-Hsien Lin, Jeng-Jong Huang, Tsai-Yun Chen, Fen-Fen Chen, Kong-Chao Chang, Ming-Fei Liu, Wen-Tsung Huang, Wu-Chou Su, Chao-Jung Tsao. EBER-1 positive diffuse large cell lymphoma presenting as lupus nephritis. Lupus 2003 Jun; 12(6):486-489.
  189. Ming-Hsien Lin, Jen-Shi Chen, Helen H.W. Chen, Wu-Chou Su*. A phase II trial of gemcitabine in the treatment of advanced bile duct and periampullary carcinomas. Chemotherapy 2003 Jun; 49(3):154-158.
  190. Tsai-Yun Chen, Wu-Chou Su, Chao-Jung Tsao. Incidence of thrombophilia detected in southern Taiwanese patients with venous thrombosis. Annals of Hematology 2003 Feb; 82(2):114-117.
  191. Wu-Chou Su*, Wu-Wei Lai, Helen H.W. Chen, Tzuen-Ren Hsiue, Cheng-Wen Chen, Wen-Tsung Huang, Tsai-Yun Chen, Chao-Jung Tsao, Nai-San Wang. Combined intrapleural and intravenous chemotherapy, and pulmonary irradiation, for treatment of patients with lung cancer presenting with malignant pleural effusion. A pilot study. Oncology 2003 Jan; 64(1):18-24.
  192. Chao-Neng Cheng, Cheng-Chan Lu, Hsiao-Fang Sunny Sun, Wu-Chou Su, Jiann-Shiuh Chen. Successful matched-unrelated bone marrow transplantation in a patient with beta-thalassemia major. Journal of Pediatric Hematology Oncology 2002 Oct; 24(7):579-581.
  193. Helen H.W. Chen, Wu-Chou Su, How-Ran Guo, Tsai-Wang Chang, Wen-Ying Lee. p53 and c-erbB-2 but not bcl-2 are predictive of metastasis-free survival in breast cancer patients receiving post-mastectomy adjuvant radiotherapy in Taiwan. Japanese Journal of Clinical Oncology 2002 Sep; 32(9):332-339.
  194. Wu-Wei Lai, Fen-Fen Chen, Ming-Ho Wu, Nan-Haw Chow, Wu-Chou Su, Mi-Chia Ma, Pei-Fang Su, Helen Chen, Mu-Yen Lin, Yau-Lin Tseng. Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer. Annals of Thoracic Surgery 2001 Dec; 72(6):1868-1876.
  195. Wu-Chou Su*, Shu-Chu Shiesh, Hsiao-Sheng Liu, Chiung-Yu Chen, Nan-Haw Chow, Xi-Zhang Lin. Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders. Digestive Diseases and Sciences 2001 Jul; 46(7):1387-1392.
  196. Wu-Chou Su*, Shu-Ling Chang, Tsai-Yun Chen, Jiann-Shiuh Chen, Chao-Jung Tsao. Comparison of in vitro growth-inhibitory activity of carboplatin and cisplatin on leukemic cells and hematopoietic progenitors: the myelosuppressive activity of carboplatin may be greater than its antileukemic effect. Japanese Journal of Clinical Oncology 2000 Dec; 30(12):562-567.
  197. Tsai-Yun Chen, Sen-Tien Tsai, Ying-Tai Jin, Wu-Chou Su, Chao-Jung Tsao. Bone marrow metastasis in nasopharyngeal cancer: early detection using EBER1 in situ hybridization. Anticancer Research 1999 Jan; 19(1B):885-888.
  198. Wu-Chou Su, Nan-Haw Chow, Chia-Huy Huang, Hsiao-Sheng Liu. Using 2-step PCR and restriction endonuclease digestion to detect K-ras mutation in paraffin-embedded tissues: is it reliable? Journal of Clinical Laboratory Analysis 1998 Dec; 12(3):168-171.
  199. Nan-Haw Chow, Kuo-Sheng Cheng, Pin-Wen Lin, Shih-Huang Chan, Wu-Chou Su, Yung-Nien Sun, Xi-Zhang Lin. Expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and hepatocellular carcinoma. Digestive Diseases and Sciences 1998 Oct; 43(10):2261-2266.
  200. Jiann-Shiuh Chen, Ching-Cherng Tzeng, Chao-Jung Tsao, Wu-Chou Su, Tsai-Yun Chen, Yun-Chih Jung, Ih-Jen Su. Clonal karyotype abnormalities in EBV-associated hemophagocytic syndrome. Haematologica-The Hematology Journal 1997 Sep; 82(5):572-576.
  201. Wu-Chou Su, Motoo Kitagawa, Ninrong Xue, Bing Xie, Silvio Garofalo, Jay Cho, Chuxia Deng, William A. Horton, Xin-Yuan Fu. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature 1997 Mar; 386(6622):288-292.
  202. Wu-Chou Su*, Kuo-Kuan Chan, Xi-Zhang Lin, Pin-Wen Lin, Nan-Haw Chow, Jeng-Shiann Shin, Chiung-Yu Chen, Chao-Jung Tsao. A clinical study of 130 patients with biliary tract cancers and periampullary tumors. Oncology 1996 Nov; 53(6):488-493.
  203. Chiung-Yu Chen, Shu-Chu Shiesh, Wu-Chou Su, Kuo-Kuan Chang, Xi-Zhang Lin. Sequential changes of bile contents in patients with obstructive jaundice from different etiologies. Hepato-gastroenterology 1996 Jul; 43(10):796-799.
  204. Yue E. Chin, Motoo Kitagawa, Wu-Chou Su, Zhi-Hao You, Yoshiki Iwamoto, Xin-Yuan Fu. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 1996 May; 272(5262): 719-722.
  205. Nan-Haw Chow, Shih-Ming Huang, Shih-Huang Chan, Lein-Raymo Mo, Min-Huo Hwang, Wu-Chou Su*. Significance of c-erbB-2 expression in normal and neoplastic epithelium of biliary tract. Anticancer Research 1995 May; 15(3):1055-1059.

 

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