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鄧景浩 Ching-Hao Teng

Ching-HaoTeng

鄧景浩副教授(Ching-Hao Teng)

E-mail:chteng@mail.ncku.edu.tw 

電話:06-2353535 分機4595

傳真:06-2095845

 

學經歷

 

學歷 1996 –2002 美國康乃爾大學  比較生物醫學博士
  1987 –1992 國立台灣大學      獸醫系學士

 

現職 2012~present 國立成功大學醫學院分子醫學研究所 副教授

  

經歷 2005-2012 國立成功大學醫學院分 子醫學研究所助理教授

 

2002-2005 Post-doctoral fellow, Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University, Baltimore,Maryland, USA

 

2001-2002 Post-doctoral fellow, Department of Medicine, University of Maryland, Division of Infectious Diseases, Baltimore, Maryland, USA
  1997-2000 Graduate Research Assistant, Department of Population Medicine and Diagnostic Science, Cornell University, Ithaca, New York, USA
  1995-1996 Research Assistant, Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
  1994-1995 Veterinarian, Chung Sun Animal Clinic, Yung Ho City, Taiwan

 

專長/研究興趣

 

細菌遺傳及致病機制、分子生物學  

 

興趣:

  由於抗生素濫用,新的抗藥性細菌不斷產生。近年來陸續發現帶有多重抗藥性的"超級細菌"。這類抗藥性細菌出現的速度已超越新型抗生素的研發速度,再加上因為人類旅行日漸便利的推波助瀾,這類細菌也快速的散佈全球。這種狀況已經對於醫學界以抗生素來控制感染性疾病的方式帶來隱憂,也對人類健康造成嚴重威脅。因此,對於致病性細菌發展新的預防以及治療策略刻不容緩。

本實驗室的長程目標就是要發展出新的預防及治療策略以對抗不斷演化的致病性細菌。為達此目標,我們從了解細菌致病的機轉著手。因為在了解了致病性細菌入侵人類的過程中如何和宿主交互作用以逃離免疫系統攻擊及獲得生存所需的養分,將有助於找出可能的切入點。致病性大腸桿菌是最常見的人類致病性細菌之一。而且大腸桿菌也是至今為止,人類研究最多的細菌。因此,我們以致病性大腸桿菌為模型,進行其致病機轉研究。而現今,實驗室以研究造成新生兒腦膜炎的K1莢膜大腸桿菌以及泌尿道致病性大腸桿菌為主。

       要引起新生兒腦膜炎,K1莢膜大腸桿菌須先在血流中增殖達到一定數目才能穿越血腦障壁進入中樞神經系統。我們正在研究此細菌如何躲避人類血流中的免疫系統的擊殺而繼續增殖,以及它如何和構成血腦障壁的腦微血管內皮細胞交互作用達到穿越血腦障壁的目的。泌尿道致病性大腸桿菌會感染膀胱以及腎臟。在感染過程中,此菌會入侵到泌尿道上皮細胞、抑制宿主免疫反應以及造成細胞凋亡。實驗室正在研究這些反應的機制。

 

研究成果 (Publications) -- Ching-Hao Teng

 
 A. 期刊論文 Refereed Papers ( Journal Articles )
  1. Li HY, Kao CY, Lin WH, Zheng PX, Yan JJ, Wang MC, Teng CH, Tseng CC, Wu JJ. Characterization of CRISPR-Cas Systems in Clinical Klebsiella pneumoniae Isolates Uncovers Its Potential Association With Antibiotic Susceptibility.Front Microbiol. 2018 Jul 16;9:1595. doi: 10.3389/fmicb.2018.01595. eCollection 2018.

  2. Kao CY, Wu HM, Lin WH, Tseng CC, Yan JJ, Wang MC, Teng CH, Wu JJ.(2016)Plasmid-mediated quinolone resistance determinants in quinolone-resistant Escherichia coli isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015. Sci Rep. 6:32281. doi: 10.1038/srep32281.Impact factor 5.228 , Ranking 4/111 (3.6%)

  3. Kuo CJ, Chen JW, Chiu HC, Teng CH, Hsu TI, Lu PJ, Syu WJ, Wang ST, Chou TC, Chen CS. (2016) Mutation of the Enterohemorrhagic Escherichia coli Core LPS Biosynthesis Enzyme RfaD Confers Hypersusceptibility to Host Intestinal Innate Immunity In vivo. Front Cell Infect Microbiol. 6(82) ?doi: 10.3389/fcimb.Impact factor 5.218, Ranking 18/123 (14.63%)

