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孫孝芳 H.Sunny Sun

SunnySun

孫孝芳教授(H.sunny Sun)

E-mail:hssun@mail.ncku.edu.tw

電話:06-2353535 分機3648

傳真:06-2095845

 

學經歷

 

學歷

1991/09~1996/02

美國威斯康辛大學遺傳學博士

 

1989/10~1991/05

University of California-Davis, 碩士

 

1984/09~1986/05

東海大學, 學士

   

 

現職 2016/08~ 國立成功大學醫學院分子醫學研究所所長
  1998/08~ 國立成功大學醫學院分子醫學研究所
 
 
經歷 1998/02~1998/07 私立中山醫學大學生命科學系
  1996/03~1998/01  Iowa State University-Animal Science
  1998/07~1989/08 台北榮總醫學研究部-免疫研究室

 

專長/研究興趣

 

基因體醫學, 分子遺傳學, 比較基因體學, 生物資訊

   

 

興趣:

1.新穎致癌基因TIAM2之功能研究及其致癌機制之探討。

TIAM2是一個非常新穎的基因但是相關的細胞內功能性分析報導仍付之厥如。我們的研究結果發現TIAM2是一個腦部特有的表現蛋白,而且僅表現在神經元細胞。重要的是87%肝癌組織都可檢測到異位性表現的TIAM2蛋白,因此TIAM2和癌症生成的確有顯著相關性。利用細胞及小鼠動物模式,證實了TIAM2大量表現不但增加細胞生長速率,TIAM2更會使低轉移性細胞株轉化成高侵入性轉移性細胞株。我們將利用基因轉殖鼠來進一步探討TIAM2之功能及其致癌機制。

2.血清素傳遞系統失常在躁鬱症致病機制上的分子遺傳研究。

本實驗室先前一系列的研證實血清素傳遞系統基因在躁鬱症的發生上扮演相當重要的角色。目前的主題是利用神經細胞的模式來探討在血清素傳遞系統失常的情形下,細胞內整體的調控及平衡機制,藉以瞭解躁鬱症的發生機轉。

3.人類第九纖維母細胞生長因子基因表現之調控機制。

人類第九纖維母細胞生長因子(FGF9)是一個高度保留在各個物種且具有促進多種細胞生長的基因。研究顯示FGF9在胚胎發育、器官形成、性別發展和維持生命機能上可能扮演重要角色。本實驗室的主題是探討FGF9基因表現再各層級之調控機制及其在性別發育上所扮演角色。
4生物資訊學。

本實驗室希望有系統的朝向生物資訊學教育推廣、研究發展、及服務等方面努力。目前的研究方向是研究基因體的結構性多行性(CNV)分佈及其在人類疾病的影響、及發展癌症基因體醫學相關之資料庫(TAG)等。

 

  方向:

1. 精神/神經疾病的致病基因定位

2. 生物資訊工具的開發與利用

3. 癌化過程分子機制的探討

4. 癌症基因定位

5. 基因體醫學研究

研究成果 (Publications) -- H. Sunny Sun

 
期刊論文 Refereed Papers
  1. Shin HC, Kang TW, Wu YH, Sun HS, Tseng CA. Validation of simplified postoperative nausea and vomiting intensity scale in Taiwan.J Clin Monit Comput. 2018 Oct;32(5):937-944. doi: 10.1007/s10877-017-0084-1. Epub 2017 Dec 1.

  2. Yusuf IO, Chen HM, Cheng PH, Chang CY, Tsai SJ, Chuang JI, Wu CC, Huang BM, Sun HS, Yang SH. Fibroblast growth factor 9 activates anti-oxidative functions of Nrf2 through ERK signalling in striatal cell models of Huntington's disease.Free Radic Biol Med. 2018 Nov 2;130:256-266. doi: 10.1016/j.freeradbiomed.2018.10.455. [Epub ahead of print]

  3. Chang MM, Lai MS, Hong SY, Pan BS, Huang H, Yang SH, Wu CC, Sun HS, Chuang JI, Wang CY, Huang BM. FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells.Cancer Sci. 2018 Nov;109(11):3503-3518. doi: 10.1111/cas.13793. Epub 2018 Oct 23.

