跳到主要內容區塊
:::

張定宗 Ting-Tsung Chang

Ting-TsungChang

張定宗  內科學科  特聘教授  (Ting-Tsung Chang)

E-mail:ttchang@mail.ncku.edu.tw

電話:06-2353535 分機5389

傳真:06-2095233

 

學經歷

 

學歷
1975/09~1982/06

台北醫學院,醫學士

   

 

現職 2006/08~ 國立成功大學醫學院內科學科,特聘教授
 
 
經歷 2013/12~迄今 國立成功大學研究總中心肝臟醫學生物科技研究中心主任
  2013/08~迄今 國立成功大學醫學院內科部副主任
  2000/08~2004/07 國立成功大學醫學院分子醫學研究所所長
  2000/08~2004/07 國立成功大學醫學院附設醫院內科部胃腸肝膽科主任
  2000/08~2002/07 國立成功大學醫學院附設醫院臨醫部主任
  2000/08~2002/07 國立成功大學醫學院臨床醫學研究所所長
  1998/08~2000/07 國立成功大學醫學院附設醫院醫務秘書
  2006/08~迄今 國立成功大學醫學院內科學科,特聘教授
  1996/08~2006/07 國立成功大學醫學院內科學科,教授
  1993/08~1996/07 國立成功大學醫學院內科學科, 副教授, 專任
  1990/08~1993/07 國立成功大學醫學院內科學科, 講師, 專任
  1989/08~迄今 國立成功大學醫學院附設醫院內科部,主治醫師
  1989/08~1990/07 國立成功大學醫學院附設醫院內科部, 主治醫師, 專任
  1988/07~1989/07 台北榮民總醫院, 總醫師, 專任

 

1984/11~1988/06 台北榮民總醫院, 住院醫師, 專任

 

專長/研究興趣

 

內科、腸胃肝膽科、肝炎、病毒學
   

 

研究興趣:

B型及C型肝炎病毒侵入人體機制、疾病進展或治療療效的相關研究,宿主及病毒扮演著不同的重要角色。我們的實驗室即針對病毒及宿主的基因特性和免疫相互作用,進行臨床醫學與基礎醫學整合性研究。我們的研究包含:

1.利用高通量定序方法(NGS)探討B型肝炎病毒感染造成的肝癌病患以及用藥前後的慢性B型肝炎患者血清中以及肝組織中B型肝炎病毒的多變異株序列表現差異:
本研究利用聚合?連鎖反應配合高通量定序方法分析HBV基因體序列多型性,已成功建立分析平台並發現新的病毒致癌準株種。本研究已於細胞模式探討致癌準株種參與肝癌形成的部分機制以及病毒的突變、演化及演進,並研發檢測病毒致癌準株種之相關技術,此部分已提出專利申請。


2.探討次世代高通量定序所發現之與肝癌相關病毒準株種(NGS defined HCC-associated HBV variants)參與調控DNA修復系統及病毒嵌入於肝癌發展之機轉: 
此研究之目標: (一)探討B型肝炎病毒蛋白如何參與DNA修復反應,從而釐清B型肝炎病毒蛋白參與DNA修復過程的新機制;(二)探討在B型肝炎病毒感染病患的肝臟組織及血球細胞中,特殊DNA修復機制以及B型肝炎病毒蛋白如何造成基因體不穩定現象。


3.探討用藥過程中和停藥後,血清中B型肝炎病毒表面蛋白抗原、B型肝炎病毒前基因體RNA(pregenomic RNA)、B型肝炎病毒DNA之相互動態,以利於作為藥物治療療效、病患是否痊癒及病患是否復發的指標:
此研究已發現血清中B型肝炎病毒表面蛋白抗原的量可以預測病患痊癒,對於E抗原陽性之病患其表面蛋白抗原< 4(log IU/mL)可預測病患用藥後可達到virological, serological, and biochemical outcomes;對於E抗原陰性之病患其表面蛋白抗原< 2.4(log IU/mL)可預測病患用藥後可達到virological, serological, and biochemical outcomes。此研究也發現前基因體RNA(pregenomic RNA)可作為病毒清除的標的。


4.腸道菌對於肝炎病毒免疫感受性以及代謝產物之影響 
此研究將利用次世代定序分析方法探討不同慢性肝炎病患糞便中腸道菌的菌像,並分析其代謝物圖譜及免疫圖譜。建立台灣人種腸道菌像分布資料庫以及探討免疫感受性以及代謝產物對疾病的影響。

 

執行中研究計畫

1.      探討病患肝組織、糞便及口腔之微生物菌相及其相關因子在肝細胞癌和膽道癌中所扮演的角色並探尋術後復發之生物標的

2.      探討新發現的B型肝炎病毒表面抗原變異株經由DNA損傷反應導致肝癌的致病機制及臨床抗癌藥物之應用

3.     慢性B型肝炎病人接受抗病毒藥物治療中及停止後臨床預後與生物指標的關係

   

 

 

 

