Laboratory

 
 
Curriculum Vitae
 
Publications
 

Other

 

Li-Wha Wu, Ph.D.

E-mail:liwhawu@mail.ncku.edu.tw

TEL:06-2353535 ext 3618(off.) ext 3620(lab.)

FAX:06-2095845

 

Educations / Professional Experience

 

Educations
1993

Ph.D. Genetics ,University of Minnesota, Twin Cities, MN, USA

 
1985

B.S. Food Science,National Chung Hsing University, Taichung, Taiwan

   

 

Current Position 2009~ Professor, Institute of Molecular Medicine, College of Medicine, National Cheng Kung University
 
 

Professional Experience

2012 - 2013

Visiting Scholar, Department of Pharmacology, School of Medicine, University of California, San Diego

2004 - 2009 

Associate Professor, Institute of Molecular Medicine, College of Medicine, National Cheng Kung University , Tainan, Taiwan             

 

2007/6

Visiting Scholar, Dr. Carlo Croce's Lab, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA .

 

1999 - 2004

Assistant Professor, Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan

 

1998 - 1999

Visiting Research Associate, Department of Microbiology and Immunology, Indiana University, Indianapolis, IN, U.S.A.

 

1996 - 1997

 Postdoctoral Fellow, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN, U.S.A.

 

1993 - 1996 

Postdoctoral Fellow , J. L. Pettis Memorial VAMC, Loma Linda, CA, U.S.A.

 

1989 - 1990

Teaching Assistant for Genetics, Department of Genetics and Cell Biology, University of Minnesota, Twin Cities, MN, U.S.A.

 

1987 - 1993

Research Assistant, Department of Genetics and Cell Biology, University of Minnesota, Twin Cities, MN, U.S.A.

 

1986 - 1993

Graduate Student, Department of Genetics and Cell Biology, University of Minnesota, Twin Cities, MN, U.S.A.

 

1985 - 1986

Research Associate, Panlabs, Inc., Taipei, Taiwan  

 

Expertise /Research Interests

 

Molecular biology, tumor biology, angiogenesis, oral carcinogenesis, and wound repair
   

 

 

Angiogenesis, formation of new blood vessels from existing endothelium, is essential for formation of mature vasculature and organogenesis during animal development, wound repair and female reproductive cycle in adults. This complex process involves basal lamina dissolution, migration, proliferation and differentiation of endothelial cells. Dysregulation of angiogenesis has been associated with various human pathologies including oral cancer and certain skin diseases. We focus on studying the molecular mechanism underlying these two diseases, and the altered activity of angiogenesis and other stromal components in the development of either disease. Our ultimate goal is facilitating the development of theranostic targets for oral cancer and inflammation related skin diseases.

My research interests are divided into 3 parts.

First: Understanding the underlying mechanism whereby angiogenesis is modulated at molecular levels. We are currently focusing on using RNA interference mini-library to screen for candidate genes involved in angiogenic modulation.

Second: Since oral cancer is the 5th leading cause of cancer death in Taiwan and the crosstalk between tumor cells and their stromal components in the same microenvironment plays a key role in cancer progression and metastasis, we will study molecular mechanism of oral carcinogenesis and the impact of the crosstalk between cancer and stromal cells in oral carcinogenesis using both clinical specimens and animal models.

Third: Since cancer is now known to be a never-healed wound, we will also use genetically engineered mice to study the role of our candidate genes in puncture-induced wound healing using both molecular and cellular approaches.

Current interests

 

(1)利用RNA干擾技術找尋調控血管新生有關之基因及其作用的分子機轉。藉由了解其分子機制,渴望協助新藥發展及對因血管新生失控的疾病作有效治療。

(2)口腔癌於近年來雖已躍居十大癌症死因第五位 雖然腫瘤的微環境在腫瘤生長與轉移扮演重要的角色其於口腔癌的仍不清楚。目前正利用動物模式及分子細胞生物等技術探討其於口腔上皮的癌化所扮演的角色;並進一步探討結合抗血管新生療法與現有的癌症治療在治療口腔癌可能性。

(3) 已知癌症被視為是無法癒合的傷口,因此利用基因轉殖或剔除鼠作皮膚疾病模式來探討該基因於皮膚傷口癒合角色的探討與藥物研發。

Honors & Awards

 
2017 榮獲醫學院教學優良教師
2009-2011 榮獲分醫所教學優良教師
2013-2018 榮獲分醫所教學優良教師
2015 榮獲鼓勵發表國際頂尖期刊獎勵
2003-12 Principle Investigator's Award by National Science Council
2009 成杏基金會優秀論文獎
2001 Research Award by National Science Council
1996-1997 Walther Oncology Center Postdoctoral Fellowship
1996-1997 Walther Oncology Center Postdoctoral Fellowship
1985 Bachelor of Science Degree with Honors, National Chung-Hsing University