  4. Wang Y.H., Chen H. M., Yang Y. H., Yang T. H., Teng Ching-Hao , Chen C. L., Chu C, Chiu C. H..Clinical and microbiological characteristics of recurrent group B streptococcal infection among non-pregnant adults.International Journal of Infectious Diseases(2014 Dec) 26: 140-5

  5. Y. W. Chen*, Ching-Hao Teng*, Y. H. Ho, T. Y. Ho, W. C. Huang, M. Hashimoto, I. Y. Chiang, and C. S. Chen. (2014) Identification of Bacterial Factors Involved in Type 1 Fimbria Expression using an Escherichia coli K12 Proteome Chip. Molecular and Cellular Proteomics. Molecular & cellular proteomics. (SCI). First Published on April 1, 2014, doi:10.1074/mcp.M113.035667 13(6):1485-94*Equal contribution to first authors.

  6.  W. H. Lin, C. Y. Kao, D. C. Yang, C. C. Tseng, A. B. Wu, Ching-Hao Teng, M. C. Wang J. J. Wu. (2014) Clinical and microbiologic characteristics of Klebsiella pneumoniae from community-acquired recurrent urinary tract infections. European journal of clinical microbiology & infectious diseases (SCI). 33:1533-9.  

  7.  M. C. Wang, W. H. Lin, C. C. Tseng, A. B. Wu, Ching-Hao Teng, J. J. Yan, J. J. Wu. (2013/3) Role of K1 capsule antigen in cirrhotic patients with Escherichia coli spontaneous bacterial peritonitis in southern Taiwan. European journal of clinical microbiology & infectious diseases. 32:407-412. (SCI).

  8.  M. C. Wang, C. C. Tseng, An. B. Wu, W. H. Lin, Ching-Hao Teng, J. J. Yan, J. J. Wu. (2013/2) Bacterial characteristics and glycemic control in diabetic patients with Escherichia coli urinary tract infection. Journal of microbiology, immunology and infection. 46:24-29. (SCI).

  9. Y. T. Tseng, S. W. Wang, K. S. Kim, Y. H. Wang, Y. Yao, C. C. Chen, C. W. Chiang, P. C. Hsieh, and Ching-Hao Teng*. (2012/10) NlpI facilitates deposition of C4bp on Escherichia coli by blocking classical complement-mediated killing, which results in high-level bacteremia. Infection and immunity. 80:3669-3678. (SCI). *Corresponding Author.

  10. C. Y. Wang, S. W. Wang, W. C. Huang, K. S. Kim, N. S. Chang, Y. H. Wang, M. H. Wu, and Ching-Hao Teng*. (2012/10) Prc contributes to Escherichia coli evasion of classical complement-mediated serum killing. Infection and immunity. 80: 3399-3409. (SCI). *Corresponding Author.

  11. T. Janvilisri, J. Scaria, Ching-Hao Teng, S. P. McDonough, R. D. Gleed, S. L Fubini, S. Zhang, B. L. Akey, Y. F. Chang. (2012/9) Temporal differential proteomes of Clostridium difficile in the pig ileal-ligated loop model. PLoS One. 7:e45608. (SCI).

  12. Y. F. Liu, J. J. Yan, H. Y. Lei, Ching-Hao Teng, M. C. Wang, C. C. Tseng, and J. J. Wu. (2012/5) Loss of outer membrane protein C in Escherichia coli contributes to both antibiotic resistance and escaping antibody-dependent bactericidal activity. Infection and immunity. 80: 1815-1822. (SCI).

  13. B. H. Mao, Y. F. Chang, J. Scaria, C. C. Chang, L. W. Chou, N. Tien, J. J. Wu, C. C. Tseng, M. C. Wang, C. C. Chang, Y. M. Hsu, and Ching-Hao Teng*. (2012/2) Identification of Escherichia coli genes associated with urinary tract infections. Journal of clinical microbiology. 50:449-456. (SCI). *Corresponding Author.