研究成果(Publications) -- Ting-Tsung Chang

 
  1. Liu WC, Wu IC, Chiu YC, Tseng KC, Chen CY, Chiu HC, Cheng PN, Chang TT. Genotyping of immune-related loci associated with delayed HBeAg seroconversion in immune-active chronic hepatitis B patients. Antiviral Res. 2020 Jan 28:104719
  2. Ho CH, Chang TT, Chien RN. Telbivudine on IgG-associated Hypergammaglobulinemia and TGF-β1 Hyperactivity in Hepatitis B Virus-related Liver Cirrhosis. PLoS One. 2019 Nov 26;14(11):e0225482
  3. Lin TC, Liu WC, Hsu YH, Lin JJ, Chiu YC, Chiu HC, Cheng PN, Chen CY, Chang TT, Wu IC. Insulin Resistance Associated Disorders Pivoting Long-Term Hepatitis B Surface Antigen Decline during Entecavir Therapy. J Clin Med. 2019 Nov 6;8(11). pii: E1892
  4. Chang TT, Cheng JH, Tsai HW, Young KC, Hsieh SY, Ho CH. Plasma proteome plus site-specific N-glycoprofiling for hepatobiliary carcinomas. J Pathol Clin Res. 2019 Jul;5(3):199-212.
  5. Lee YC, Hsieh CC, Chang TT, Li CY. Contrast-Induced Acute Kidney Injury Among Patients With Chronic Kidney Disease Undergoing Imaging Studies: A Meta-Analysis. AJR Am J Roentgenol. 2019 Oct;213(4):728-735
  6. Ho CH, Chen SH, Tsai HW, Wu IC, Chang TT. Fully galactosyl-fucosyl-bisected IgG1 reduces anti-HBV efficacy and liver histological improvement. Antiviral Res. 2019 Jan 3;163:1-10.
  7. Chang TT, Tsai HW, Ho CH. Fucosyl-Agalactosyl IgG1 Induces Cholangiocarcinoma Metastasis and Early Recurrence by Activating Tumor-Associated Macrophage. Cancers 2018, 10(11), 460
  8. Wu IC, Liu WC, Chang TT. Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations. J Biomed Sci. 2018 Jun 2;25(1):51. (correspondence)
  9. Puoti M, Foster GR, Wang S, Mutimer D, Gane E, Moreno C, CHANG TT, Lee SS, Marinho R, DuFour JF, Pol S, Hezode C, Gordon SC, Strasser SI, Thuluvath PJ, Zhang Z, Lovell S, Pilot-Matias T, Mensa FJ. High SVR12 with 8-week and 12-week Glecaprevir/Pibrentasvir: Integrated Analysis of HCV Genotype 1-6 Patients Without Cirrhosis. J Hepatol. 2018 Mar 15. pii: S0168-8278(18)30165-X. [Epub ahead of print]
  10. Tsai HW, Ho CL, Cheng SW, Lin YJ, Chen CC, Cheng PN, Yen CJ, CHANG TT, Chiang PM, Chan SH, Ho CH, Chen SH, Wang YW, Chow NH, Lin JC. Progesterone receptor membrane component 1 as a potential prognostic biomarker for hepatocellular carcinoma. World J Gastroenterol 2018; 24(10): 1152-1166
  11. LIU WC, LIN CP, CHENG CP, HO CH, LAN KL, CHENG JH, YEN CJ, CHENG PN, WU IC, LI IC, CHANG Bill CH, TSENG VS, CHIU YC, CHANG TT. Aligning to the Sample-Specific Reference Sequence to Optimize the Accuracy of Next-Generation Sequencing Analysis for Hepatitis B Virus. Hepatology International. 2016 Jan;10(1):147-57 (correspondence)
  12. Chan HL, Ahn SH, CHANG TT, Peng CY, Wong D, Coffin CS, Lim SG, Chen PJ, Janssen H, Marcellin P, Serfaty L, Zeuzem S, Cohen D, Critelli L, Xu D13 Wind-Rotolo M, Cooney E; LIRA-B Study Team. Peginterferon Lambda for the Treatment of HBeAg-Positive Chronic Hepatitis B: A Randomized Phase 2b Study (LIRA-B). Journal of Hepatology. 2015 Dec 29. pii: S0168-8278(15)00859-4.
  13. LIN HH, LEE SS, YU ML, CHANG TT, SU CW, HU BS, CHEN YS, HUANG CK, LAI CH, LIN JN, WU JC. Changing hepatitis D virus epidemiology in a hepatitis B virus endemic area with a national vaccination program. Hepatology. 2015 Jun; 61(6):1870-9.
  14. JAIN S, CHANG TT, CHEN S, BOLDBAATAR B, CLEMENS A, LIN SY, YAN R, HU CT, GUO H, BLOCK TM, SONG W, SU YH. Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues. Sci Rep. 2015 May 22; 5:10478.
  15. BOWDEN S, LOCAMINI S, CHANG TT, CHAO YC, HAN KH, GISH RG, DE MAN RA, YU M, LLAMOSO C, TANG H. Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine. World J Gastroenterol. 2015 Apr 21; 21(15):4644-51.
  16. HO CH, CHIEN RN, CHENG PN, LIU JH, LIU CK, SU CS, WU IC, LI IC, TSAI HW, WU SL, LIU WC, CHEN SH, CHANG TT. Aberrant Serum IgG Glycosylation in Chronic Hepatitis B is Associated with Histological Liver Damage and is Reversible by Antiviral Therapy. J Infect Dis. 2015 Jan 1;211(1):115-24. (correspondence)
  17. HO CH, CHIEN RN, CHENG PN, LIU CK, SU CS, WU IC, LIU WC, CHEN SH, CHANG TT. Association of Serum IgG N-glycome and Transforming Growth Factor-β1 With Hepatitis B virus e Antigen Seroconversion During Entecavir Therapy. Antiviral Research. 2014 Nov;111:121-8. (correspondence)
  18. CHENG PN, CHIU YC, TSAI HW, WANG RH, CHIU HC, WU IC, CHANG TT. HBsAg Expression of Liver Correlates with Histological Activities and Viral Replication in Chronic Hepatitis B. Annals of Hepatology. 2014 Nov-Dec;13(6):771-80 (correspondence)
  19. LIN CC, TSAI PJ, SUN HY, HSU MC, LEE JC, WU IC, TSAO CW, CHANG TT, YOUNG KC. Apolipoprotein J, a glucose up-regulated molecular chaperone stabilizes core and NS5A to promote infectious hepatitis C virus virion production.2014 Nov. Journal of Hepatology. 61(5):984-93.
  20. Michael Manns, Stanislas Pol, Ira M. Jacobson, Patrick Marcellin, Stuart C. Gordon, Cheng-Yuan Peng, Ting-Tsung Chang, Gregory T. Everson, Jeong Heo, Guido Gerken, Boris Yoffe, William J. Towner, Marc Bourliere, Sophie Metivier, Chi-Jen Chu, William Sievert, Jean-Pierre Bronowicki, Dominique Thabut, Youn-Jae Lee, Jia-Horng Kao, Fiona McPhee, Justin Kopit, Patricia Mendez, Misti Linaberry, Eric Hughes, and Stephanie Noviello, on behalf of the HALLMARK-DUAL Study Team. All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study. 2014 Nov. The Lancet. 384(9954):1597-605
  21. TSENG CW, CHEN CY, CHANG TT, TZENG SJ, HSIEH YH, HUNG TH, LEE CC, WU SF, TSENG KC. Peginterferon Alfa-2a is Associated with Elevations in Alanine Aminotransferase at the End of Treatment in Chronic Hepatitis C Patients with Sustained Virologic Response. PLoS One. 2014 Jun; 9 (6): e100207
  22. CHAN HL, CHAN CK, HUI AJ, CHAN S, POORDAD F, CHANG TT, MATHURIN P, FLAHERTY JF, LIN L, CORSA A, GAGGAR A, SUBRAMANIAN GM, MCHUTCHISON JG, LEE S, GANE EJ. Effects of Tenofovir Disoproxil Fumarate in Hepatitis B e Antigen-Positive Patients With Normal Levels of Alanine Aminotransferase and High Levels of Hepatitis B Virus DNA. Gastroenterology. 2014 May;146(5):1240-8.
  23. TSENG KC, CHEN CY, TSAI HW, CHANG TT, CHUANG WL, HSU PI, LIU WC, CHENG PN. Efficacy of entecavir in chronic hepatitis B patients with persistently normal alanine aminotransferase: randomized, double-blind, placebo-controlled study. Antivir Ther. 2014 Feb; 19(8):755-64
  24. CHENG SW, TSAI HW, LIN YJ, CHENG PN, CHANG YC, YEN CJ, HUANG HP, CHUANG YP, CHANG TT, LEE CT, CHAO A, CHOU CY, CHAN SH, CHOW NH, HO CL. Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma. PLoS One. 2013 Nov 14;8(11):e80053.