  4. Yusuf IO, Cheng PH, Chen HM, Chang YF, Chang CY, Yang HI, Lin CW, Tsai SJ, Chuang JI, Wu CC, Huang BM, Sun HS, Yang SH. Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's DiseaseCell Physiol Biochem. 2018;48(2):605-617. doi: 10.1159/000491889. Epub 2018 Jul 18.

  5. Joseph NA, Chiou SH, Lung Z, Yang CL, Lin TY, Chang HW, Sun HS, Gupta SK, Yen L, Wang SD, Chow KC. The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells.J Hematol Oncol. 2018 May 31;11(1):74. doi: 10.1186/s13045-018-0557-9.

  6. Lin YJ, Hsin IL, Sun HS, Lin S, Lai YL, Chen HY, Chen TY, Chen YP, Shen YT, Wu HM. NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation.Mol Neurobiol. 2018 Nov;55(11):8403-8413. doi: 10.1007/s12035-018-0995-y. Epub 2018 Mar 16.

  7. Lee YH, Hsueh YW, Peng YH, Chang KC, Tsai KJ, Sun HS, Su IJ, Chiang PM., Hung WC. (2017 Mar 21) Low-cell-number, single-tube amplification (STA) of total RNA revealed transcriptome changes from pluripotency to endothelium.BMC Biol.15(1):22, Impact factor 6.779, Ranking 5.95%

  8. Lee YH, Hsueh YW, Peng YH, Chang KC, Tsai KJ, Sun HS, Su IJ, Chiang PM., Hung WC. (2017 Mar 21) Low-cell-number, single-tube amplification (STA) of total RNA revealed transcriptome changes from pluripotency to endothelium.BMC Biol.15(1):22, Impact factor 6.779, Ranking 5.95%

  9. Hsiao KY, Lin YC, Gupta SK, Chang N, Yen L, Sun HS, Tsai SJ. (2017 Mar 1) Non-coding effects of circular RNA CCDC66 promote colon cancer growth and metastasis.Cancer Res.77(9):2339-2350, Impact factor 9.122, Ranking 6.91%

  10. Hsiao KY, Sun HS, Tsai SJ. (2017 Jun) Circular RNA - New member of noncoding RNA with novel functions.Exp Biol Med (Maywood). 242(11):1136-1141, Impact factor 2.803, Ranking 46.09%

  11. Chen JY, Lai YS, Tsai HJ, Kuo CC, Yen BL, Yeh SP, Sun HS, Hung WC. (2016) The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells.Sci Rep.6:32428, Impact factor 5.228, Ranking 7/63 (11.1%)

  12. Hung IC, Hsiao YC, Sun HS, Chen TM, Lee SJ. (2016) MicroRNAs regulate gene plasticity during cold shock in zebrafish larvae.BMC Genomics. 17(1), Impact factor 3.867, Ranking 32/161 (19.9%)

  13. Wei-Hsuan Yen, Wu-Sian Ke, Jan-Jong Hung, Tsung-Ming Chen, Jia-Shing Chen, H. Sunny Sun* (2016 Jan. 14) Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma Cancer Medicine. 5(3):465-77, Impact factor 2.915, Ranking 107/213 (50.2%)

  14. Huang SM, Liao WT, Lin CF, Sun HS, Chow NH (2016 Mar.) Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves' Disease World J Surg.40(3):505-9, Impact factor 2.523, Ranking 52/199 (26.1%)

  15. Lai MC, Sun HS Wang SW, Tarn WY (2015 Oct. 31) DDX3 functions in antiviral innate immunity through translational control of PACT "FEBS J. ISSN: 1742-464X"283(1):88-101, Impact factor 4.237, Ranking 72/289 (24.9%)

  16. Lai MS, Wang CY, Yang SH, Wu CC, Sun HS, Tsai SJ, Chuang JI, Chen YC, Huang BM. (2016 Apr. 2) The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis12(2):61-77, Impact factor 2.91, Ranking 15/76 (19.7%)

  17. Lai MC, Chang CM, Sun HS. (2016 Apr. 14) Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells. PLoS One.11(4):e0153627, Impact factor 3.057, Ranking 11/63 (17.5%)

