孫孝芳 ( H. Sunny Sun, Ph.D.)
教授 (Professor)

E – Mail
   hssun@mail.ncku.edu.tw 
Office phone
886-6--2353535 ext: 3648
Lab phone
886-6--2353535 ext: 3645
FAX
886-6-209-5845
 

Personal information
Blood type : B
Birthday :
1964/4/30
Hobbies :
Educations
1. (1984/09~1986/05) Tunghai University, B.S.

2. (1989/10~1991/05) University of California-Davis, M.S

3. (1991/09~1996/02) University of Wisconsin-Madison, Ph.D.

Current Position
1.(1998/08~) Institute of Molecular Medicine, National Cheng Kung University Medical College
Professional Experience
1. (1998/02~1998/07) Department of Life Science, Chung Shan Medical University
Specialties
Gene Mapping, Molecular genetics, Comparative Genomics, Bioinformatics
Courses
Strategies to gene mapping in human diseases

Advanced Bioinformatics

Application of computer in biological studies

Bioinformatics

Research interesting

1. Mapping disease causing/susceptibility genes in human by using modern molecular genetics and advanced
bioinfomatics tools

2. Development of value-added databases, applications of bioinformatics

Research direction
1. Mapping gene for Neuro/Psychiatric diseases

2. Development and application of bioinformatics tools

3. Molecular mechanism of oncogenesis

4. Cancer gene mapping

5. Genomics Medicine

Research teams
Research assistant:5

Ph.D student:5

Master student:3

Undergraduate student:4

實驗室花絮
 
Publication List
A. Journal articles from the past five years

1. Tzeng, C. C, Tzeng, P. Y, Sun, H. S., Chen, R. M. and S. J. Lin. 2000 Implication of screening for FMR1 and FMR2 gene mutation in individuals with nonspecific mental retardation in Taiwan. Diagn. Mol. Pathol. 9: 75-80.

2. Lin, Y. M., Chen, C. W., Sun, H. S., Hsu, C. C., Chen, J. M., Lin, S.J., Lin, J. S. N. and P. L. Kuo. 2000. Y-chromosome microdeletion and its effect on reproductive decisions in Taiwanese patients presenting with nonobstructive azoospermia. Urology 56: 1041-1046.

3. Didion, B.A., Paszek, A. A., Rohrer, G. A., Sun, H. S. and C. K. Tuggle. 2000. Rapid communication: genetic linkage and physical mapping of a porcine sequence characterized amplified region (SCAR) to chromosome 6. J. Anim. Sci. 78: 3195-3196.

4. Yuan, K., Chang, C.-J., Hsu, P.-C., Sun, H. S., Tseng, C.-C., and J.-R. Wang. 2001. Detection of putative periodontal pathogens in non-insulin-dependent diabets mellitus and non-diabetes mellitus by polymerase chain reaction. J. Periodont Res. 36: 18-24.

5. Yu, T. -P., Sun, H.S., Wahls, S., Sanchez-Serrano, I. Rothschild, M.F. and C. K. Tuggle. 2001. Cloning of the full length pig PIT1 (POU1F1) cDNA and a novel alternative PIT1 transcript, and functional studies of their encoded proteins. Anim. Biotech. 12, 1-19.

6. Lin, Y. M., Chen, C. W., Sun, H. S., Tsai, S.J., Hsu, C. C., Teng, Y.N., Lin, J. S. N. and P. L. Kuo. 2001. Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic mem. Molecular Human Reproduction 7, 1015-1022.

7. Tsai SJ, Wu MH, Lin CC, Sun H.S, and Chen SM 2001 Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab 86: 5765-5773.

8. Sun, H. S., Anderson, T, -P, Yu, K, -S, Kim, L. L., Klindt, J. and C. K. Tuggle. 2002. Neonatal Meishan pigs show POU1F1 genotype effects on plasma GH and PRL concentration Anim. Reprod. Sci. 69:223-237.

9. Lin, Y. M., C. W. Chen, H. S. Sun, S. J. Tsai, J. S. N. Lin, P. L. Kuo. 2002. Presence of DAZL transcript and protein in mature human spermatozoa. Fertility and Sterility 77: 626-629.