  25. CHENG PN, TSAI HW, CHIU YC, HO CH, WU IC, CHANG TT. Clinical Significance of Serum HBsAg Levels and Association with Liver Histology in HBeAg Positive Chronic Hepatitis B. J Clin Virol. 2013 Aug;57(4):323-30. (correspondence)
  26. SUN HY, LIN CC, LEE JC, WANG SW, CHENG PN, WU IC, CHANG TT, LAI MD, SHIEH DB, YOUNG KC. 2013 Aug. Very-low density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III. Gut. 62(8):1193–1203.
  27. TSENG KC, TSENG CW, HSIEH YH, CHANG CK, LAI NS, HUNG TH, CHANG TT. Effect of Human Leukocyte Antigen Class I and II alleles on Hepatitis C viral load among Chronic Hepatitis C Patients in Southern Taiwan. Hum Immunol. 2013 Aug; 74 (8):978-82. (correspondence)
  28. GISH RG, CHANG TT, LAI CL, DE MAN RA, GADANO A, LLAMOSO C, TANG H. Quantitative hepatitis B surface antigen analysis in hepatitis B e antigen-positive, nucleoside-naive patients treated with entecavir. Antivir Ther. 2013. Mar; 18(5):691-698.
  29. TONG MJ, KOWDLEY KV, PAN C, HU KQ, CHANG TT, HAN KH, YOON SK, GOODMAN ZD, BEEBE S, ILOEJE U, TANG H. 2013. Apr. Improvement in liver histology among asian patients with chronic hepatitis B after long-term treatment with entecavir. Liver international. 33(4):650-651.
  30. HSU CW, CHAO YC, LEE CM, CHANG TT, Chen YC. 2012. Dec. Efficacy of telbivudine in Taiwanese chronic hepatitis B patients compared with GLOBE extension study and predicting treatment outcome by HBV DNA kinetics at Week 24. BMC Gastroenterol. 13;12:178.
  31. WANG CS, CHANG TT, YAO WJ, WANG ST, CHOU P. 2012. Apr. Impact of increasing alanine aminotransferase levels within normal range on incident diabetes. J Formos Med Assoc. 2012 ;111(4):201-8.
  32. YEN CJ, LIN YJ, YEN CS, TSAI HW, TSAI TF, CHANG KY, HUANG WC, LIN PW, CHIANG CW, CHANG TT. 2012 Jul. Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKK beta to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma. PLoS ONE. 7(7): e41931 (correspondence)
  33. Surbhi Jain, Sitong Chen, Kung-Chao Chang, Yih-Jyh Lin., Chi-Tan Hu., Batbold Boldbaatar,James P. Hamilton, Selena Y. Lin, Ting-Tsung Chang, Shun-Hua Chen, Wei Song,Stephen J. Meltzer, Timothy M. Block, Ying-Hsiu Su.2012. Impact of the Location of CpG Methylation within the GSTP1 Gene on Its Specificity as a DNA Marker for Hepatocellular Carcinoma. PLoS One. April 2012 | Volume 7 | Issue 4 | e35789
  34. Hung-Yu Sun, Chun-Chieh Lin, Jin-Ching Lee, Shainn-Wei Wang, Pin-Nan Cheng, I-Chin Wu, Ting-Tsung Chang , Ming-Derg Lai , Dar-Bin Shieh , Kung-Chia Young. Very-low density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III. Gut.2012 Jun 11. [Epub ahead of print]
  35. Calvin Q. Pan, Myron Tong, Kris V. Kowdley, Ke-Qin Hu, Ting-Tsung Chang, Ching-Lung Lai, Seung Kew Yoon, Samuel S. Lee, David Cohen, Hong Tang, Naoky Tsai. High Rates of Viral Suppression After Long-Term Entecavir Treatment of Asian Patients With Hepatitis B e Antigen–Positive Chronic Hepatitis B. Clin Gastroenterol Hepatol. 2012 Apr 1. [Epub ahead of print]
  36. Chun-Pei Cheng, Pei-Fen Lee, Wen-Chun Liu, I-Chin Wu, Chu-Yu Chin, Ting-Tsung Chang, Vincent S. Tseng. Analysis of Precore/core Covariances Associated with Viral Kinetics and Genotypes in Hepatitis B e Antigen-positive Chronic Hepatitis B Patients. 2012.PLoS One. 2012;7(2):e32553
  37. Michael P Manns, Ulus S Akarca, Ting-Tsung Chang, William Sievert, Seung Kew Yoon, Naoky Tsai, Albert Min, Andreas Pangerl, Suzanne Beebe, Miao Yu & Suchat Wongcharatrawee. (2012) Long-term safety and tolerability of entecavir in patients with chronic hepatitis B in the rollover study ETV-901. Expert Opin Drug Saf. 2012 May;11(3):361-8. Epub 2012 Jan 11.
  38. Surbhi Jain, Ting-Tsung Chang, James P. Hamilton, Selena Y. Lin, Yih-Jyh Lin, Alison A. Evans, Florin M. Selaru, Pin- Wen Lin, Shun-Hua Chen, Timothy M. Block, Chi-Tan Hu,Wei Song, Stephen J. Meltzer, Ying-Hsiu Su. (2011) Methylation of the CpG Sites Only on the Sense Strand of the APC Gene Is Specific for Hepatocellular Carcinoma. PLoS One. 2011;6(11):e26799.
  39. Hung-Yu Sun, Nai-Ying Ou, Shainn-Wei Wang, Wen-Chun Liu, Ting-Fang Cheng, Shiou-Jiuan Shr, Koun-Tem Sun, Ting-Tsung Chang, Kung-Chia Young.(2011) Novel Nucleotide and Amino Acid Covariation between the 5’UTR and the NS2/NS3 proteins of Hepatitis C Virus: Bioinformatic and Functional Analyses. PLoS ONE 2011;6(9):e25530. Epub 2011 Sep 28.
  40. Selena Y. Lin, Veerpal Dhillon, Surbhi Jain, Ting-Tsung Chang, Chi-Tan Hu, Yih-Jyh Lin, Shun-Hua Chen, Kung-Chao Chang, Wei Song, Lixin Yu, Timothy M. Block, and Ying-Hsiu Su. (2011) A Locked Nucleic Acid Clamp-Mediated PCR Assay for Detection of a p53 Codon 249 Hotspot Mutation in Urine. Journal of Molecular Diagnostics 13:474-484
  41. Jun-Wei Lee, Pao-Chi Liao, Kung-Chia Young, Christina L. Chang, Steve S. L. Chen, Ting-Tsung Chang, Ming-Derg Lai, and Shainn-Wei Wang (2011) Identification of hnRNPH1, NF45, and C14orf166 as Novel Host Interacting Partners of the Mature Hepatitis C Virus Core Protein. J Proteome Res. 2011 Oct 7;10(10):4522-34.
  42. CHENG PN, LIU WC, TSAI HW, WU IC, CHANG TT, YOUNG KC. 2011 Apr. Association of Intrahepatic cccDNA reduction with the improvement of liver histology in chronic hepatitis B patients receiving oral antiviral agents. Journal of Medical Virology, 83(4):602-607.
  43. Wang CS, Chang TT, Yao WJ, Wang ST, Chou P. 2010. Apr. The impact of smoking on incident type 2 diabetes in a cohort with hepatitis B but not hepatitis C infection. J Viral Hepat. J Viral Hepat. 2010 Aug 31. [Epub ahead of print]
  44. Liaw YF, Sheen IS, Lee CM, Akarca US, Papatheodoridis GV, Wong FH, CHANG TT, HORBAN A, WANG C, KWAN P, PRIETO M, BERG T, KITRINOS K, PESCHELL K, MONDOU E, FREDERICK D, ROUSSEAU F and SCHIFF ER. 2011 Jan. Tenofovir Disoproxil Fumarate (TDF), Emtricitabine/TDF and Entecavir in Patients with Decompensated Chronic Hepatitis B Liver Disease. Hepatology (in press).
  45. SUN KT, WEI CH, HSU YY, LIU WC, CHANG TT. 2010 July. On Deriving an Equation of the Mutation Rate of the Hepatitis B Virus. Journal of Convergence Information Technology, 5(5)131-137.
  46. WU IC, LAI CL, HAN SH, HAN KH, GORDON SC, YC CHAO YC, TAN CK, SIEVERT W, TANWANDEE T, NEO BL, CHANGTT. 2010. Apr Efficacy of Entecavir in Chronic Hepatitis B Patients with Mildly Elevated Alanine Aminotransferase and Biopsy-Proven Histologic Damage. Hepatology. 51(4) 1185-1189. (correspondence)
  47. Chang TT, Yun-Fan Liaw, Shun-Sheng Wu, Eugene Schiff, Kwang-Hyub Han, Ching-Lung Lai, Rifaat Safadi, Samuel S Lee, Waldemar Halota, Zachary Goodman, Yun-Chan Chi  Hui Zhang, Robert Hindes, Uchenna Iloeje, Suzanne Beebe, Bruce Kreter. 2010. Sep Long-term entecavir therapy results in reversal of fibrosis/cirrhosis and continued histologic improvement in chronic hepatitis B patients. Hepatology. 52(3) 886-893.(correspondence)