  18. Lai WC, Sun HS, Lin PH, Lin H, Shieh JC (2016 Feb.) A new rapid and efficient system with dominant selection developed to inactivate and conditionally express genes in Candida albicans. Current Genetics62(1):213-35, Impact factor 3.385, Ranking 54/165 (32.7%)

  19. Chun-Wei Chien, Pei-Chi Hou, Han-Chung Wu, Yu-Ling Chang, Shih-Chieh Lin, Shau-Chieh Lin, Bo-Wen Lin, Jenq-Chang Lee, Yu-Jia Chang, and H. Sunny Sun* (2016 May. 2) Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer Oncogene [Epub ahead of print], Impact factor 7.932, Ranking 15/213 (7.0%)

  20. Shih HI, Wang HC, Su IJ, Hsu HC, Wang JR, Sun HF(孫孝芳), Chou CH, Ko WC, Hsieh MI, Wu CJ. (2015) Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012-2013: A PCR/Electrospray Ionization Mass Spectrometry Study. Medicine (Baltimore).94(38).e1545.

  21. Huang SM, Liao WT, Lin CF, Sun HS(孫孝芳), Chow NH.(2015)Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves' Disease.World J Surg

  22. Chuang JI, Huang JY, Tsai SJ, Sun HS(孫孝芳), Yang SH, Chuang PC, Huang BM, Ching CH. FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation.Free Radic Biol Med.89.274-86

  23. Liu YC, Wang SC, Yu YJ, Fung KM, Yang MT, Tseng YH, Tsai SF, Sun HS(孫孝芳), Lyu PC, Chou SH. (2015)Complete Genome Sequence of Xanthomonas campestris pv. campestris Strain 17 from Taiwan. Genome Announc.3(6). pii: e01466-15. doi: 10.1128/genomeA.01466-15.

  24. Lai MC, Sun HS(孫孝芳) ,Wang SW(王憲威), Tarn WY.(2015) DDX3 functions in antiviral innate immunity through translational control of PACT.FEBS J. doi: 10.1111/febs.13553.

  25. Wang HC, Cheng FC, Wu MS, Shu HY, Sun HS, Wang YC, Su IJ, Wu CJ. (2015) Genome Sequences of Three Helicobacter pylori Strains from Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma. Genome Announc. 3(2):pii:e00229-15. doi: 10.1128/genomeA.00229-15.

  26. Chang JY, Lee MH, Lin SR, Yang LY, Sun HS, Sze CI, Hong Q, Lin YS, Chou YT, Hsu LJ, Jan MS, Gong CX, Chang NS. (2015) Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain. Oncotarget. 6(6):3578-89.

  27. Liang KC, Tseng JT, Tsai SJ, Sun HS. (2015) Characterization and distribution of repetitive elements in association with genes in the human genome. Comput Biol Chem. pii: S1476-9271(15)00024-9.

  28. Tang YA, Chen CH, Sun HS, Cheng CP, Tseng VS, Hsu HS, Su WC, Lai WW, Wang YC. (2015) Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer. Nucleic Acids Res.43(3):1593-60.

  29. Yu-Tzu Chang, Ming-Cheng Wang, An-Bang Wu, Junne-Ming Sung, H. Sunny Sun, Ih-Jen Su, Wei-ChihKan, Chih- Chiang Chien, Jyh-Chang Hwang, Hsien-Yi Wang, Chin-Chung Tseng, and Chi-Jung Wu. (2014) Rapid Identification of Bacteria and Candida Pathogens in Peritoneal Dialysis Effluent from Patients with Peritoneal Dialysis-Related Peritonitis Using Multilocus PCR Coupled with Electrospray Ionization Mass Spectrometry. J ClinMicrobiol. 52(4):1217-1219.

  30. Kuo PH, Chuang LC, Liu JR, Liu CM, Huang MC, Lin SK, Sun HS, Hsieh MH, Hung H, Lu RB. (2014) Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study. Neuro-Psychopharmacology &Biological Psychiatry. 51:58-64.

  31. Wen-Chi Jan, Shi-Yi Yang, Li-Chung Chuang, Ru-Band Lu, Ming-Kun Lu, H. S. Sun,Po-HsiuKuo. (2014) Exploring the associations between genetic variants in genes encoding for subunits of calcium channel and subtypes of bipolar disorder. JAffect Disord. 20(157) :80-86.