  14. Wu, A. B., M. C. Wang, C. C. Tseng, W. H. Lin, Ching-Hao Teng, A. H. Huang, K. H. Hung, C. Chiang-Ni, and J. J. Wu. (2011/8) Clinical and microbiological characteristics of community-acquired Staphylococcus lugdunensis infections in southern Taiwan. Journal of clinical microbiology 49:3015-3018. (SCI)

  15. S. M. Faisal, J. W. Chen, S. P. McDonough, C. F. Chang, Ching-Hao Teng, and Y. F. Chang. (2011/3) Immunostimulatory and antigen delivery properties of liposomes made up of total polar lipids from non-pathogenic bacteria leads to efficient induction of both innate and adaptive immune responses. Vaccine. 29:2381-2391. (SCI)

  16. J. Scaria, L. D. Warnick, J.B. Kaneene, K. May, Ching-Hao Teng, and Y. F. Chang. (2010/12) Comparison of phenotypic and genotypic antimicrobial profiles in Escherichia coli and Salmonella enterica from the same dairy cattle farms. Molecular and Cellular Probes. 24:325-45. (SCI)

  17. Ching-Hao Teng, Y. T. Tseng, R. Maruvada, D. Pearce, Y. Xie, M. Paul-Satyaseela, and K. S. Kim. (2010/7) NlpI contributes to Escherichia coli K1 strain RS218 interaction with human brain microvascular endothelial cells. Infection and immunity. 78:3090-3096. (SCI)

  18. C. S. Chiou, H. Y. Li, S. K. Tung, C. Y. Chen, Ching-Hao Teng, J. C. Shu, J. T. Tseng, C. Y. Hsu, and C. C. Chen. (2010/6) Identification of prophage gene z2389 in Escherichia coli EDL933 encoding a DNA cytosine methyltransferase for full protection of NotI sites. International journal of medical microbiology. 300: 296-303. (SCI)

  19. Y. Xie, G. Parthasarathy, F. Di Cello, Ching-Hao Teng, M. Paul-Satyaseela, and K. S. Kim. (2008/1). Transcriptome of Escherichia coli K1 bound to human brain microvascular endothelial cells. Biochemical and biophysical research communications. 365:201-206. (SCI)

  20. Ching-Hao Teng, Y. Xie, S. Shin, F. Di Cello, M. Paul-Satyaseela, M. Cai, and K. S. Kim. (2006/10) Effects of ompA deletion on expression of type 1 fimbriae in Escherichia coli K1 strain RS218 and on the association of E. coli with human brain microvascular endothelial cells. Infection and immunity. 74:5609-5616. (SCI)

  21. Y. Xie, Y. Yao, V. Kolisnychenko, Ching-Hao Teng, and K. S. Kim. (2006/7) HbiF regulates type 1 fimbriation independently of FimB and FimE. Infection and immunity. 74:4039-4047. (SCI)

  22. J. Lee, S. Shin, Ching-Hao Teng, S. J. Hong, and K. S. Kim. (2005/7) FimH adhesin of Escherichia coli K1 type 1 fimbriae activates BV-2 microglia. Biochemical and biophysical research communications. 334:917-923. (SCI)

  23. Ching-Hao Teng, M. Cai, S. Shin, Y. Xie, K. J. Kim, N. A. Khan, F. Di Cello, and K. S. Kim. (2005/5) Escherichia coli K1 RS218 interacts with human brain microvascular endothelial cells via type 1 fimbria bacteria in the fimbriated state. Infection and immunity. 73:2923-31. (SCI)

  24. Ching-Hao Teng, R. U. Palaniappan, and Y. F. Chang. (2003/4) Cloning and characterization of an Ehrlichia canis gene encoding a protein localized to the morula membrane. Infection and immunity. 71:2218-25. (SCI)

  25. Ching-Hao Teng, S. C. Barr, and Y. F. Chang. (2003/4) Cloning and characterization of putative zinc protease genes of Ehrlichia canis. DNA sequence. 14:109-21. (SCI)

  26. J. Zhu, Ching-Hao Teng, C. F. Chang, C. D. Chang, K. W. Simpson, C. Wei, P. McDonough, S. McDonough, and Y. F. Chang. (2002/12) Cloning and characterization of a Helicobacter bizzozeronii urease gene cluster. DNA sequence. 13:321-31. (SCI)

 
 B. 研討會論文 Conference Papers ( Selected Abstracts and Posters )
 a. 國際會議 International conference
  1. Yu-Ting Tseng, Ching-Hao Teng, and Kwang Sik Kim*. 2010/5. NlpI contributes to Escherichia coli K1 evasion of serum mediated killing by the classical complement pathway. The 110th general meeting, American Society for Microbiology. San Diego, USA.

  2. K. J. Kim, D. Goti, Ching-Hao Teng, T. Dam and K. S. Kim. 2005/5. Ezrin phosphorylation induced by cytotoxic necrotizing factor 1 mediates internalization of Escherichia coli K1 into human brain microvascular endothelial cells. The 105th general meeting, American Society for Microbiology. USA.