10. Sun, H. S., Whallon, S., Ponce de Leon, F. A. and B. W. Kirkpatrick. 2002. Physical mapping of two bovine microsatellite loci. J. Anim. Sci. 80:868-869.

11. Sun, H. S*., C. K. Tuggle, A. Goureau, C. J. Fitzsimmons, P. Pinton, P. Chardon , M. Yerle. 2002. Precise mapping of breakpoints in conserved synteny between human chromosome 1 and pig chromosomes 4, 6 and 9. Anim. Genet. 33:91-96.

12. Sun, H. S., Chang, Y. T., Fann, C. S. J., Chang, C-J., Chen, Y. S., Hsu, Y-P., Yu, W. Y. and Cheng, A. T. A. 2002. Association Study of the Novel Human Serotonin 1B Receptor Gene Polymorphisms with Alcohol Dependence in Taiwanese Han. Biol Psychiatry 51: 896-901.

13. Lai, T. J., C. Y. Wu, C. S. J. Fann, F. M. Chang, and H. S. Sun*. 2002. Association study of the tryptophan hydroxylase gene polymorphism and bipolar affective disorder in Taiwan. Journal of Genetics and Molecular Biology 13:101-104.

14. Cheng, C. N., C.C. Lu, H. S. Sun, W. C. Su, J. S. Chen. 2002. Successful matched-unrelated bone marrow transplantation in a patient with beta-thalassemia major. J. Pediatric Hematology/Oncology 24: 579-581.

15. Chang,Y. T., H. S. Sun, C. S. J. Fann, C.-J. Chang, Z. H. Liao, J. L. Huang, E. W. Loh, W. Y. Yu, and A. T. A. Cheng. 2002. Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han. Molecular Psychiatry 7:828-829.

16. Wu MH, Sun HS, Lin CC, Pan HA, and Tsai SJ. 2003. Distinct mechanisms regulate cyclooxygenase-1 and -2 expression in peritoneal macrophages isolated from women with endometriosis. Mol Hum Reprod 8:1103-1110.

17. Sun, H. S*., I-J. Su, Y-C. Lin, J–S. Chen, and S-Y. Fang. 2003. A 2.6Mb interval on chromosome 6q25.2-q25.3 is commonly deleted in human nasal NK/T cell lymphoma. Brit J Haematology 122: 590-599.

18. Sun, H. S., Kuei-Yang Hsiao, Chih-Chao Hsu, Meng-Hsing Wu, and Shaw-Jenq Tsai. 2003. Transactivation of steroidogenic acute regulatory protein in human endometriotic stromal cells is mediated by the prostaglandin EP2 receptor. Endocrinology 144: 3934-3942.

19. Lin, Y.M.J., H.C. Yang, T.J. Lai, C.S.J. Fann, and H. S. Sun*. 2003. Receptor-mediated effect of serotonergic transmission in patients with bipolar affective disorder. J Med Genet 40:781-786.

20. Sun, H. S*., Hui-Chung Wang, Te-Jen Lai , Tso-Jen Wang, and Chih-Ming Li. 2004. Sequence variants and haplotype analysis of serotonin transporter gene and association with bipolar affective disorder in Taiwan. Pharmacogenetics 14:173-179.

21. Sun, H. S*., Hsu-Wen Tsai, Huei-Chen Ko, Fong-Ming Chang Tzung-Lieh Yeh. 2004. Association of the tryptophan hydroxylase gene polymorphism with depression, anxiety, and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women. Genes, Brain and Behavior 3: 328-336.

22. Sun, H. S., C. S. J. Fann, Hsien-Yuan Lane, Y-T Chang, C-J Chang, Y-L Liu, W-Y Yu, and A. T. A. Cheng. 2005. A functional polymorphism in the promoter region of the tryptophan hydroxylase (TPH1) gene is associated with alcohol dependence in one aboriginal group in Taiwan. Alcoholism - Clinical and Experimental Research 29 (1): 1-7.