  48. CHANG TT, LAI CL, YOON SK, LEE SS, COEHLO HSM, CARRILHO FJ, POORDAD F, HALOTA W, HORSMANS Y, TSAI N, ZHANG H, TENNEY DJ, TAMEZ R, ILOEJE U 2010. Feb Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B. Hepatology. 51(2) 422-430. (correspondence)
  49. TSENG KC, CHEN LH, CHEN CY, CHANG TT, CHOU AL, WU IC, CHENG PN. 2009 Low Dose of Erythropoietin-beta Improves Anemia and Maintains Ribavirin Dose in Chronic hepatitis C patients receiving Combination Therapy with Ribavirin plus Pegylated Interferon Alfa-2b" Hepatology Research.39(6):539-45.
  50. GISH R, CHANG TT, LAI CL, MAN R, GADANO A, POORDAD F, YANG J, TAMEZ R, BRETT-SMITH H. 2009 Mar Loss of HBsAg Antigen During Treatment With Entecavir in Nucleoside-naïve HBeAg-positive Patients With Chronic Hepatitis B. Journal of Viral Hepatitis.17,16-22
  51. CHANG TT. 2009 On-treatment monitoring of HBV DNA levels: predicting response and resistance to oral antiviral therapy at week 24 versus week 48. Hepatology International 3:S16–S23. (REVIEW) (correspondence)
  52. CHANG TT, CHAO YC, GORBAKOV VV, HAN KH, GISH RG, MAN R, CHEINQUER H, BESSONE F, BRETT-SMITH H, TAMEZ R. 2009 Nov. Results of Up To 2 Years of Entecavir Versus Lamivudine Therapy in Nucleoside-Naive HBeAg-positive Patients With Chronic Hepatitis B. Journal of Viral Hepatitis 16:784–789. (correspondence)
  53. Wang CS. Yao WJ. Chang TT. Wang ST. Chou P. 2009 Jul. The impact of type 2 diabetes on the development of hepatocellular carcinoma in different viral hepatitis statuses. Cancer Epidemiology, Biomarkers & Prevention. 18(7):2054-60
  54. TSENG KC, CHENG PN, WU IC, CHANG CK, CHOU AL, LIU WC, CHANG TT. 2009 May.-Jun. HBV DNA Level as an Important Determinant of E Antigen Seroconversion of Chronic Hepatitis B during Adefovir Dipivoxil Therapy. Hepato-Gastroenterology 56(91-92):813-818. (correspondence)
  55. WU CJ, LEE HC, CHANG TT, CHEN CY, LEE NY, CHANG CM, SHEU BS, CHENG PN, SHIH HI, KO WC. 2009 Apr. Aeromonas spontaneous bacterial peritonitis: a highly fatal infectious disease in patients with advanced liver cirrhosis. Journal of the Formosan Medical Association. 108(4):293-300.
  56. SHOUVAL D, LAI CL, CHANG TT, CHEINQUER H, MARTIN P, CAROSI G, HAN S, KAYMAKOGLU S, TAMEZ R, YANG J, TENNEY D, BRETT-SMITH H. 2009 Feb. Relapse of hepatitis B in HBeAg-negative chronic hepatitis B patients who discontinued successful entecavir treatment: the case for continuous antiviral therapy. Journal of Hepatology. 50(2):289-95.
  57. WU IC, SHIFFMAN ML, TONG M, MARCELLIN P, MONDOU E, FREDERICK D, SNOW-LAMPART A, SORBEL J, ROUSSEAU F, CHANG TT. 2008 Nov. Sustained HBeAg Seroconversion among Chronic Hepatitis B Patients after Adefovir Dipivoxil Treatment - Analysis of Precore/Basal Core Promoter Mutants. Clinical Infectious Diseases 45:1305-1311 (correspondence)
  58. CHENG PN, CHANG TT. 2008 Oct. Entecavir: A potent antiviral with minimal long-term resistance in nucleoside-naive chronic hepatitis B patients. Expert Review of Anti-infective Therapy 6(5):569-579 (correspondence).
  59. LIU WC, LINDH M, BUTI M, PHIET PH, MIZOKAMI M, LI HH, SUN KT, YOUNG KC, CHENG PN, WU IC, CHANG TT. 2008 Sep. Genotyping of hepatitis B virus genotype A - G by multiplex-PCR. Intervirology 51:247-252. (correspondence)
  60. MARCELLIN P, CHANG TT, LIM SG, SIEVERT W, TONG M, ARTERBURN S, BORROTO-ESODA K, FREDERICK D, ROUSSEAU F. 2008 Sep. Long-term efficacy and safety of Adefovir Dipivoxil for the treatment of hepatitis B e antigen–positive chronic hepatitis B. Hepatology 48(3):750-758.
  61. CHENG PN, WEI YL, CHANG TT, CHEN JS, YOUNG KC. 2008 Jun. Therapy with interferon-a and ribavirin for chronic hepatitis C virus infection upregulates membrane HLA-ABC, CD86, and CD28 on peripheral blood mononuclear cells. J Med Virol 80(6):989–996.
  62. CHANG TT, Suh DJ. 2008 May Current approaches for treating chronic hepatitis B: when to start, what to start with, and when to stop. Hepatology International 2:S19-27 (correspondence).
  63. LIM SG, MARCELLIN P, TASSOPOULOS N, HADZIYANNIS S, CHANG TT, TONG M, SIEVERT W, HU P, ARTERBURN S, BROSGART CL. 2007 Nov. Effects of Adefovir Dipivoxil Therapy in Asian and Caucasian Patients with Chronic Hepatitis B. Alimentary Pharmacology & Therapeutics 26(10):1419-1428. 
  64. LIU WC, PHIET PH, CHIANG TY, SUN KT, HUNG KH, YOUNG KC, WU IC, CHENG PN, CHANG TT. 2007 Nov. Five Subgenotypes of Hepatitis B Virus Genotype B with Distinct Geographic and Virological Characteristics. Virus Research 129(2):212-23. (correspondence).
  65. GISH R, LOK AS, CHANG TT, MAN RA, GADANO A, SOLLANO J, HAN KH, CHAO YC, LEE SD, HARRIS M, YANG J, COLONNO R, BRETT-SMITH H. 2007 Nov. Entecavir Therapy up to 96 Weeks in Patients With HBeAg-Positive Chronic Hepatitis B. Gastroenterology 133:1437-1444.
  66. SULLIVAN SD, VEENSTRA DL, CEHN PJ, CHANG TT, CHUANG WL, TSAI C, PATEL K. 2007 Sep. Cost-effectiveness of peginterferon alfa-2a compared to lamivudine treatment in patients with hepatitis B e antigen positive chronic hepatitis B in Taiwan. Journal of Gastroenterology and Hepatology 22(9):1494-1499.
  67. WANG CS, WANG ST, YAO WJ, CHANG TT, CHOU P. 2007 July. Hepatitis C virus infection and the development of type 2 diabetes in a community-based longitudinal study. Am. J. Epidemiology 166(2):196-203.
  68. WU IC, CHOW NH, CHENG PN, LIU WC, YOUNG KC, CHANG WL, CHEN CY, TSENG KC, CHANG TT. 2007 Jun. Characterization of viral kinetics in patients with hepatitis B e antigen-positive chronic hepatitis B. Journal of Medical Virology 79:663–669. (correspondence).
  69. CHENG PN, WU IC, WANG RH, WU JC, TSENG KC, YOUNG KC, CHANG TT. 2007 Jan. Seroprevalence of Hepatitis E Virus Infection Among Institutionalized Psychiatric Patients in Taiwan. Journal of Clinical Virology 38:44–48. (correspondence).
  70. HADZIYANNIS SJ, TASSOPOULOS NC, HEATHCOTE EJ, CHANG TT, KITIS G, RIZZETTO M, MARCELLIN P, LIM SG, GOODMAN Z, MA J, BROSGART CL, BORROTO-ESODA K, ARTERBURN S, CHUCK SL, Adefovir Dipivoxil 438 Study Group. 2006 Dec. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years. Gastroenterology. 131(6):1743-51.
  71. LIU WC, MIZOKAMI M, BUTI M, LINDH M, YOUNG KC, SUN KT, CHI YC, LI HH, CHANG TT. 2006 Dec. Simultaneous Quantification and Genotyping of Hepatitis B Virus for Genotypes A to G by Real-time PCR and Two-step Melting Curve Analysis. Journal of Clinical Microbiology 44(12):4491-7. (correspondence).
