Laboratory

ext 5288
 
Curriculum Vitae
 
Publications
 

Other

 

Nan-Haw Chow

E-mail:chownh@mail.ncku.edu.tw

TEL:06-2353535 ext 5288

FAX:06-2766195

 

Educations / Professional Experience

 

Educations
 

Institute of Pathology, College of Medicine, National Taiwan University, Taipei, M.S.

    China Medical College, Taichung, M.D.
   

 

Current Position   Professor and Chairperson, Department of Pathology, College of Medicine, National Cheng Kung University
     
 
 
Professional Experience 2001- Professor, Department of Pathology, Medical College,National Cheng Kung University

 

1997-1998 約翰霍普金斯大學, Brady 泌尿中心研究員

 

1996-2001 Associate professor, Department of Pathology, Medical College, National Cheng Kung University

 

1989-1996 Assistant professor, Department of Pathology, Medical College, National Cheng Kung University

 

1983-1986 Teaching assistant, Department of Pathology, Medical College, National Taiwan University

 

Expertise /Research Interests

 

Pathology, Tumor biology, Laboratory diagnosis
   
 

Research Interests

I. Genetic Model for Tumorigenesis of Human Bladder:

 The incidence of bladder cancer in southwest coast of Taiwan, where blackfoot disease is endemic, is unusually high. Epidemiological studies have established a strong link between arsenic exposure and bladder cancer; but the mechanisms underlying transformation of normal urothelium to cancer cells remains to be elucidated. Moreover, current treatment of patients with urinary tract cancer is still in preliminary stage, since not many clinicopathological indicators are effective in predicting clinical outcome. As a result, our laboratory has been trying to establish a progression model for bladder carcinogenesis (Figure 1). We have tested a number of oncogenes and tumor suppressor genes for their relevance in human bladder cancer (1-6, 8, 9). Currently, two inducible c-met and RON expression systems have been extensively studied in our laboratory, and increasingly molecular genetic techniques (1-3, 8) and functional genomic approaches have been integrated into our investigation. We hope that novel molecular mechanisms or biotargets of bladder cancer could be discovered in the future.

II. Cancer Prevention and Anti-angiogenesis in Human Diseases:

 Early diagnosis of urinary tract cancer remains the gold standard in improving clinical outome. It is well known that field cancerization is an important characteristic of transitional cell carcinoma and may affect the natural course of disease progression. As a result, it is imperative to modulate carcinogenesis as early as from the initiated cells in the field mucosa. This is the basic rationale for chemoprevention. Animal studies found that soybean feeding has a protective effect on bladder carcinogenesis in Swiss albino mice and on a transplantable murine tumor. We and other investigators have reported that genistein (5,7,49-trihydroxyisoflavone), daidzein (7,49-dihydroxyisoflavone), biochanin-A, and phytochemical concentrate tend to cause a dose-dependent inhibition of proliferation and induction of apoptosis on human cancer cells in vitro and in vivo (11). The molecular basis of anticancer effects of isoflavones is under intensive investigation (5, 10). We will also extend this line of research to other constituents of foods or other natural compounds, as well as in other cancer types and Graves’s disease.

     

 

Research direction Functional genomics of urothelial carcinoma, Anti-angiogenesis in Human Diseases
 

Honors & Awards