23. Ya-Hui Chang, Wen-Hui Su1, Tso-Ching Lee, H. Sunny Sun, Chia-Hsiang Chen, Wen-Harn Pan, Shih-Feng Tsai and Yuh-Shan Jou. 2005. TPMD: a database and resources of microsatellite marker genotyped in Taiwanese populations. Nucleic Acids research 33: D174-D177.

24. T-J. Lai, C-Y. Wu, H-W. Tsai, Yi-Mei J Lin, H. S. Sun*. 2005. Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene and association with bipolar affective disorder in Taiwan. BMC Medical Genetics 6:14.

25. Ko-Fan Chen, Yen-Yu Lai, H. Sunny Sun and Shaw-Jenq Tsai. 2005. Transcriptional repression of human cad gene by hypoxia inducible factor-1 . Nucleic Acids Research 33(16):5190-5198.

26. Huang, S. Y., J. H. Lin, Y. H. Chen, C.K. Chuang, E.-C. Lin, M. C. Huang, H. S. Sun and W. C. Lee*. 2005. A reference map and identification of porcine testis proteins using two-dimensional gel electrophoresis and mass spectrometry. Proteomics 5:4205-4212.

27. Ying-Fan Chen, Po-Lin Kou, Shaw-Jenq Tsai, Ko-Fan Chen, Hsiang–Han Chan, Chung Ming Chen, and H. Sunny Sun. 2006. Computational analysis and refinement of sequence structure on chromosome 22q11.2 region: application to the development of quantitative real-time PCR assay for clinical diagnosis. Genomics 87:290-297.

28. Yung-Hsian Hsu, Chaio-Wei Chen, H. Sunny Sun, Ruwen Jou, Jen-Jyh Lee and Ih-Jen Su. 2006. Association of NRAMP 1 Gene Polymorphisms with Susceptibility to Tuberculosis in Taiwanese Aboriginals. JFMA 105: 363-369.

29. Yen-Ni Teng, Yung-Ming Lin, H. Sunny Sun, Pei-Yang Hsu,Chia-Ling Chung, Pao-Lin Kuo, M.D. 2006. Association of DAZL Haplotypes with Spermatogenic Failure in Infertile Men. Fertility and Sterility 86:129-35.

30. Shiang Ning Leaw, Hsien Chang Chang, Hsiao Fang Sun, Richard Barton, Jean-Philippe Bouchara, Tsung Chain Chang. 2006. Identification of Medically Important Yeasts by Sequence Analysis of the Internal Transcribed Spacer Regions. Journal of Clinical Microbiology 44: 693–699.

31. Chen, C.H., Lin, E.C., Cheng, W.T.K., Sun, H.S., Mersmann, H.J., Ding, S. T. 2006. The abundantly expressed genes in pig adipose tissue: an expressed sequence tag approach. J. Animal Science 84:2673-83.

32. Chen, Tsung-Ming, Pao-Lin Kuo, Chien-Hui Hsu, Shaw-Jenq Tsai, Mong-Jen Chen, Chieh-Wei Lin and H. Sunny Sun. 2006. Functional microsatellite in the 3’ untranslated region of human fibroblast growth factor 9 gene is associated with male-to-female sex reversal. Human Mutation (In Press).

33. Chuang, Pei-Chin, H. Sunny Sun, Tsung-Ming Chen, and Shaw-Jenq Tsai. 2006. Prostaglandin E2 induces fibroblast growth factor-9 via EP3 mediated protein kinase C-delta and Elk-1 dependent transcriptional activation. MCB (In Press).

34. Chan, Hsiang-Han, Shaw-Jenq Tsai, H. Sunny Sun. 2007. TAG: a comprehensive database for cancer research. Nucleic Acids Research 2007 Molecular databases collections (In Press).

35. Lin, Yi-Mei, Shin-Chih Chao; Te-Jen Lai; Tsung-Ming Chen; Jia-Shing Chen and H. Sunny Sun. 2006. Functional polymorphisms of the human tryptophan hydroxylase 2 genes confer risk of bipolar disorder. ARCHIVES OF GENERAL PSYCHIATRY (In revision).