  32. Chi-Jung Wu, M.D.; Ya-Pin Chen; Hsuan-Chen Wang; Ih-Jen Su; Wen-ChienKo; Jiann-Shiuh Chen; Chao-Neng Cheng;Nan-Yao Lee; H. Sunny Sun; Chia-Yu Chi; Tsai-Yun Chen. (2014) Identification of Fungal Pathogens from Clinical Specimens using Multi-locus PCR Coupled with Electrospray Ionization Mass Spectrometry. Diagnostic Microbiology and Infectious Disease DiagnMicrobiol Infect. 78(2):141-143.

  33. Wan-Lin Liao, Shao-Chieh Lin, H. Sunny Sun*, Shaw-Jenq Tsai*. (2014) Hypoxia-induced tumor malignancy and drug resistance: Role of microRNAs. Biomarkers and Genomic Medicine. 6 :1-11.

  34. Tsung-Ming Chen, Yu-Heng Shih, Joseph T. Tseng, Chih-Hao Wu, Yi-Han Lee, Shaw-Jenq Tsai*, and H. Sunny Sun*. (2014) Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic acids research. 42(5):2932-44.

  35. Ya-Chi Lin, Joseph T. Tseng, Shuen-Lin Jeng and H. Sunny Sun*. (2014) Comprehensive analysis of common coding sequence variants in Taiwanese Han population. Biomarkers and Genomic Medicine. 6 :133-143

  36. Yi-Mei Joy Lin, Cheng-Da Hsu, Hsiao-Yen Hsieh, Chia-Chih Alex Tseng, H. Sunny Sun*. (2014) Sequence Variants of HTR3A Gene Contribute to Genetic Prediction of Postoperative Nausea in Taiwan. (submitted).

  37. Ying-Ju Yang, Yi-Mei J. Lin and H. Sunny Sun*. (2014) Dynamic Regulation of Serotonin Biosynthesis in Disturbed Serotonergic Neurons. (In preparation).

  38. Chung CL, Lu CW, Cheng YS, Lin CY, Sun HS*, Lin YM*. (2013) Association of aberrant expression of sex-determining gene fibroblast growth factor 9 with Sertoli cell-only syndrome. Fertility and Sterility. 100(6):1547-1554.

  39. Su MT, Liang YL, Chen JC, Sun HS, Chang FM, Kuo PL. (2013) Non-mosaic uniparental trisomy 16 presenting with asplenia syndrome and placental abruption: a case report and literature review. European journal of medical genetics. 56(4):197-201.

  40. Chi-Jung Wu, Hsuan-Chen Wang, Po-Lin Chen, Ming-Chung Chang, H. Sunny Sun, Pei-Hsin Chou, Wen-Chien. (2013) AQU-1, a chromosomal class C b-lactamase, among clinical Aeromonas dhakensis isolates: Distribution and clinical significance. International Journal of Antimicrobial Agents. Int J Antimicrob Agents. 42(5):456-461.

  41. Ming-Chih Lai, Shainn-Wei Wang, Lie Cheng,Woan-Yuh Tarn, Shaw-Jenq Tsai* and H. Sunny Sun*. (2013) Human DDX3 Interacts with the HIV-1 Tat Protein to Facilitate Viral mRNA Translation. PLoS ONE. 8(7):e68665.

  42. Chiu HC, Chow KC, Fan YH, Chang SC, Chiou SH*, Chiang SF, Chiou CH, Wu GH, Yang HC, Ho SP, Chen YK, Lee WC, Sun HS. (2013) Expression of EBV-encoded oncogenes and EBV-like virions in multiple canine tumors. Veterinary microbiology. 163(1-2) :79-89

  43. Jia-Shing Chen; Wei-Shiang Hung; Hsiang-Han Chan; Shaw-Jenq Tsai; H. Sunny Sun*. (2013) In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics. 29(4): 420-7.

  44. H.P. Su, C.J. Hou, W.H. Chen, K.J. Wang, Y.H. Chiu, H.S. Sun.* (2013) A miniature lighted stylet for fast oral endotracheal intubation in rabbits. The Veterinary Journal. 195(2): 254-6.