  72. CHANG TT, JIA JD, OMATA M, YOON SK. 2006 Nov. New Therapies for Chronic Hepatitis B Infection. Liver International 26:30-37. (correspondence).
  73. CHEN CH, SU WW, YANG SS, CHANG TT, CHENG KS, LIN HH, WU SS, LEE CM, CHANGCHIEN CS, CHEN CJ, SHEU JC, CHEN DS, LU SN. 2006 Oct.  Long-term Trends and Geographic Variations in the Survival of Hepatocellular Carcinoma Patients: Analysis of 11,312 patients in Taiwan. Journal of Gastroenterology and Hepatology 21(10):1561-1566.
  74. LU SN, SU WW, YANG SS, CHANG TT, CHENG KS, WU JC, LIN HH, WU SS, LEE CM, CHANGCHIEN CS, CHEN CJ, SHEU JC, CHEN DS, CHEN CH. 2006 Oct.  Secular trends and geographic variations of hepatitis B virus and hepatitis C virus-associated hepatocellular carcinoma in Taiwan. Int. J. Cancer: 119(8):1946–1952.
  75. CHEN CH, CHANG TT, CHENG KS, SU WW, YANG SS, LIN HH, WU SS, LEE CM, CHANGCHIEN CS, CHEN CJ, SHEU JC, CHEN DS, LU SN. 2006 Sep. Do the young hepatocellular carcinoma patients have worse prognosis? The paradox of age as prognostic factor in the survival of hepatocellular carcinoma patients. Liver International 26: 766-771.
  76. CHANG TT, LAI CL. 2006 July. Hepatitis B virus with primary resistance to adefovir. New England Journal of Medicine 355(3):322-323. (correspondence).
  77. HUANG YH, WU JC, CHANG TT, SHEEN IJ, HUO TI, LEE PC, SU CW, LEE SD. 2006 May. Association of core promoter/precore mutations and viral load in e antigen-negative chronic hepatitis B patients. Journal of Viral Hepatitis 13(5):336-342.
  78. LAI CL, SHOUVAL D, LOK A, CHANG TT, CHEINQUER H, GOODMAN Z, DeHERTOGH D, WILBER R, ZINK R, CROSS A, COLONNO R, FERNANDES L for the AI463027 BEHoLD Study Group. 2006 Mar. Entecavir versus Lamivudine for Patients with HBeAg-Negative Chronic Hepatitis B. New England Journal of Medicine 354;1011-1020.
  79. CHANG TT, GISH RG, MAN RA, GADANO A, SOLLANO J, GOODMAN Z, ZHU J, CROSS A, DeHERTOGH D, WILBER R, COLONNO R, APELIAN D for the Entecavir BEHoLD AI463022 Study Group. 2006 Mar. A Comparison of Entecavir and Lamivudine for HBeAg-Positive Chronic Hepatitis B. New England Journal of Medicine 354;1001-1010. (correspondence).
  80. CHANG TT, GISH RG, HADZIYANNIS S, CIANCIARA J, RIZZETTO M, SCHIFF ER, PASTORE G, BACON B, POYNARD T, JOSHI S, KLESCZEWSKI KS, THIRY A, ROSE B, COLONNO R, HINDES RS. 2005 Oct. A dose ranging study of the efficacy and tolerability of entecavir in lamivudine refractory chronic hepatitis B patients. Gastroenterology 129(4):1198-1209. (correspondence)
  81. HUANG FC, SHIH MH, TSENG SH, LIN SC, CHANG TT. 2005 Jul. Tear Function Changes During Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C. Cornea 24(5):561-566.
  82. HADZIYANNIS SJ, TASSOPOULOS NC, HEATHCOTE EJ, CHANG TT, KITIS G, RIZZETTO M, MARCELLIN P, LIM SG, GOODMAN Z, MA J, ARTERBURN S, XIONG S, CURRIE G, BROSGART CL, for the Adefovir Dipivoxil 438 Study Group*. 2005 Jun. Long-term (3-year) Therapy with Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen Negative Chronic Hepatitis B. New England Journal of Medicine 352(26):2673-81.
  83. HUANG YH, CHEN CH, CHANG TT, CHEN SC, LEE PC, LEE HS, LIN PW, HUANG GT, SHEU JC, TSAI HM, CHAU GY, CHIANG JH, LUI WY, LEE SD, WU JC. 2005 May. Evaluation of predictive value of CLIP, Okuda, TNM, and JIS staging systems for hepatocellular carcinoma patients undergoing surgery. Journal of Gastroenterology and Hepatology 20(5):765-771.
  84. LEE SD, YU ML, LAI MY, CHAO YC, CHENG PN, HWANG SJ, CHANG WY, CHANG TT , HSIEH TY, LIU CJ, CHEN DS. 2005 May. Comparison of a 6-month course peginterferon a-2b plus ribavirin and interferon a-2b plus ribavirin in treating Chinese patients with chronic hepatitis C in Taiwan. Journal of Viral Hepatitis 12:283–291.
  85. HUANG YH, WU JC, CHEN CH, CHANG TT, LEE PC; CHAU GY, LUI WY, CHANG FY, LEE SD. 2005 Apr. Comparison of recurrence after hepatic resection in patients with hepatitis B vs. hepatitis C-related small hepatocellular carcinoma in hepatitis B virus endemic area. Liver International 25(2):236-241.
  86. HUANG YH, CHEN CH, CHANG TT, CHEN SC, CHIANG JH, LEE HS, LIN PW, HUANG GT, SHEU JC, TSAI HM, LEE PC, HUO TI, LEE SD, WU JC. 2005 Mar. The role of transcatheter arterial embolization for patients with unresectable hepatocellular carcinoma: a nationwide, multicentre study evaluated by cancer stage. Alimentary Pharmacology & Therapeutics 21(6):687-94.
  87. CHANG TT, LAI CL, CHIEN RN, GUAN R, LIM SG, LEE CM, NG KY, NICHOLLS G J , DENT J C , LEUNG NW. 2004 Nov.Four years of lamivudine in Chinese patients with chronic hepatitis B. Journal of Gastroenterology and Hepatology 19:1276-1282. (correspondence)
  88. HUANG YH, CHEN CH, CHANG TT, CHEN SC, WANG SY, LEE PC, LEE HS, LIN PW, HUANG GT, SHEU JC, TSAI HM, CHAU GY, CHIANG JH, LUI WY, LEE SD, WU JC. 2004 Oct. The role of transcatheter arterial embolization in patients with resectable hepatocellular carcinoma: a nation-wide, multicenter study. Liver International 24(5):419-24t
  89. CHENG PN, MARCELLIN P, BACON B, FARRELL G, PARSONS I, WEE T, CHANG TT. 2004 Sep. Racial differences in responses to interferon-β-1a in chronic hepatitis C unresponsive to interferon-��: a better response in Asian patients. Journal of Viral Hepatitis 11:418-426. (correspondence)
  90. WANG CS, YAO WJ, WANG ST, CHANG TT, CHOU P. 2004 Sep. Strong association of hepatitis C virus (HCV) infection and thrombocytopenia: implications from a survey of a community with hyperendemic HCV infection. Clin Infect Dis 15;39(6):790-6.
  91. LAI KW, YOUNG KC, CHENG PN, CHEN SH, CHANG TT. 2004 May-Jun. Interspousal transmission of hepatitis C virus: application of comparing the variability of HVR1 nucleotide region. Hepato-Gastroenterology 51(57):791-5. (correspondence)
  92. LU SN, CHOW NH, WU WC, CHANG TT, HUANG WS, CHEN SC, LIN CH and CARR BI. 2004 May. Characteristics of hepatocellular carcinoma in a high arsenicism area in Taiwan: a case-control study. Journal of Occupational & Environmental Medicine 46(5):437-41.
  93. CHUNG CH, YANG YH, CHANG TT, SHIEH DB, LIU SY, SHIEH TY. 2004 Apr. Relationship of oral lichen planus to hepatitis C virus in southern Taiwan. Kaohsiung Journal of Medical Sciences 20(4):151-9.
  94. CHEN CH, CHEN YY, CHEN GH, YANG SS, TANG HS, LIN HH, LIN DY, LO SK, DU JM, CHANG TT, CHEN SC, LIAO LY, KUO CH, LIN KC, TAI DI, CHANGCHIEN CS, CHANG WY, SHEU JC, CHEN DS, LIAW YF, and SUNG JL. 2004 Apr. Hepatitis B virus transmission and hepatocarcinogenesis: a nine year retrospective cohort of 13,676 relatives with hepatocellular carcinoma. J Hepatology 40(4):653-659.
