實驗室

分機3615
 
個人資料
 
研究成果
 

其他

 

張玲教授(Christina Ling Chang)

E-mail:clchang@mail.ncku.edu.tw

電話:06-2353535 分機3615

傳真:06-2095845

 

學經歷

 

學歷 1990-1992 Postdoctoral Fellow, Cancer Genetics & Biology, University of Michigan, USA
  1987-1990 Postdoctoral Researcher, Enzymology, Kansas State University, USA
  1983-1987 Ph.D. Biochemistry, Kansas State University, USA
  1978-1979 M. S. Dietetic Management, Kansas State University, USA
  1969-1973 B. S. Nutrition, Fu-Jen University, Taiwan
   

 

現職 國立成功大學醫學院分子醫學研究所專任教授
 
 
  2007-2010 Director, Institute of Molecular Medicine, National Cheng Kung University, Tainan, Taiwan, ROC

經歷

2003-2005 Research Associate Professor, Department of Medicine/Cancer Center, University of California, San Diego, USA

 

1997-2003 Research Assistant Professor, Department of Medicine/Cancer Center, University of California, San Diego, USA

 

1992-1995 Research Assistant Professor, Department of Pediatrics, University of Michigan, USA

 

1980-1984 Registered Dietitian, American Dietetic Association

 

1980-1981 Instructor, Department of Dietetic, Restaurant, and Institutional Management, Kansas State University, USA

 

1980 Assistant Dietitian, St. Mary Hospital, Manhattan, Kansas, USA

 

1975-1978 Manager, Food and Dormitory Services, Asian Vegetable Research and Development Center, Taiwan

 

1973-1974 Instructor, Chung-Hwa Junior College of Medical Technology, Taiwan

 

專長/研究興趣

 

腫瘤轉移 、DNA傷害和修護

   

 

興趣:

 癌症發生與惡化 (cancer development and progression) 包含基因上的微衛星體不穩定 (microsatellite instability, MSI)。在癌症病人中,腫瘤移轉(tumor metastasis)是死亡的主要原因。 為了降低癌症發生率與死亡率,本實驗室以大腸癌(colorectal cancer)與兒童神經母細胞瘤(neuroblastoma)為癌症模型,從事下列兩大方向的研究。

  方向:

1. 癌症預防 (cancer prevention): 探討發炎或化療如何導致大腸癌細胞與斑馬腸中的MSI,並篩選藥物以預防發炎或化療所導致的MSI。

2. 腫瘤轉移的分子機制: NDP kinase A/NM23-H1如何調控兒童神經母細胞瘤的轉移與神經的分化?

 

榮譽獎項

 
2009 國立成功大學醫學院教學成果(英文、醫學與生活)團體組第二名
2008 國立成功大學97年度教學優良教師
2007-present National Cheng Kung University Landmark Grant – Functional Genomic Approach for Discovery of Molecular Mechanisms and Therapeutic Targets (DMMaTT) of Human Cancer
2007-present Taiwan National Health Research Institute – Cancer prevention: targeting genetic and epigenetic events
2005-present Taiwan National Science Council (NSC) Grant – Molecular mechanism of NDP kinase A in tumor metastasis
2000-2005 United States National Institute of Health (NIH) RO1 Grant – Molecular mechanism of NDP kinase A in tumor metastasis
2001-2005 United States NIH Supplemental Grant – Mammalian Cancer Models
2001 United States NIH Equipment supplemental grant
1999-2001 California Cancer Research Program Grant – Pilot study for molecular mechanism of NDP kinase A in tumor metastasis
1992-1995 Special Fellowship, Leukemia Society of America
1990-1991 Postdoctoral Fellowship, Developmental Biology Training Grant, University of Michigan, USA
1982-1983 nternational Fellowship, Omicron Nu Honor Society, USA
1970-1971 Honor Student Award, Fu-Jen University, Taiwan