36. Shin-Chih Chao, Cheng-Hsien Tsai, Yuh-Jyh Lin, Chyi-Her Lin, Louise Chuang, Jing-Ming Wu, Shio-Jean Lin, and H. Sunny Sun. 2005. Modeling the mutational effects on calcium binding to the epidermal growth factor (EGF) domain of fibrillin-1: correlation of genotype and heterogeneous clinical phenotypes. Pediatric and Developmental Pathology (In revision).

37.Chen, Tsung-Ming, Pao-Lin Kuo, Chien-Hui Hsu, Shaw-Jenq Tsai, Mong-Jen Chen, Chieh-Wei Lin and H. Sunny Sun*. 2007. Microsatellite in the 3’ untranslated region of human fibroblast growth factor 9 (FGF9) gene exhibits pleiotropic effect on modulating FGF9 protein expression. Human Mutation 28:98. (Impact Factor7.033)

38.     Lin, Yi-Mei J., Fabian Davamani, Wei-Chih Yang, Te-Jen Lai, and H. Sunny Sun*. 2008. Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese. Behavioral and Brain Functions 4:21. (Impact Factor2.3)

39.      Lin, Yi-Mei J., Huei-Chen Ko, Fong-Ming Chang, Tzung-Lieh Yeh, and H. Sunny Sun*. 2009. Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. Archives of Women's Mental Health 12(6):401-8. (Impact Factor2.208)

40.Shin-Chih Chao, Jia–Shing Chen , Cheng-Hsien Tsai, Joy Yi-Mei Lin, Yuh-Jyh Lin, and H. Sunny Sun*. 2010. Novel exon nucleotide substitution at the splice junction causes a neonatal Marfan syndrome. Clinical Genetics 77:453-563. (Impact Factor:3.206)

B. Conference abstract

1. Chen, T. -M., Lai, D. T. and H. S. Sun. 2000. The association of tryptophan hydroxylase gene polymorphism with bipolar affective disorder. Eighth symposium on recent advances in cellular and molecular biology: p97.

2. Kuo, Y. -C., Lai, D. T. and H. S. Sun. 2000. Association analysis of serotonin transporter gene polymorphisms with bipolar affective disorder in Taiwan. Eighth symposium on recent advances in cellular and molecular biology: p97.

3. Tzeng, P. –Y., Tzeng, C. –C., Sun, H. S. and S. –J. Lin. 2000. Implication of screening for FMR1 and FMR2 gene mutation in individuals with nonspecific mental retardation in Taiwan. Eighth symposium on recent advances in cellular and molecular biology: p94.

4. Chen, C. –W., Lin, Y. –M., Sun, H. S. and S. –J. Lin. 2000. Y chromosome microdeletions and spermatogenesis defect. Eighth symposium on recent advances in cellular and molecular biology: p92.

5. Yung , W.-Z., Lai , D.T. and H.S. Sun. 2000. The association study of monoamine oxidase A polymorphism with bipolar affective disorder in Taiwan. The Fifteenth Joint Annual Conference of Biomedical Sciences: p247.

6. Chen, C. -C., Lai, D.T. and H.S. Sun. 2000. A dopamine transporter gene marker for bipolar affective disorder. The Fifteenth Joint Annual Conference of Biomedical Sciences: p247.

7. Sun, H. S., Tuggle, C. K., Goureau, A., Fitzsimmons, C. J., Chardon , P. and M. Yerle. 2000. Precise mapping of breakpoints in conserved synteny between human chromosome 1 and pig chromosomes 4, 6 and 9. XXVII International Conference on Animal Genetics: p18.

8. Sun, H. S. 2000. Association study of the tryptophan hydroxylase gene and bipolar affective disorder in Taiwan. Conference on Genetic Epidemiology in Taiwan: p23.

9. Wu, C. Y., Lai, T. J., Chang, F. M., and H. S. Sun. 2001. Characterization of single-nucleotide polymorphisms in coding region of the human tryptophan hydroxylase gene. Ninth symposium on recent advances in cellular and molecular biology: p40.

10. Lin, Y-M. J. and H. S. Sun. 2001. Establish a rapid genotyping system for single-nucleotide polymorphisms (SNPs) by using multiplex oligonucleotide chain reaction and allele-specific oligonucleotide assay. Ninth symposium on recent advances in cellular and molecular biology: p95.