  95. TSAI YM, CHOU NW, CHENG PN, CHANG TT. 2003 Oct. Primary biliary cirrhosis with negative anti-mitochonddrial antibody: a case report. Tzu Chi Med J 15(5):347-350. (correspondence)
  96. WANG CS, WANG ST, YAO WJ, CHANG TT, CHOU P. 2003 Dec. Community-based study of hepatitis C virus infection and type 2 diabetes: an association affected by age and hepatitis severity status. American Journal of Epidemiology 158(12):1154-60.
  97. TSENG KC, LEI HY, CHENG PN, YOUNG KC, JEN CM, WU CH, CHANG TT. 2003 Sep.-Oct.  Immune response to hepatitis B vaccine of subjects with isolated antibody to hepatitis B core antigen. Hepato-Gastroenterology. 50:1474-1477 (correspondence).
  98. HUANG YH, WU JC, CHANG TT, SHEEN IJ, LEE PC, HUO TI, SU CW, WANG YJ, CHANG FY, LEE SD. 2003 Jul. Analysis of clinical biochemical and viral factors associated with early relapse after lamivudine treatment for hepatitis B e antigen-negative chronic hepatitis B patients in Taiwan. Journal of Viral Hepatitis 10: 277-284.
  99. SHIEH B, CHANG MJ, KO WC, CHEN EJ, WU JC, LEE CF, CHANG TT, LI C. 2003 Apr. Effects of multiple virus coinfections on disease progression in HIV-positive patients. Intervirology 46(2):105-113.
  100. CHENG PN, JEN CM, YOUNG KC, CHEN CY, LU SN, WANG CS, CHANG TT. 2003 Mar.-Apr. High-dose interferon-α2b plus ribavirin combination therapy for GB virus-C/hepatitis G virus infection-a study in patients with chronic hepatitis C. Hepato-Gastroenterology 50:449-452. (correspondence)
  101. HADZIYANNIS SJ, TASSOPOULOS NC, HEATHCOTE EJ, CHANG TT, KITIS G, RIZZETTO M, MARCELLIN P, LIM SG, GOODMAN Z, WULFSOHN MS. XIONG S, FRY J, BROSGART OS, for the Adefovir Dipivoxil 438 Study Group. 2003 Feb. Adefovir dipivoxil for the treatment of hepatitis B e antigen–negative chronic hepatitis B. New England Journal of Medicine 348(9):800-807.
  102. MARCELLIN P, CHANG TT, LIM SG, TONG MJ, SIEVERT W, SHIFFMAN M, JEFFERS L GOODMAN Z, WULFSOHN MS, XIONG S, FRY John, BROSQART C, for the Adefovir Dipivoxil 437 Study Group. 2003 Feb. Adefovir dipivoxil for the treatment of hepatitis B e antigen–positive chronic hepatitis B. New England Journal of Medicine 348(9):808-816.
  103. CHENG PN, CHANG TT, JEN CM, YOUNG KC. 2003 Jan.-Feb.. Molecular evidence for transmission of GB virus-C / hepatitis G virus infection within family: close relationship between mother and child. Hepato-Gastroenterology 50:151-156.
  104. WANG CJ, CHANG YJ, YEH LILY, CHANG TT. 2002 Dec. Endemic hepatitis C virus infection in a seaboard village of southwestern Taiwan. The Journal of Nursing Research 10(4):246-252. (correspondence)
  105. CHENH PN, CHOW NH, HU SC, YOUNG KC, CHEN CY, JEN CM, CHANG TT. 2002 Dec. Clinical comparison of high-dose interferon-alpha2b with or without ribavirin for treatment of interferon-relapsed chronic hepatitis C. Digestive & Liver Disease 34(12):851-6. (correspondence)
  106. CHANG YC, HO CL, CHEN HELEN HW, CHANG TT, LAI WW, DAI YC, LEE WY, CHOW NH. 2002 Dec. Molecular diagnosis of primary liver cancer by microsatellite DNA analysis in the serum. British Journal of Cancer 87(12):1449-1453
  107. YOUNG KC, LIN PW, HSIAO WC, CHANG TT, CHANG YC, WU HL. 2002 Oct. Variation of hepatitis C virus load, hypervariable region 1 quasispecies and CD81 hepatocyte expression in hepatocellular carcinoma and adjacent non-cancerous liver. J Med Virol 68(2):188-96
  108. YAO WJ, WANG ST, CHOW NH, CHANG TT, LIN PW, TU DG. 2002 Jul. Serum tissue polypeptide specific antigen as a noninvasive prognostic indicator for early recurrence of hepatocellular carcinoma after curative resection. Cancer 95(1):112-8.
  109. TAI DI, CHEN CH, CHANG TT, CHEN SC, LIAO LY, KUO CH, CHEN YY, CHEN GH, YANG SS, TANG HS, LIN HH, LIN DY, LO SK, DU JM, LIN KC, CHANG, CHIEN CS, CHANG WY, SHEU JC, LIAW YF, CHEN DS AND SUNG JL. 2002 Jun. Eight-year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection. Journal of Gastroenterology and Hepatology 17(6):682-689.
  110. YOUNG KC, CHANG TT, WEI CH, CHENG PN, CHEN SH, JEN CM. 2002 May. A reverse-transcription competitive PCR assay based on chemiluminescence hybridization for detection and quantification of hepatitis C virus RNA. Journal of Virological Methods 103:27-39.
  111. WANG CS,CHANG TT, YAO WJ, CHOU P. 2002 Apr. Comparison of hepatitis B virus and hepatitis C virus prevalence and risk factors in a community-based study. American Journal of Tropical Medicine & Hygiene 66(4):389-93.
  112. WANG CS, WANG ST, CHANG TT, TAO WJ, CHOU PESUS. 2002 Apr. Smoking and alanine aminotransferase levels in hepatitis C virus infection-implications for prevention of hepatitis C virus progression. Arch Intern Med 162:811-815.
  113. YAO WJ, CHANG TT, WANG ST, CHOW NH, LIN PW, CHANG YC, TU DG, CHIU NT. 2001. Clinicopathological correlation of serum tissue polypeptide specific antigen in hepatocellular carcinoma. Oncology 61(1):64-70
  114. LIN CC, WU JC, CHANG TT, HUANG YH, WANG YJ, TSAY SH, CHOW NH, CHANG FY, LEE SD. 2001 Nov. Long-term evaluation of recombinant interferon 2b in the treatment of patients with hepatitis B e antigen-negative chronic hepatitis B in Taiwan. Journal of Viral Hepatitis 8(6):438-446.
  115. CHANG TT, CHANG TY, CHEN CC, YOUNG KC, ROAN JN, LEE YC, CHENG PN, WU HL. 2001 Sep. Existence of hepatitis C cirus in Culex quinquefasciatus after taking infected blood: experimental approach to evaluating the transmission by mosquitoes. Journal of Clinical Microbiology 39(9):3353-3355. (correspondence)
  116. JEN CM, YOUNG KC, CHENG PN, KAO AW, CHANG TT. 2001 Aug. Limitations and improvements of Chiron Quantiplex branched-DNA assay in hepatitis B virus-infected patients receiving Lamivudine. Journal of Virological Methods 96(2):203-10. (correspondence)
  117. HUANG JJ, LEE WC, RUAAN MK, WANG MC, CHANG TT, YOUNG KC. 2001 Jun. Incidence, transmission, and clinical significance of hepatitis G virus infection in hemodialysis patients. Eur J Clin Microbiol Inf Dis 20:374-379.
  118. LEUNG NWY, LAI CL, CHANG TT, GUAN R, LEE CM, NG KY, LIM SG, WU PC, DENT JC, EDMUNDSON S, CONDREAY LD, CHIEN RN on behalf of the Asia Hepatitis Lamivudine Study Group. 2001 Jun. Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after three years of therapy. Hepatology 33(6):1527-1532
  119. YOUNG KC, LIEN HM, LIN CC, CHANG TT, LEE GB, CHEN SH. 2001 May. Microchip and capillary electrophoresis for quantitative analysis of hepatitis C virus based on RT-competitive PCR. Talanta 56:323-330.
  120. FAN YF, LU CC, CHEN WC, YAO WJ, WANG HC, CHANG TT, LEI HY, SHIAU AL, SU IJ. 2001 Jan. Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection. Hepatology 33:277-286.