  45. Lin MW, Tsai SJ, Chou PY, Huang MF, Sun HS, Wu MH. (2012) Vitamin D receptor 1a promotor -1521 G/C and -1012 A/G polymorphisms in polycystic ovary syndrome. Taiwan J Obstet Gynecol. 51(4):565-71

  46. Jia–Shing Chen, Ih-Jen Su, Yu-Wei Leu, Kung-Chia Young, H. Sunny Sun*. (2012-Mar) Expression of T-Cell Lymphoma Invasion and Metastasis 2 Promotes Proliferation and Invasion in liver cancer. INTERNATIONAL JOURNAL OF CANCER. 130(6), 1302-13.

  47. Yu-Chen Jiang, Hung-Ming Wu, Kai-Hsin Cheng and H. Sunny Sun*. (2012) Menstrual Cycle-dependent Febrile Episode Mediated by Sequence-specific Repression of Poly(ADP-ribose) Polymerase-1 on the Transcription of the Human Serotonin Receptor 1A Gene. Human Mutation. 33 (1) :209-17.

  48. Wen Teng, Pei-Chi Hou, Kuan-Der Lee, Pei-Yi Chu, Kun-Tu Yeh, Victor Jin, Min-Jen Tseng, Shaw-Jenq Tsai, Yu-Sun Chang, Chi-Sheng Wu, H. Sunny Sun, Kuen-daw Tsai, Long-Bin Jeng, Kenneth Nephew, Tim Huang, Shu-Huei Hsiao, and Yu-Wei Leu. (2011) Targeted Methlation of Two Tumor Suppressor Genes Is Sufficient to Transform Mesenchymal Stem Cells into Cancer Stem/Initiating Cells. Cancer Research. 71(13); 4653- 4663.

  49. Chia-Chen Hsu, Yu-Wei Leu, Min-Jen Tseng, Kuan-Der Lee, Tzen-Yu Kuo, Jia-Yi Yen, Yen-Ling Lai, Yi-Chen Hung, Wei-Sheng Sun, Pei-Yi Chu, Chien-Min Chen, Kun-Tu Yeh, Pearlly S. Yan, H. Sunny Sun, Yu-Sun Chang, Tim H.-M. Huang, and Shu-Huei Hsiao (2011) Functional characterization of Trip10 in cancer cell growth and survival. Journal of Biomedical Science. 18:12.

  50. Ying-Fan Chen, Chao-Ling Tung, Wen-Chi Hsiao, Yao Chang, lh-Jen Su and H. Sunny Sun*. (2011) Analysis of global methylation using a Zta­expressing nasopharyngeal carcinoma cell line. Genomics. 97(4):205-13.

  51. San-Yuan Huang, Jyh-Hung Lin, Shih-HuaTeng, H. Sunny Sun, Yu-Hui Chen, Meng-Ting Chung, Chin-kai Chuang, En-Chung Lin, and Mu-Chiou Huang. (2011) Differential expression of porcine testis proteins during postnatal development.Animal Reproduction Science. 123(3-4):221-33.

  52. Bing-Huang Gau, Tsung-Ming Chen, Yu-Herg J. Shih, and H. Sunny Sun*. (2011) FUBP3 interacts with FGF9 3' microsatellite and positively regulates FGF9 translation. Nucleic Acids Res. 39(9):3582-93.

  53. Tsung-Ming Chen, Chien-Hui Hsu, Shaw-Jenq Tsai, and H. Sunny Sun*. (2010) AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay. Nucleic Acids Res. 38(22):8061-8071.

  54. Shu-Huei Hsiao; Kuan-Der Lee; Chia-Chen Hsu; Min-Jen Tseng; Victor Jin; Wei-Sheng Sun; Yi-Chen Hung; Kun-TuYeh; Pearlly Yan; Yen-Yu Lai; H. Sunny Sun; Yen-Jung Lu; Yu-Sun Chang; Shaw-Jenq Tsai; Tim Huang, and Yu-Wei Leu. (2010) DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. BiochemBiophys Res Commun. 24:400(3):305-12.

