Curriculum Vitae
 
Publications
 

Other

 

 

橋本昌征 專案助理教授 (Masayuki Hashimoto)

E-mail:hashmate@mail.ncku.edu.tw

TEL:06-2353535 ext 3592

FAX:06-2095845

 

Educations / Employment Experience

 

Educations 2000/ 03 Ph. D. (Dr. of Agriculture) from Graduate School of Science and Technology, Niigata University (Niigata, Japan).
  1996/ 03 Master's degree from Graduate School of Agriculture, Niigata University (Niigata, Japan).
  1994/ 03 Graduated from Department of Agricultural Chemistry, Niigata University (Niigata, Japan).
   

 

Employment history

2013/ 05 - now

Project Assistant Professor, Institute of Molecular Medicine, National ChengKung University Medical College, Tainan, Taiwan

 

2007/ 11 - 2013/ 04

Assistant Professor, Young Researchers Empowerment Center, Shinshu Uni

 

2005/ 06 - 2007/ 10

Assistant Professor, Division of Gene Research Center, Human and Environment Science Research Center, Shinshu University.

 

2002/ 08 - 2005/ 05

Postdoctoral research fellow of Department of Biology, Tokyo Metropolitan University.

 

2002/ 04 - 2002/ 07

Postdoctoral research fellow of Kyowa Hakko Co., Ltd., detached to Department of Biology, Tokyo Metropolitan University.

 

2000/ 04 - 2002/ 03

Postdoctoral research fellow of Bio-oriented Technology Research Advancement Institution, detached to Department of Agricultural Chemistry, Shizuoka University.

 

Research goal

 

I plan to design and build a bacterial genome eventually. This is also a big goal for synthetic biology. But the benefits of the achievement will be incredible. It will enable to create specific bacteria to solve various problems in health, energy, materials, food and so on. For the aim, understand whole life mechanism in a cell is necessary. A well studied and simple organism will take us to the goal faster. Therefore, I have studied bacterial physiology and genomic engineering in some model bacteria.

   

Current interests

 

1) We develop a in vivo cloning method for long fragment which is too long for PCR amplification. We demonstrated to clone 40 and 80 kb fragment from gram negative bacteria. Then, we are going to expand the method in variety of bacteria and further long fragment.

2) We found that restriction-modification enzymes are involved in genomic evolution in uropathogenic E. coli. In addition, we identified several novel restriction enzymes. Then, we are going to characterize the novel enzymes and investigating the association between the gene and genomic evolution in pathogenic E. coli.

3) In some pathogenic bacteria like E. coli o157, the expression of toxin is triggered by prophage induction. Then, we are screening an inhibitor for the prophage induction to repress the toxin expression.