  121. LIN YC, HWANG MY, YOUNG KC, CHANG TT, WU CY. 2000. A rapid micro-PCR system for hepatitis C virus amplification. Sensors and Actuators B 71: 2-8
  122. LIN CC, WU JC, CHANG TT, CHANG WY, YU ML, TAM AW, WANG SC, HUANG YH, CHANG FY, LEE SD. 2000 Nov. Diagnostic value of immunoglobulin G (IgG) and IgM anti-hepatitis E virus (HEV) tests based on HEV RNA in an area where hepatitis E is not endemic. Journal of Clinical Microbiology 38(11):3915-3918.
  123. LEE PC, HUNG CJ, LEI HY, CHANG TT, WANG JR, JAN MS. 2000 Sep. Parvovirus B19-related acute hepatitis in an immunosuppressed kidney transplant. Nephrology, Dialysis, Transplantation 15(9):1486-8.
  124. LIAW YF, LEUNG NWY, CHANG TT, GUAN R, TAI DI, NG KY, CHIEN RN, DENT J, ROMAN L, LAI CL. 2000 Jul. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Gastroenterology 119(1):172-180.
  125. CHENG PN, CHANG TT, YANG MH, HU SC, YOUNG KC, WU HL, JEN CM, KO AW, LU SC. 2000 Jun. GB virus-C/hepatitis G virus infection in a hepatitis C virus endemic village – more prevalent in residents with low education attainment, frequent recovery in females. Liver 20(3):222-227. (correspondence)
  126. FAN YF, LU CC, CHANG YC, CHANG TT, LIN PW, LEI HY, SU IJ. 2000 May. Identification of pre-S2 mutant in hepatocytes expressing a novel marginal pattern of surface antigen in advanced diseases of chronic hepatitis B virus infection. Journal of Gastroentology and Hepatology 15(5):519-528.
  127. CHEN YH, WANG WC, YOUNG KC, CHANG TT, CHEN SH. 1999 Nov. Plastic microchip electrophoresis for analysis of PCR products of hepatitis C virus.  Clinical Chemistry 45:11 1938-1943.
  128. KUO CH, CHENG PN, YAO WJ, JEN CM, KAO AW, CHANG TT. 1999 Jun. Rendu-Osler-Weber syndrome with portal systemic shunts and hepatic encephalopathy: report of a case. Gastroenterological Journal of Taiwan 16(2):173-178. (correspondence)
  129. YANG SH, LIN CY, YOUNG KC, CHENG PN, CHANG TT. 1999 Jun. Prevalence of HCV infection among spouses. Gastroenterological Journal of Taiwan 16(2):155-160. (correspondence)
  130. TU DG, WANG ST, CHANG TT, CHIU NT, YAO WJ. 1999 Mar. The value of serum tissue polypeptide specific antigen in the diagnosis of hepatocellular carcinoma. Cancer 85(5): 1039-1043.
  131. WU CL, LEU TS, CHANG TT, SHIAU AL. 1999 Feb. Hepatitis C virus core protein fused to hepatitis B virus core antigen for serodiagnosis of both hepatitis C and hepatitis B infections by ELISA. J Med Virol 57(2):104-110.
  132. HOR LI, CHANG TT, WANG ST. 1999 Jan. Survival of Vibrio vulnificus in whole blood from patients with chronic liver disease: association with phagocytosis by neutrophils and serum ferritin levels. The Journal of Infectious Disease 179(1): 275-278.
  133. CHENG PN, SHEU BS, CHEN CY, CHANG TT, LIN XZ. 1998. Oct. Splenic infection after histoacryl injection for bleeding gastric varices. Gastrointestinal Endoscopy 48(4):426-427.
  134. WANG CS, CHANG TT, CHOU P. 1998 Sep. Differences in risk factors for being either a hepatitis B carrier or anti-hepatitis C+ in a hepatoma-hyperendemic area in rural Taiwan. J Clin Epidemiol 51(9):733-738.
  135. LAI CL, CHIEN RN, LEUNG NWY, CHANG TT, GUAN R, TAI DI, NG KY, WU PC, DENT JC, BARBER J, STEPHENSON SL, GRAY DF. 1998 Jul. A one year trial of Lamivudine for chronic hepatitis B. New Engl J Med 339(2):61-68.
  136. WANG CS, CHANG TT, CHOU P. 1998 Mar. Differing characteristics of hepatitis B and C risk factors among the elderly in a rural area in Taiwan. J of Gerontology: Medical & Sciences 53(2):M107-11.
  137. HUANG YJ, SHEU BS, YANG HB, CHEN CC, CHANG TT, LIN XZ. 1997 Jun. Tuberculosis of stomach, ileum and colon: report of a case. Chinese J Gastroenterol 14(2):204-210.
  138. HSU MT, LIN XZ, CHANG TT, SHIN JS, CHEN CY, SHEU BS. 1996 Jun. Sequential endoscopic findings in spontaneous intramural hematoma of the esophagus. Endoscopy 28(5):465
  139. CHANG TT, YOUNG KC, YANG YJ, LAI KA, WU HL, WU MH, CHEN MY, LIN XZ, LIN CY, SHIN JS. 1996 Jun. Incidence of Posttransfusion Hepatitis in Taiwan before and after introduction of anti-HCV testing. Liver 16(3):201-206. (correspondence)
  140. CHANG TT, YOUNG KC, YANG YJ, LEI HY, WU HL. 1996 May. Hepatitis C virus RNA in peripheral blood mononuclear cells: comparing acute and chronic hepatitis C virus infection. Hepatology 23(5):977-981. (correspondence)
  141. SHEU BS, SHIN JS, LIN XZ, LIN CY, CHEN CY, CHANG TT, CHEN CY. 1996 Jan. Clinical analysis of choledochoduodenal fistula with cholelithiasis in Taiwan: assessment by endoscopic retrograde cholangiopancreatography. Am J Gastroenterol 91(1):122-126.
  142. CHEN CY, CHANG TT, LIN CY, SHIN JS, CHEN CY, CHI CH, SHEU BS, LIN XZ. 1995 Dec. Endoscopic variceal ligation versus conservative treatment for patients with hepatocellular carcinoma and bleeding esophageal varices. Gastrointestinal Endoscopy 42(6):535-539.
  143. CHEN CY, LIN XZ, SHIN JS, LIN CY, LEOW TC, CHEN CY, CHANG TT. 1995 Oct. Spontaneous rupture of hepatocellular carcinoma: a review of 141 Taiwanese cases and comparison with nonrupture cases. J Clin Gastroenterol; 21(3):238-242. (correspondence)
  144. HSU MT, CHANG TT, LIN PW, TSAI HM, LEE WY, LIN XZ. 1995 Jan. Chronic calcifying pancreatitis complicated with pancreatic cancer - a case report. Tzu-Chi Med J 7(1):59-65.
  145. CHEN CY, LIN CY, CHANG TT, SHIN JS. 1995 Jan. A simple maneuver for placing an overtube during endoscopic variceal ligation. Gastrointestinal Endoscopy 41(1):83-4.
  146. CHEN CL, HUANG SM, CHIEN CH, CHANG TT, YU CY, LEE JC. 1994 Oct. Successful resection of a minute icteric hepatocellular carcinoma--case report. Hepato-Gastroenterology 41(5):503-505.
  147. SHIN JS, CHEN KW, LIN XZ, LIN CY, CHANG TT, YANG CC. 1994 Oct. Active bleeding marginal ulcer of Billroth II gastric resection: a clinical experience of 18 patients. Am J Gastroenterol 89:1831-1835.
  148. YANG CC, SHIN JS, LIN XZ, HSU PI, LIN CY, CHANG TT, TSAI HM, CHOW NH. 1994 Sep. Fundic gland polyposis in patient without familial adenomatosis coli - a case report with atypical clinical presentation and location. Tzu-Chi Med J 6(3):203-208.
  149. SHEU BS, CHANG TT, SHIN JS, LIN PW, LIN XZ, TSAI HM, TSERNG CT, LIN CY. 1994 Sep. Primary infarction of greater omentum: report of a case. Chinese J Gastroenterol 11(3):213-218.
  150. CHEN CY, LIN CY, CHANG TT, SHIN JS, CHEN CY, YANG CC, LEOW TC, SHEU MJ, LIN XZ. 1994 Sep. Endoscopic variceal ligation for the treatment of bleeding esophageal varices. Chinese J Gastroenterol 11(3):187-193.
  151. HSU PI, LIN XZ, CHAN SH, LIN CY, CHANG TT, SHIN JS, HSU LY, YANG CC, CHEN KW. 1994 Jun. Bleeding peptic ulcer - risk factors for rebleeding and sequential changes in endoscopic findings. Gut 35(6):746-749.
