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IMM faculty Recruitment


Hsiang-fu Kung,Ph.D

Molecular targets for liver cancer and treatment with Traditional Chinese Medicine


Time: 12:30PM~14:00PM

Date: June 23, 2011 (Thursday)

Location: Fourth Lecture,Med College Building


First Taiwanese Recipient of SEBM Distinguished Scientist Award

Article of the month
Subject Category: Neuroscience
Citation: Cell Death and Disease (2010) 1, e110;
Published online 23 December 2010
  TGF-β induces TIAF1 self-aggregation via type II receptorindependent signaling that leads to generation of amyloid β plaques in Alzheimer's disease


蔣輯武老師                                              New 2015.12

The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetesAkt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1. . doi: 10.18632/oncotarget.6609. (2015 Dec)

The B56γ-containing protein phosphatase 2A (PP2A-B56γ) has been postulated to have tumor suppressive functions. Here, we report regulation of p27KIP1 subcellular localization by PP2A-B56γ3. B56γ3 overexpression enhanced nuclear localization of p27KIP1, whereas knockdown of B56γ3 decreased p27KIP1 nuclear localization. B56γ3 overexpression decreased phosphorylation at Thr157 (phospho-Thr157), whose phosphorylation promotes cytoplasmic localization of p27KIP1, whereas B56γ3 knockdown significantly increased the level of phospho-Thr157. In vitro, PP2A-B56γ3 catalyzed dephosphorylation of phospho-Thr157 in a dose-dependent and okadaic acid-sensitive manner. B56γ3 did not increase p27KIP1 nuclear localization by down-regulating the upstream kinase Akt activity and outcompeted a myristoylated constitutively active Akt (Aktca) in regulating Thr157 phosphorylation and subcellular localization of p27KIP1. In addition, ............ 接續

吳梨華老師                                              New 2015.03

A gp130-Src-YAP module links intestinal injury and inflammation to epithelial regeneration . Nature, 519:57-62 (2015 Mar)

PInflammation is a complex biological response triggered by tissue damage or microbial invasion. In addition to host defence, self-limiting inflammation triggers regeneration and repair12. By preventing further microbial translocation, healing promotes resolution of inflammation. Whereas host defence and immunity have been extensively studied, the mechanisms by which inflammation stimulates regenerative responses remain obscure. Numerous pathways involved in tissue growth, patterning and differentiation are re-deployed during regeneration, including the Hedgehog (Hh)–Gli, Wnt–β-catenin, Notch and Hippo–YAP pathways34. Upon tissue injury, myeloid cells, including macrophages, produce inflammatory cytokines and growth factors5. However, signalling mechanisms that link typical inflammatory cytokines to pivotal transcriptional regulators of tissue growth, repair and regeneration remain to be charted............ 接續


蔣輯武老師                                              New 2015.01.15

Visualization of subunit interactions and ternary complexes of protein phosphatase 2A in mammalian cells. (2014) PLoS One, 9(12): e116074

Protein phosphatase 2A (PP2A) is a ubiquitous phospho-serine/threonine phosphatase that controls many diverse cellular functions. The predominant form of PP2A is a heterotrimeric holoenzyme consisting of a scaffolding A subunit, a variable regulatory B subunit, and a catalytic C subunit. The C subunit also associates with other interacting partners, such as α4, to form non-canonical PP2A complexes. We report visualization of PP2A complexes in mammalian cells. Bimolecular fluorescence complementation (BiFC) analysis of PP2A subunit interactions demonstrates that the B subunit plays a key role in directing the subcellular localization of PP2A, and confirms that the A subunit functions as a scaffold in recruiting the B and C subunits to form a heterotrimeric holoenzyme. 。........... 接續

H.Sunny Sun, Ph.D.

Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation.Nucleic acids research. 42(5):2932-44.

Human fibroblast growth factor 9 (FGF9) is a potent mitogen involved in many physiological processes. Although FGF9 mRNA is ubiquitously expressed in embryos, FGF9 protein expression is generally low and restricted to a few adult organs. Aberrant expression of FGF9 usually results in human malignancies including cancers, but the mechanism remains largely unknown. Here, we report that FGF9 protein, but not mRNA, was increased in hypoxia. .......... More

Christina Ling Chang, Ph.D.
A dual-fluorescent reporter facilitates identification of thiol compounds that suppress microsatellite instability induced by oxidative stress. Free Radical Biology and Medicine. 2014 April; 69:86–95.

Patients with chronic inflammation or inflammation-associated cancer display microsatellite instability (MSI), indicating a possible inactivation of DNA mismatch repair (MMR). We previously reported that H2O2-generated oxidative stress inactivates the MMR function and increases mutation accumulation in a reporter microsatellite.  ........... More



Chi-Wu Chiang, Ph.D. 、 Ting-Tsung Chang, M.D.
Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma. (2012) PLoS One. 2012;7(7):e41931.

Hepatocellular carcinoma (HCC), a major cause of cancer-related death in Southeast Asia, is frequently associated with hepatitis B virus (HBV) infection. HBV X protein (HBx), encoded by a viral non-structural gene, is a multifunctional regulator in HBV-associated tumor development. We investigated novel signaling pathways underlying HBx-induced liver tumorigenesis and found that  ........... More



Nan-Shan Chang, Ph.D.
1) TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death(2012). Cell Death &Disease, 3, e302;

2) Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas(2013).  Front. Oncol.3:43.

3) Assessing current therapeutic approaches to decode potential resistance mechanisms in glioblastomas(2013). Front. Oncol. 3:59.

4) Self-aggregating TIAF1 in lung cance progression(2013). Translational Respiratory Medicine1:5.

TIAF1 protein is frequently expressed in the proliferating GBM cells, probably due to the stimulation of micro-environmental factors in the brain. The intracellular TIAF1 undergoes self-aggregation, may induce caspase activation, and leads to phosphorylation and degradation of membrane amyloid precursor protein  ........... More


Shainn-Wei Wang, Ph.D.
An integrated chip capable of performing sample pretreatment and nucleic acid amplification for HIV-1 detection. Biosensors and Bioelectronics. Accepted. 2012 Sep 27. BIOS-D-12-01947R1, pii: S0956-5663(12)00617-3. doi: 10.1016/j.bios.2012.09.011.

This study reports on a microfluidic system equipped with a sample pretreatment device and a nucleic acid amplification device for the rapid diagnosis of the human immunodeficiency virus‐1 (HIV‐1). The system analyzed proviral deoxyribonucleic acid (DNA) from an HIV‐infected Jurkat T cell line.  ........... More






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