11. Chen, C. W., Lin, Y. M., Sun, H. S., S. J. Tsai, and P.L. Kuo. 2001. Expression of DAZLA gene in the testes of azoospermic men- immunohistochemical study and quantitative competitive reverse transcription polymerase chain reaction. Ninth symposium on recent advances in cellular and molecular biology: p63.

12. Wu, C. Y., Lai, T. J., Chang, F. M., and H. S. Sun. 2001. A simple and rapid method for identification of the single-nucleotide polymorphisms. The Sixteenth Joint Annual Conference of Biomedical Sciences: p93.

13. Sun, H. S. and S. J. Tsai. 2001. Establish a web-based integrated single-nucleotide polymorphism query/detection system. Medical Informatics Symposium/Show in Taiwan 2001: pp96-99.

14. Sun, H. S., C.-Y. Wu, C. S. J. Fann, T.-M Chen and T.-J. Lai. 2001. Association study of the tryptophan hydroxylase gene and bipolar affective disorder in Taiwan. Am. J. Hum. Genet. 69 (Supplement): 404.

15. Lin, Y.-C., S.-Y. Fang, I.-J. Su and H. S. Sun. 2002. Molecular genetic analyses of EBV-associated T/NK cell lymphoma in Taiwan. Tenth symposium on recent advances in cellular and molecular biology A34: p57.

16. Tsai, H.-W., H.-C. Ko, F.-M. Chang, T.-L. Yeh and H. S. Sun. 2002. Molecular Genetic Study of the Tryptophan Hydroxylase gene in Depression and Anxiety. Tenth symposium on recent advances in cellular and molecular biology A89: p88.

17. Wang, H.C., T. L., Lai, and H. S. Sun. 2002. Association analysis of single-nucloetide polymorphism around SLC6A4 gene and bipolar affective disorder in Taiwan. The Seventeenth Joint Annual Conference of Biomedical Sciences: p136.

18. Lin, Y.M.J., T. L. Lai, C.S.J. Fann and H. S. Sun. 2002. Association study of serotonin receptor genes and bipolar affective disorder (BPD) in Taiwan. The Seventeenth Joint Annual Conference of Biomedical Sciences: p134.

19. Jia–Shing Chen, Ih-Jen Su, Sheen-Yie Fang, H. Sunny Sun. 2002. Quantitative PCR of Sequence Tagged Sites Analysis of EBV-Associated T/NK cell lymphoma in Taiwan. Proram and Abstract book of the 4th NHRI Conference on Nasopharyngeal Carcinoma and Herpesvirus-Associated Diseases. May 18-19, 2002. Venue: Aspire Learning Complex, Tao-Yuan, Taiwan.

20. Lin, Y.J., T. J. Lai., H.S. Sun. 2002. Genetic analysis of serotonin system in pathogenesis of bipolar affected disorder. HGM2002 Program and Abstract book: p195.

21. H. S. Sun, H-C. Wang, and T-J. Lai. 2002. Association analysis of single-nucleotide polymorphisms of serotonin transporter gene and bipolar affective disorder in Taiwan. Am. J. Hum. Genet. 71 (Supplement): 353.

22. H. Sunny Sun. 2002. Molecular genetic analysis of EBV-associated nasal NK/T cell lymphoma in Taiwan. Program and Abstract book of the Advanced Studies Institute Conference: The Genome-Phenome Link. October 21-25, 2002. Venue: University House, The Australian National University, Canberra, Australia.

23. H. Sunny Sun, Y-C. Lin, J-S. Chen, S.Y. Fang, I. J. Su. 2003. Identification of putative tumor suppressor gene for EBV-associated NK/T cell lymphoma in Taiwan. The 8th Asian Research Symposium in Rhinology. March 15-16, 2003. Tainan, Taiwan.

24. C.M. Chen, M.J. Chen, and H. Sunny Sun. 2003.Functional analysis of the polymorphic microsatellite motifs of the human fibroblast growth factor 9 gene. The Eighteenth Joint Annual Conference of Biomedical Sciences O58: p74.