  152. CHEN CY, LIN XZ, LIN CY, CHANG TT, SHIN JS, YANG CC, LIN PW, TSAI HM. 1994 Apr. Colon involvement in acute pancreatitis. J Clin Gastroenterol 18(3):243-245.
  153. MENG HC, LIN HC, TSAI YT, LEE FY, LIAO DM, HSIA HC, LIN WJ, CHANG TT, LAY CS, WANG SS, LEE SD, LO KJ. 1994 Mar.-Apr. Relationships between the severity of cirrhosis and haemodynamic values in patients with cirrhosis. J Gastroenterol Hepatol 9(2):148-153.
  154. LIN CY, LIN PW, TSAI HM, LIN XZ, CHANG TT, SHIN JS. 1994 Mar. Influence of paraesophageal venous collaterals on efficacy of endoscopic sclerotherapy for esophageal varices. Hepatology 19(3):602-608.
  155. HSU PI, LIN XZ, LIN CY, CHANG TT, SHIN JS, HUANG JJ, TSAI HM, CHEN KH, CHIU NT, LAI KH, LIN M, YANG YF. 1994 Mar. Cholangiographic CT in differential diagnosis of Caroli's disease and polycystic liver disease - a preliminary study. Chinese J Gastroenterol 11(1):1-10.
  156. CHANG TT, LIN CY, CHOW NH, HSU PI, YANG CC, LIN XZ, SHIN JS, CHEN DS. 1994 Feb. Hepatitis B and hepatitis C virus infection among chronic alcoholic patients with liver disease in Taiwan. J Formos Med Assoc 93(2):128-133. (correspondence)
  157. CHANG TT, LIOU TC, YOUNG KC, LIN XZ, LIN CY, SHIN JS, WU HL. 1994 Jan.  Intrafamilial Transmission of Hepatitis C Virus: The Important Role of Inapparent Transmission. J Med Virol 42(1):91-96. (correspondence)
  158. YANG CC, CHEN CY, LIN XZ, CHANG TT, SHIN JS, LIN CY. 1993 Nov. Pyogenic liver abscess in Taiwan: emphasis on gas-forming liver abscess in diabetics. Am J Gastroenterol 88(11):1911-1915.
  159. YOUNG KC, CHANG TT, LIOU TC, WU HL. 1993 Sep. Detection of hepatitis C virus RNA in peripheral blood mononuclear cells and in saliva. J Med Virol 41(1):55-60.
  160. CHANG TT, HSU PI, CHIU NT, YAO WJ, CHENG JT, PENG CJ, LIOU TC, LIN CY, LIN XZ, SHIN JS. 1993 Sep. The differences in renal hemodynamics and plasma catecholamine levels between cirrhotic patients with and without ascites. Chinese J Gastroenterol 10(3):204-211. (correspondence)
  161. CHANG TT, LIN H, YEN YS, WU HL. 1993 Jun. Hepatitis B and hepatitis C among institu­tionalized psychiatric patients in Taiwan. J Med Virol 40(2):170-173. (correspondence)
  162. LIN XZ, CHANG KK, SHIN JS, CHANG TT, LIN CY. 1993 Mar.-Apr. Endoscopic nasobiliary drainage for acute suppurative cholangitis: a sonographically guided method. Gastroenterol Endosc 39(2):174-176.
  163. SUNG JM, HUANG JJ, LIN XZ, RUAAN MK, LIN CY, CHANG TT, SU FHF, CHOU NH. 1992 Dec. Caroli's disease and congenital hepatic fibrosis associated with polycys­tic kidney disease. A case presenting with acute focal bacterial nephritis. Clinical Nephrology 38(6):324-328.
  164. LIOU TC, CHANG TT, YOUNG KC, LIN XZ, LIN CY, WU HL. 1992 Jul. Detection of HCV RNA in saliva, urine, seminal fluid and ascites. J Med Virol 37(3):197- 202. (correspondence)
  165. HSU PI, CHANG TT, LIN XZ, LIN CY, SHIN JS, HUANG JJ, CHENG JJ, SHU GHF, CHOU NH. 1992 Jun. Hepatobiliary fibropolycystic diseases in Taiwan - a clinical study of 51 cases. Chinese J Gastroenterol 9(2):157-162.
  166. LIN XZ, LIN CY, CHANG TT, SHIN JS, LIOU TC, CHANG KK. 1992 May-Jun. Choledocholithiasis treated by ethylenediaminetetraacetic acid infusion through an endoscopic nasobiliary catheter. J Gastroenterol Hepatol 7(3):335-338.
  167. LIOU TC, LIN XZ, CHANG TT, LIN CY, LIN PW, JIN YT, YU CY. 1992 Mar. Pancreas divisum with early pancreatic cancer - presenting as chronic obstructive pancreatitis. Pancreas 7(2):251-256.
  168. CHANG TT, LEE FY, TSAI YT, LAI KH, CHAO Y, HSIA HC, LIN HC, WANG SS, LEE SD, LO KW. 1991 Sep.-Oct. A randomized controlled study of low dose and high dose ter­lipressin in the control of acute esophageal variceal haemorrhage. J Gastroenterol Hepatol 6(5):481-484. (correspondence)
  169. LEI HY, WANG JY, CHANG TT, WANG CC. 1991 Feb. Hepatitis B surface antigen induces an early-type hypersensitivity. Clin Exp Immunol 83(2):210-214.
  170. LIN HC, TSAI YT, LEE FY, CHANG TT, WANG SS, LAY CS, LEE SD, LO KJ. 1990 May. Systemic and portal hemodynamic changes following triglycyllysine vasopressin plus nitroglycerin administration in patients with hepatitis B-related cirrhosis. J Hepatol 10(3):370-374.
  171. LIN HC, TSAI YT, LEE FY, CHANG TT, WANG SS, LAY CS, LEE SD, LO KJ. 1989 Nov. Comparison between portal vein pressure and wedged hepatic vein pressure in hepatitis B related cirrhosis. J Hepatol 9(3):326-330.
  172. CHAO Y, LEE FY, TSAI YT, LIN HC, CHANG TT, WANG SS, WU JC, LAI KH, LEE SD, LO KJ. 1989 Sep. Muscle cramps in liver cirrhosis. Chinese J Gastroenterol 6(3):163-169.
  173. TSAI YT, LEE FY, LIN HC, CHANG TT, LAY CS, WANG SS, KONG CW, LEE SD, LO KJ. 1989 Sep. Lack of effects of isosorbide-5-mononitrate on hepatic hemodynamics in HBsAg-positive cirrhosis. Hepatology 10(3):283-287.
  174. CHANG TT, LIN HC, LEE SD, TSAI YT, LEE FY, JENG FS, WU JC, YEH PS, LO KJ. 1989 Jun. Clinical significance of serum type III procollagen aminopropeptide in hepatitis B virus related liver diseases. Scand J Gastroenterol 24(5):533-538.
  175. LIN HC, TSAI YT, CHANG TT, LEE FY, WANG SS, LAY CS, LEE SD, LO KJ. 1989 Feb. Haemodynamic effects of triglycyl-lysine vasopressin plus nitroglycerin in patients with HBsAg-positive cirrhosis. J Gastroenterol Hepatol 4(Suppl 1):224-227.
  176. LIN HC, TSAI YT, LEE SD, CHANG TT, LEE FY, WANG SS, HUANG YS, LAY CS, LO KJ. 1988 Dec. Measurement of portal and splenic blood flow by pulsed Doppler ultrasound in normal subjects and patients with HBsAg-positive chronic liver dis­ease. Chinese J Gastroenterol 5(4):193-200.
  177. LAY CS, TSAI YT, KONG CW, LEE FY, CHANG TT, LIN HC, YANG CM, LEE SD, CHIANG BN, LO KJ. 1988 Oct The influence of verapamil and nifedipine on hepatic indocyanine green clearance in patients with HBsAg-positive cirrhosis and ascites. Clin Pharmacol Ther 44(4):453-457.
  178. LEE FY, TSAI YT, LAI KH, LAY CS, CHANG TT, MALIK U, LIN CY, LEE SD. 1988 Sep. A randomized controlled study of triglycyl-vasopressin and vasopressin plus nitroglycerin in the control of acute esophageal variceal hemorrhage. Chinese J Gastroenterol 5(3):131-138.
  179. CHANG TT, LIN CK, CHIANG YM, CHAU WK, CHEN SZ, LIAO CM. 1988 Sep. False blood cell indices caused by cryoglobulin and cold hemagglutinin. Chin Med J (Taipei) 42(3):169-174.

 

 
實驗室
 
  實驗室操作技術:
  1. 基因轉殖

  2. 基因表現之定性分析

  3. 核酸與蛋白純化

  4. 核酸即時聚合酶連鎖反應分析

  5. 流式細胞分析

  6. 次世代定序(NGS)與單核苷酸多型性(SNP)研究分析

 

實驗室花絮

 

主治醫師 : 4
專任研究助理 : 2
博士班學生 : 2
碩士班學生 : 0

 

 

瀏覽數:
加到我的最愛