  55. Tzu-Ling Tseng, Wei-Chung Lai, Ting Jian, Chuan Li, Hsiao-Fang S. Sun, Tzong-Der Way, Jia-ChingShieh, (2010) Affinity purification of Candida albicans CaCdc4-associated proteins reveals the presence of novel proteins involved in morphogenesis. BiochemBiophys Res Commun. 23:395(1):152-7.

  56. Lin YM, Tsai CC, Chung CL, Chen PR, Sunny Sun H, Tsai SJ, Huang BM. (2010) Fibroblast growth factor 9 stimulates steroidogenesis in postnatal Leydig cells. Int J Androl. 33(3):545-53.

  57. Shin-Chih Chao, Jia–ShingChen, Cheng-Hsien Tsai, Joy Yi-Mei Lin, Yuh-Jyh Lin, and H. Sunny Sun*. (2010) Novel exon nucleotide substitution at the splice junction causes a neonatal Marfan syndrome. Clinical Genetics. 77(5):453-463.

  58. Lin, Yi-Mei J., Huei-Chen Ko, Fong-Ming Chang, Tzung-LiehYeh, and H. Sunny Sun*. (2009) Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. Arch Womens Ment Health. 12(6):401–408.

 

B. 研討會論文 Conference papers

  1. H. Sunny Sun. 2014. Profile of common coding variants in Taiwanese Han population, NGS Asia Congress, 7-8 October 2014, Singapore.

  2. Ya-Chi Lin, Joseph T. Tseng, H. Sunny Sun. Integrated analyses of copy number variation and differential gene expression in colorectal cancers, NGS Asia Congress, 7-8 October 2014, Singapore.

  3. H. Sunny Sun. 2014. From bench to the bed-site: Molecular Targeting of Serotonin imbalance-Mediated disorders, Personalized Medicine and Big Data Symposium Aug. 3-4, 2014, Tainan.

  4. Yu-Chuan Wu, Tsung-Ming Chen, Joseph T. Tseng, H. Sunny Sun. Study the mechanism of HuR-mediated regulation on FGF9 expression under hypoxia. 2014. The 29th Joint Annual Conference of Biomedical Sciences, March 15-16, 2014. Taipei, Taiwan.

  5. Wei-Hsuan Yen, Jan-Jong Hung, Tsung-Ming Chen, Jia-Shing Chen, Wu-Sian Ke, H. Sunny Sun. The regulatory mechanism of SP1 on T-cell lymphoma Invasion and Metastasis 2 (TIAM2) expression in Hepatocellular Carcinoma. 2014. The 29th Joint Annual Conference of Biomedical Sciences, March 15-16, 2014. Taipei, Taiwan.

  6. Ya-Chi Lin; Joseph T. Tseng; Shuen-Lin Jeng; and H. Sunny Sun. A comprehensive analysis of common coding sequence variants in Taiwanese Han population. 2014. HGM 2014 conference, April 27 – 30, 2014; Geneva, Switzerland.

  7. Ya-Chi Lin; Joseph T. Tseng; Shuen-Lin Jeng; and H. Sunny Sun. Survey of Common Coding Copy Number Variation in Taiwanese Han Population. 2014. Molecular Med Tri-Con 2014, Feb. 9 -14, 2014. Moscone North Convention Center, San Francisco, USA.

  8. Ming-Chih Lai, Shaw-Jenq Tsai and H. Sunny Sun. 2013. Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. The 18th Annual Meeting of the RNA Society; June 11-16, 2013; Davos, Switzerland.

  9. Ya-Chi Lin; Joseph T. Tseng; Shuen-Lin Jeng; and H. Sunny Sun. A Survey of common coding sequence variation in Taiwanese Han population. The Joint Conference of HGM 2013 and 21st International Congress of Genetics, April 13 – 18, 2013; Singapore.

  10. ChihHao Wu, Ming Chih Lai, Tsung Ming Chen, H. Sunny Sun. Identification of IRES trans-acting factors (ITAFs) involved in the hypoxia-induced translational up-regulation of FGF9 protein expression. 2013. The 28th Joint Annual Conference of Biomedical Sciences (poster award)

  11. Hsiao YC*, Chen TM*, Sun HS and Lee SJ. The regulatory role of microRNAs in cold shock using Zebrafish as model. 2013 The Twenty-first Symposium on Recent Advances in Cellular and Molecular Biology Kenting.