  3. Y. Xie, F. D. Cello, M. Paul-Satyaseela, G. Parthasarathy, Ching-Hao Teng and K. S. Kim. 2005/5. Expression profiles of E. coli RS218 during association with human brain microvascular endothelial cell (HBMEC). The 105th general meeting, American Society for Microbiology. USA.

  4. Ching-Hao Teng and K. S. Kim. 2004/5. Phase variation of type 1 fimbriae affects meningitis-causing E. coli K1 invasion of human brain microvascular endothelial cells. The 104th general meeting, American Society for Microbiology. USA.

  5. Ching-Hao Teng and Y. F. Chang. 2002/5. Cloning and characterization of an Ehrlichia canis gene encoding a protein localized to the morula membrane. The 102th general meeting, American Society for Microbiology. USA.

 
 b. 國內會議
  1. Masayuki Hashimoto, Chien-Shun Chiou, Ching-Hao Teng. 2014/8. Association between NotI-restriction resistance and pathogenicity in UTI E. coli. The 19th Annual  Conference on Bacteriology. Kaohsiung City, Taiwan.

  2. Po-Chuen Hsu, Wen-Chun Huang, Ching-Hao Teng, 2014/8. Identification of Prc's  substrates in Escherichia coli. The 19th Annual Conference on Bacteriology. Kaohsiung City, Taiwan.

  3. Masayuki Hashimoto, Chien-Shun Chiou, Ching-Hao Teng. 2013/12. Association between Escherichia coli with NotI-restriction resistance and urinary tract infections.  The 21th annual meeting of Taiwan Society of Microbiology. Taipei, Taiwan.

  4. Yi-Jyun Liao and Ching-Hao Teng. 2013/12. The role of type 1 fimbria in serum survival of pathogenic Escherichia coli. The 21th annual meeting of Taiwan Society of  Microbiology. Taipei, Taiwan.

  5. Yao-Yi Zang and Ching-Hao Teng. 2013/12. Identifying the roles of potentail sugar- metabolic genes of pathogenic Escherichia coli in urinary tract infections. The 21th  annual meeting of Taiwan Society of Microbiology. Taipei, Taiwan.

  6. Wen-Chu Huang and Ching-Hao Teng. 2012/8. Identification and characterization of the role of the Uropathogenic Escherichia coli gene rep in urinary tract infections. The 17th Annual Conference on Bacteriology. Nantou County, Taiwan.

  7. Fong-Ru Hsieh, Quan-Fu Chen, Ching-Hao Teng. 2012/8. The role of the eco60-62 operon in pathogenic Escherichia coli. The 17th Annual Conference on Bacteriology. Nantou County, Taiwan.

  8. Masayuki Hashimoto, Matsushima Hiroaki I Putu Suparthana, Ching-Hao Teng and Junichi Sekiguchi. 2012/8. d,l-endopeptidase activity at lateral cell wall is essential for Bacillus subtilis cell proliferation. The 17th Annual Conference on Bacteriology. Nantou County, Taiwan.

  9. Wen-Chu Huang and Ching-Hao Teng. 2011/12. Identification and characterization of the role of uropathogenic Escherichia coligene rep in urinary tract infections. The 20th general meeting, Taiwan Society of Microbiology. Tainan City, Taiwan.

  10. Chin-Ya Wang and Ching-Hao Teng. 2011/12. The role of Prc in Escherichia coli K1 evasion of serum killing. The 20th general meeting, Taiwan Society of Microbiology. Tainan City, Taiwan.

  11. Hsin Li and Ching-Hao Teng. 2011/8. Identification and Characterization of the Role of the eco293 island in uropathogenic Escherichia coli. The 16th Annual Conference on Bacteriology. Hualien City, Taiwan.

  12. Kuan-Fu Chen and Ching-Hao Teng. 2011/8. The Role of eco58 Operon in Pathogenetic Escherichia coli K1. The 16th Annual Conference on Bacteriology. Hualien City, Taiwan.

  13. Cheng-Wei Lu, Ching-Hao Teng, and Ying-Hsiang, Wang, 2010/8, Development of a diagnostic tool employing padlock probes to detect pathogenic Escherichia coli. The 15th Annual Conference on Bacteriology. Chiayi City, Taiwan.

  14. Chin-Ya Wang and Ching-Hao Teng*2010/8. The role of Prc in Escherichia coli K1 evasion of serum killing. The 15th Annual Conference on Bacteriology. Chiayi City, Taiwan.