25. Ying-Fan Chen, Ko-Fan Chen, Hsiang-Han Chan, Shaw-Jenq Tsai, H.Sunny Sun 2003.Genome-wide Search of Low-copy-repeats and its Application in Molecular Medicine. Bioinformatics in Taiwan Program Handbook:p89.

26. Hsiang-Han Chan, Shaw-Jenq Tsai, H.Sunny Sun. 2003.An Oncogenes/Tumor Suppressor Genes Value-added Database for Bio-arch. Bioinformatics in Taiwan Program Handbook:p92H.

27. Sunny Sun, Tzyy-Pyng Her, Shaw-Jenq Tsai. 2003.Establish a Single Nucleotide Polymorphism (SNP) Value-added Database.Bioinformatics in Taiwan Program Handbook:p93.

28. Ko-Fan Chen, Hsiang-Han Chan, H.Sunny Sun, Shaw-Jenq Tsai. 2003. Whole Genome Search of Candidate Hypoxia Response Genes By Hidden Markov Model Profile. Bioinformatics in Taiwan Program Handbook:p96

29. H.S.Sun, S-M.Lin, J.-S. Chen. 2003.Oncogenic pathway of nasal NK/T cell lymphoma with novel germ line missense mutation in the /GF2R gene. Am. J. Hum. Genet. 73 (Supplement):248.

30. C.M. Chen, P-L. Kuo, S. J. Tsai, M. R. Chen, J. W. Lin, and H. Sunny Sun. 2004. Sequence variation of the fibroblast growth factor 9 gene in patients with male-to-female sex reversal. Twelfth symposium on recent advances in cellular and molecular biology A103: p163.

31. Jia–Shing Chen, Ih-Jen Su, Sheen-Yie Fang, H. Sunny Sun. 2004. Characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2): the potential role on tumorigenesis of EBV-associated nasal NK/T cell lymphoma.. Program and Abstract book of the 5th NHRI Conference on Tumor-associated herpesviruses: P43. June 5-6, 2004. Venue: Aspire Learning Complex, Tao-Yuan, Taiwan.

32. Ying-Fan Chen, Po-Lin Kou, Shaw-Jenq Tsai, Ko-Fan Chen, Hsiang–Han Chan, Chung Ming Chen, and H. Sunny Sun. 2004. Genome-Wide Scan for Low Copy Repeats: Application in Clinical Detection of Low-Copy-Repeat -Mediated Genomic Disorders. Am. J. Hum. Genet. 74 (Supplement):248.

33. Shin-Chin Chao, Pao-Lin Kuo, H. Sunny Sun. 2005. Genetic analysis of the tryptophen hydroxylase 2 (TPH2) gene in Taiwan. Thirteenth symposium on recent advances in cellular and molecular biology : p143.

34. Chien-Hui Hsu, Tsung-Ming Chen, H Sunny Sun. 2005. The post-transcriptional regulation of human FGF9 3’untranslated region (3’UTR) on FGF9 protein expression. Thirteenth symposium on recent advances in cellular and molecular biology : p144.

35. Ya-Chi Lin, Ih-Jen Su, H. Sunny Sun. 2005. Characterization of a theoretical protein C6orf35 on chromosome 6q25.3. HGM 2005 Human Genome Meeting Program and Abstract book: p79. Kyoto, Japan 18th-21st April 2005.

36. H. Sunny Sun. 2005. Genome-wide scan for low copy repeats: application in clinical detection of LCR-mediated genomic disorders. Australia-Taiwan Bioinformatics Symposium 2005. Program book. Hsinchu, Taiwan 6th-7th September 2005.

37. Ying-Fan Chen, Po-Lin Kou, Shaw-Jenq Tsai, Ko-Fan Chen, Hsiang-Han Chan, Chung-Ming Chen, H.Sunny Sun. 2005. Refinement of sequence structure on chromosome 22q11.2 region: Application to the development of quantitative real-time PCR assay for clinical diagnosis. Bioinformatics in Taiwan 2005 Program Handbook:p77.