  12. Ming-Chih Lai, Shaw-Jenq Tsai and H. Sunny Sun. 2012. Characterization of translational regulation during hypoxia in human colon cancer HCT116 cells. The 17th Annual Meeting of the RNA Society; May 29-June 2, 2012; Ann Arbor, Michigan, USA.

  13. Chen TM*, Hsiao YC*, Sun HS and Lee SJ. Changes of microRNA profiles upon cold shock in zebrafish. 2012 The Fisheries Society of Taiwan, p13. (Oral presentation).

  14. Jia-Shing Chen, Wei-Shine Hong, Hsiang-Han Chan, Shaw-Jenq Tsai, and H. Sunny Sun. In silico identification of oncogenic potential of FRK in hepatocellular carcinoma. Bio-IT World Conference & Expo ‘12. April 24-26, 2012. Boston, MA, USA

  15. Ming-Chih Lai, Shaw-Jenq Tsai and H. Sunny Sun. 2012. Characterization of translational regulation during hypoxia in human colon cancer. Twentieth Symposium on Recent Advances in Cellular and Molecular Biology; Feb 7-9, 2012; Taiwan.

  16. Ke WS, Chen JS, and Sun HS. Study the mechanism of ectopic expression of T-Cell Lymphoma Invasion and Metastasis 2 in Hepatocellular Carcinoma,Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology. Feb 10-12, 2011.

  17. Ming-Chih Lai, Shaw-sai and H. Sunny Sun. 2011. Characterization of translational regulation during hypoxia in human colon cancer. The 16th Annual Meeting of the RNA Society; Jun 14-18, 2011; Kyoto, Japan.

  18. Chen JS, Sun HS. 2011. Identification and functional characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2) in neuronal cells. Program and Abstract book of the 102nd annual meeting of AACR: P1885. May 2-5, 2011. Olando, Florida, USA.

  19. Chen JS, Hong WS, Chan HH, Tsai SJ, and Sun HS. 2010.Tumor-Associated Gene (TAG): a comprehensive database for cancer research. The 2010 Systems Biology and Bioinformatics Symposium (SBBS), November 4-6, 2010. Hsinchu, Taiwan.

  20. Clément Mettling, Shaw-Jenq Tsai, and H. Sunny Sun. 2010. High-resolution genome-wide analysis of copy number variation in colorectal cancer. XGen Congress: Applying next generation genomic technologies for now generation discoveries. March 15-19, 2010, San Diego, USA.

  21. Yu-Chen Jiang , Kai-Hsin Cheng and H. Sunny Sun. 2010, Functional Characterization of the -480delA Mutation of Human Serotonin Receptor 1A Gene. ACGA Conference 2010, Taipei

  22. Wei-ShiangHung , Hsiang-Han Chan, H. Sunny Sun. 2010. Identification and Characterization of Novel Tumor-Associated Genes in Liver Cancer. ACGA Conference 2010, Taipei

  23. Chiao-May Chang, En-Chung Lin, Winston TK Cheng, Shaw-Jenq Tsai, H. Sunny Sun .2010.Computational prediction of human microRNA homologs in the porcine genome, RNA 2010 Symposium, p62

  24. Tsung-ming Chen, Chien-hui Hsu, Shaw-Jenq Tsai, H. Sunny Sun .2010.AUF1 isoform specifically binds to the 3’ UTR of human fibroblast growth factor 9 (FGF9) gene and controls FGF9 mRNA decay, RNA 2010 Symposium, p59

  25. Bing-Huang Gau, Tsung-Ming Chen and H. Sunny Sun. 2010.Far upstream element-binding protein 3 (FUBP3) positively regulates FGF9 expression through the (UG) dinucleotide repeats on FGF9 3’-untranslated region RNA 2010 Symposium, p49

  26. HS Sun. 2009. Bioinformatic tools for medical research International Workshop of virtual Asian Bioinformation Center (ABC), April 2 – 5, 2009, Seoul, Korea

  27. Tsung-ming Chen, Chien-hui Hsu, Shaw-Jenq Tsai, H.Sunny Sun.2009.FGF9 expression is controlled by AUF1-medicated degradation in prostaglandin E2-treated stromal cell. RNA 2009 Symposium, p76.