  15. Yu-Ting Tseng and Ching-Hao Teng. 2009/8. Identifying and characterizing the role of nlpI gene of Escherichia coli K1 in serum resistance. The 14th Annual Conference on Bacteriology. Taiwan.

  16. Wen-Chung Huang and Ching-Hao Teng. 2008/8. Identification and characterization of the role of the eco294 gene of uropathogenic Escherichia coli in urinary tract infections. The 13th Annual Conference on Bacteriology. Taiwan.

  17. Chang-Chich Wei, Yuan-Man, Hsu, and Ching-Hao Teng. 2007/8. Development of diagnostic tools employing padlock probes and universal DNA array for multiplex detection of bacterial pathognes. The 12th Annual Conference on Bacteriology. Taiwan.

  18. Bin-Hsu Mao and Ching-Hao Teng. 2007/8. Identification of the potential virulence genes of uropathogenic Escherichia coli by microarray and PCR-based analyses. The 12th Annual Conference on Bacteriology. Taiwan.

 
 C. Books
  1. Ching-Hao Teng. Cloning and characterization of novel genes of Ehrlichia canis. 2002/1 Ph.D. Dissertation. Cornell University.
 
Grants
 
 A. 國科會
 

2013/08 ~ 2016/07

主持人,細菌 Prc 蛋白酶對於腸道外致病性大腸桿菌致病機轉之功能分析

 

2013/08 ~ 2016/07

子計畫主持人,(子計畫三)宿主基因WWOX在致病性大腸桿菌引起的泌尿道感染中的可能角色(1/3)。

 

2010/08 ~ 2013/07

主持人,"確認及分析與泌尿道感染相關連之大腸桿菌基因其可能的致病功能"

 

2011/08 ~ 2012/12

共同主持人,"構建大腸桿菌K1 蛋白質體晶片並用來發展研究人類細胞與病原菌蛋白質體交互作用之新型分析方法"

 

2007/08 ~ 2010/07

主持人,"確認及分析在 K1 大腸桿菌內type 1 fimbria K1 夾膜間的相互調控"

 

2006/08 ~ 2007/07

主持人,"確認並分析type 1 fimbriaOmpA NlpI 間的對話以及它們在K1 大腸桿菌與人類腦微血管內皮細胞互動時的貢獻"

 

2006/02 ~ 2006/07

主持人,"確認由大腸桿菌K1 的第一型fimbria 黏附蛋白(FimH)在人類腦微血管內皮細胞內引發的訊息傳遞"

 
 B. 其他來源計畫
 

2014/01 ~ 2015/12

子計畫#4主持人,"探討克雷伯肺炎菌感染反抗藥性的機轉與策略",成大醫院。

 

2013/01 ~ 2013/12

共同主持人,"與泌尿道感染相關的大腸桿菌可能醣類輸送基因之特性分析",成大醫院。

 

2012/01 ~ 2012/12

子計畫#4主持人,"人類致病性大腸桿菌抗藥性與致病因子相關性研究與其臨床應用性分析(二)",成大醫院。

 

2011/01 ~ 2011/12

子計畫#4主持人,"人類致病性大腸桿菌抗藥性與致病因子相關性研究與其臨床應用性分析(一)",成大醫院。

 

2010/09 ~ 2011/08

共同主持人,"以扣鎖探針建立初期的多重細菌性病原檢測平台",長庚紀念醫院。

 

2009/06 ~ 2010/05

共同主持人,"開發結合DNA環狀接合反應與DNA雜合技術之診斷工具應用於泌尿道致病性細菌檢測",長庚紀念醫院。

 

2007/08 ~ 2008/07

共同主持人," Functional genomic approach for discovery of molecular mechanisms and therapeutic",國立成功大學標竿計畫。

 

2007/01 ~ 2007/12

主持人,"結合扣鎖探針與DNA array技術發展多重人畜共通病原快速診斷系統",農委會防檢局。

 

2006/02 ~ 2006/12

主持人,"開發padlock probes 與universal DNA arrays結合技術用於診斷囓齒類動物細菌性傳染病原先導研究",國家實驗動物中心。

 

 

 

實驗室 4225

目前實驗室成員:

助理教授

橋本昌征

助理

陳揚青、陳皓文、王怡文

博士生

黃文俊

碩士生

許博淳、廖怡君、曾耀毅、謝鳳汝

 

 

 

畢業學生:

碩士班

 

96學年畢

魏彰志

97學年畢

毛彬旭

98學年畢

曾渝婷

99學年畢

王琴雅

101學年畢

陳冠福、李馨

 

 

實驗室花絮 

 

 

Lab Photo

 

 

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