38. Hsiang-Han Chan, Shaw-Jenq Tsai, H.Sunny Sun. 2005. Establish tumor-associated gene (TAG) database for bio-medical research. Bioinformatics in Taiwan 2005 Program Handbook:p76.

39. Kuei-Yang Hsiao, Ko-Fan Chen, H. Sunny Sun, Chun-Liang Cheng, Shaw-Jenq Tsai. 2005. The BEST: A web-based plateform for identifying targeted genes of a transcription factor. Bioinformatics in Taiwan 2005 Program Handbook:p73.

40. Ko-Fan Chen, Hsiang-Han Chan, H. Sunny Sun, Yen-Yu Lai, Shaw-Jenq Tsai. 2005. Genome-wide identification of Hypoxia Inducible factor regulated genes. Bioinformatics in Taiwan 2005 Program Handbook:p74.

41. H. Sunny Sun, YMJ Lin, SC Chao, TJ Lai , and TM Chen. 2005. Association of functional polymorphisms in neuronal tryptophan hydroxylase gene with bipolar affective disorder. Am. J. Hum. Genet. 74 (Supplement).

42. Wen-Chi Hsiao, Ih-Jen Su, H. Sunny Sun. 2006. Genomic alteration in EBV-infected or Ebv-oncoprotein LMP1-transfected lymphoma cells. The 21th Joint Annual Conference of Biomedical Sciences 2006 Program Handbook:p188.

43. Hsiang-Han Chan, Shaw-Jenq Tsai, H. Sunny Sun. 2006. Development of tumor-associated gene (TAG) database for biomedical research. The 21th Joint Annual Conference of Biomedical Sciences 2006 Program Handbook:p69.

44. Chun-Ming Chan, Shaw-Jenq Tsai, Ko-Fan Chen, Hsiang-Han Chan, H. Sunny Sun. 2006. Identification of genomic regions that are potentially involved in low-copy repeat mediated chromosome deletion/dupliction. The Fourth Asia Pacific Bioinformatics Conference 2006 Program Handbook:p9.

45. H. Sunny Sun, Chung-Ming Chen , Chia-Yen Wu, Wen-Chuan Lee, En-Chung Lin, Mu-Chiou Huang, and San-Yuan Huang. 2006. High-resolution physical mapping of 25 EST from porcine testis by radiation hybrid panel. HUGO-AP 2006 Program and Abstract Book : p81.

46. S.Y. Huang W.C. Lee, J.H. Lin, C.-K. Chuang, E.-C. Lin, M.C. Huang, and H. Sunny Sun. 2006. Differential protein expression during postnatal development of porcine testis. HUGO-AP 2006 Program and Abstract Book : p81.

C.專書及專書研討會論文

1. Sun, H. S. 2000. From Mighty mouse to Schwarzenegger cattle—study and application of comparative genomics. 2000. Feed Manufacturing Technology Short Course Proceedings: p36-42.

D.技術報告及其它
研究計畫

1. 血清素傳遞系統基因與躁鬱症之遺傳關連性研究 (8908~9007)

2. 台灣地區躁鬱症之分子遺傳研究 (9008~9107)

3. 成立南區生物資訊教育訓練課程推廣服務中心 (8908~9112)

4. 台灣地區EB 病毒相關之T/NK淋巴癌的細胞遺傳及分子遺傳研究(8908~9007)

5. 建立網路介面整合式單核甘酸多型性(SNP)查詢系統及快速發展SNP的生物方法
(8908~9107)

6. 發展快速鑑定單核甘酸多型性之方法及建立加值型單核甘酸多型性資料庫 (9008~9207)

7. 建立遺傳多型性分析核心實驗室 (9011~9212)

8. 豬繁殖力功能性基因組解析及生物晶片之研發與應用--利用螢光原位雜交及輻射雜合定位技術
建立豬繁殖性狀表現系列標示(EST)的高解析圖譜 (9101~9312)

9. 應用醫學基因體資訊核心 (9105~9704)

10. 台灣地區EB病毒相關之NK/T淋巴癌的抑癌基因定位研究 (9105~9404)

11. EB病毒感染在引發宿主基因體改變及癌症易感性之影響 (9405~9704)