  28. Yu-Heng Shih, Tsung-Ming Chen, Shao-Cheng Tsai, H.Sunny Sun.2009.Hypoxia induced translational enhancement of human FGF9 expression is mediated by the IRES of FGF9 5'UTR. RNA 2009 Symposium, p.75

  29. Bing-Huang Gau, Tsung-Ming Chen, H.Sunny Sun.2009.FGF9 expression is modulated by 3'-UTR (UG)15 repeat and RNA binding protein FUBP3. RNA 2009 Symposium, p.74

  30. Chiao-May Chang, En-Chung Lin, Winston TK Cheng, Shaw-Jenq Tsai, H.Sunny Sun.2009.Computational identification of microRNA for porcine embryos. RNA 2009 Symposium, p.73

  31. Shih, YH, Chen, TM, and H. Sunny Sun. 2008. The translational regulation of human FGF9 5’UTR on FGF9 protein expression. RNA 2008 Symposium, p58.

  32. Chen, TM, CH Hsu, and H. Sunny Sun. 2008. FGF9 mRNA stability is controlled by AUF1 medicated AU-rich element degradation pathway. RNA 2008 Symposium, p57.

  33. Chen, TM, CH Hsu, and H. Sunny Sun. 2008. AUF-1 binds to the 3’ untranslated region of human Fibroblast growth factor 9 (FGF9) gene and facilitates FGF9 mRNA decay. RNA 2008 Symposium, p14.
     

C. 專書及專書研討會論文 Books

1. Sun, H. S. 2000. From Mighty mouse to Schwarzenegger cattle—study and application of comparative genomics. 2000. Feed
    Manufacturing Technology Short Course Proceedings: p36-42.

 

D. 技術報告及其它 Presentations (including exhibitions)

  1. EB病毒感染在引發宿主基因體改變及癌症易感性之影響 (94年05月~97年04月)

  2. 利用生物資訊方法搜尋基因體中受缺氧誘導因子調控之基因並研究其功能(95年05月~97年04月)

  3. 血清素傳遞系統整合調控在躁鬱症病理成因的分子機制探討(97年05月~100年04月)

  4. 基因體醫學及生技研發之生物資訊核心設施--(子計畫五)應用醫學基因體(97年05月~100年04月)

  5. 微核糖核酸-136及微核糖核酸-630在男性不孕症患者睾丸中所扮演的角色(99年08月~102年07月)

  6. 探討大腸癌細胞在缺氧環境下所進行的轉譯調控(99年08月~100年07月)

  7. 台灣生物資訊核心設施I-台灣生物資訊核心設施總計畫及子計畫一:統計遺傳I (100年05月~101年04)

  8. 癌細胞基因體重編程之探討-蛋白質轉譯改變對基因體重編程之影響(總計畫及子計畫3) (100年08月~103年07)

  9. 台灣生物資訊核心設施II(101年05月~102年04)

  10. 探討在發育和疾病過程中纖維母細胞生長因子9所扮演的角色-(子計畫一)研究第九號纖維母細胞生長因子在雄性性腺發育所扮演的角色 (101年08月~103年07月)

  11. 台灣生物資訊核心設施III(102年05月~103年04)

實驗室 3645

 

 

目前實驗室成員:

專案助理教授

賴銘志

博士後研究員

林雅琪、陳琮明

助理

吳香樺、陳立臻、張喬玟、陳婉平、邱暉煜、黃瑞琪、徐子傑

博士生

李亦漢、裴武明皇

碩士生

詹雅玲、江鈺婷、顏薇軒、巫毓娟、許舒婷

 

 

 

畢業學生:

博士班

 

95

林宜玟

98

陳琮明、陳嘉興

 

 

碩士班

 

89

吳佳燕

90

林雅琪、王惠君

91

林舒敏

92

高國勝、陳琮明

93

趙新志、徐千惠

94

詹湘漢、蕭汶淇

95

董昭伶

96

王雅筠

97

楊英如

98

姜俞臣、洪偉翔

100

柯武賢

101

吳致豪

 

 

 

實驗室花絮

   
 

 

 

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